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AB117960

Anti-Butyrylcholinesterase antibody [OTI4C12]

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(1 출판물)

Mouse Monoclonal Butyrylcholinesterase antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human BCHE.

대체 명칭 보기

CHE1, BCHE, Cholinesterase, Acylcholine acylhydrolase, Butyrylcholine esterase, Choline esterase II, Pseudocholinesterase

1 이미지
Western blot - Anti-Butyrylcholinesterase antibody [OTI4C12] (AB117960)
  • WB

Unknown

Western blot - Anti-Butyrylcholinesterase antibody [OTI4C12] (AB117960)

All lanes:

Western blot - Anti-Butyrylcholinesterase antibody [OTI4C12] (ab117960) at 1/2000 dilution

Lane 1:

HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) cell lysate transfected with pCMV6-ENTRY control at 5 µg

Lane 2:

HEK-293T cell lysate transfected with pCMV6-ENTRY Butyrylcholinesterase cDNA at 5 µg

Predicted band size: 21 kDa,68 kDa

false

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI4C12

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human BCHE.

P06276

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대체품

Primary Antibodies

AB154763

Anti-Butyrylcholinesterase antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Butyrylcholinesterase antibody (AB154763)

  • 0
  • 0
Primary Antibodies

AB17246

Anti-Butyrylcholinesterase antibody [3E8]

ELISA - Anti-Butyrylcholinesterase antibody [3E8] (AB17246)

  • 0
  • 0
Primary Antibodies

AB236577

Anti-Butyrylcholinesterase antibody

Immunocytochemistry/ Immunofluorescence - Anti-Butyrylcholinesterase antibody (AB236577)

  • 0
  • 0
Primary Antibodies

AB151554

Anti-Butyrylcholinesterase antibody [EPR3033(2)]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-Butyrylcholinesterase antibody [EPR3033(2)] (AB151554)

  • 0
  • 0

보완 제품

Assay Kits

AB322429

Human Butyrylcholinesterase ELISA Kit- Extracellular

Recombinant|SimpleStep

Sandwich ELISA - Human Butyrylcholinesterase ELISA Kit- Extracellular (AB322429)

  • 0
  • 0
Primary Antibodies

AB31276

Anti-Acetylcholinesterase antibody

Flow Cytometry - Anti-Acetylcholinesterase antibody (AB31276)

  • 4
  • 4
Primary Antibodies

AB32127

Anti-Synaptophysin antibody [YE269] - Synaptic Marker

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Western blot - Anti-Synaptophysin antibody [YE269] - Synaptic Marker (AB32127)

  • 5
  • 39
Primary Antibodies

AB170905

Anti-Tyrosinase antibody [EPR10141]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Tyrosinase antibody [EPR10141] (AB170905)

  • 5
  • 2
Assay Kits

AB283363

Acetylcholinesterase Inhibitor Screening Kit (Colorimetric)

Functional Studies - Acetylcholinesterase Inhibitor Screening Kit (Colorimetric) (AB283363)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>" } } }
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제품 세부 정보

Clone OTI4C12 (formerly 4C12).
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
Purification 관련 사항
Purified from cell culture supernatant by affinity chromatography.
보관 버퍼
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Butyrylcholinesterase often called BuChE or BChE is a serine hydrolase enzyme that catalyzes the hydrolysis of ester compounds such as butyrylcholine. It has a molecular mass of approximately 85 kDa. BChE is structurally similar to acetylcholinesterase (AChE) and is found in various tissues with high expression in the liver plasma and the central nervous system. This enzyme acts as a scavenger by breaking down circulating choline esters and certain therapeutic drugs playing an important role in detoxifying the blood.
Biological function summary

This enzyme is significant in nervous system function and is not restricted to acetylcholine breakdown but can hydrolyze larger ester molecules. It forms part of a complex regulatory mechanism alongside acetylcholinesterase ensuring precise modulating of neurotransmitter signaling. BChE can also serve as a backup to acetylcholinesterase in breaking down neurotransmitters therefore contributing to maintaining synaptic balance and functionality.

Pathways

BuChE is involved in the cholinergic signaling pathway playing a significant role in neurotransmitter regulation. This pathway is important for muscle activation and memory processing. BChE also impacts the metabolism of certain ester-type drugs used in anesthesia. Its activity balances with acetylcholinesterase modulating the availability of acetylcholine within synaptic clefts and seamlessly integrating into broader physiological processes.

Altered BChE activity correlates with Alzheimer's disease and certain liver diseases. In Alzheimer's decreased BChE activity parallels reduced acetylcholinesterase function which affects cholinergic transmission in the brain contributing to memory deficits. Disorders like liver cirrhosis also show a compromised BChE level due to liver's impaired enzyme production aligning it closely with liver function and disease diagnostics.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
See full target information BCHE
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Scientific reports 10:7863 PubMed32398763

2020

Equine penile squamous cell carcinoma: expression of biomarker proteins and EcPV2.

Applications

Unspecified application

Species

Unspecified reactive species

Callum Arthurs,Alejandro Suarez-Bonnet,Claire Willis,Boyu Xie,Natalie Machulla,Tim S Mair,Kevin Cao,Michael Millar,Christopher Thrasivoulou,Simon L Priestnall,Aamir Ahmed
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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