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AB220962

Anti-C11orf84 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal C11orf84 antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human SPINDOC aa 200-350.

대체 명칭 보기

C11orf84, SPINDOC, Spindlin interactor and repressor of chromatin-binding protein, SPIN1-docking protein, SPIN-DOC

2 이미지
Immunocytochemistry/ Immunofluorescence - Anti-C11orf84 antibody (AB220962)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-C11orf84 antibody (AB220962)

Immunofluorescent analysis of PFA-fixed, Triton X-100 permeabilized A431 cells labeling C11orf84 with ab220962 at 4 μg/ml. Antibody staining is shown in green.

Western blot - Anti-C11orf84 antibody (AB220962)
  • WB

Supplier Data

Western blot - Anti-C11orf84 antibody (AB220962)

All lanes:

Western blot - Anti-C11orf84 antibody (ab220962) at 1/100 dilution

All lanes:

RT4 cell line

Predicted band size: 41 kDa

true

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human SPINDOC aa 200-350. The exact immunogen used to generate this antibody is proprietary information.

Q9BUA3

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보완 제품

Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB220914

Anti-COQ2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-COQ2 antibody (AB220914)

  • 0
  • 0
Secondary Antibodies

AB191866

VHH Single Domain Anti-Rabbit IgG Fc (HRP)

Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - VHH Single Domain Anti-Rabbit IgG Fc (HRP) (AB191866)

  • 5
  • 2
Primary Antibodies

AB137383

Anti-Carma 3 antibody

Western blot - Anti-Carma 3 antibody (AB137383)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

C11orf84 also known as chromosome 11 open reading frame 84 is a lesser-known protein consisting of 242 amino acids with a predicted mass of approximately 27 kDa. Present in many tissues C11orf84 shows higher expression in the brain indicating a potential role linked to neurological processes. The understanding of this protein's exact mechanical functions is limited but its conservation across species suggests significance in cellular actions.
Biological function summary

C11orf84 interacts within cellular systems and possibly takes part in developing cellular structure and signaling. Reports suggest that it may act within multi-protein complexes but precise details on its complex associations are currently understudied. The presence of C11orf84 is consistent with proteins involved in maintaining cellular organization and perhaps signal transduction pointing to a wider involvement in cell biology.

Pathways

Established connections hint that C11orf84 may have a role in neurological pathways such as neural development or synaptic modulation. While direct association within these pathways requires further research C11orf84's expression in the brain links it to proteins like NLGN1 and SHANK3 known for their roles in neural signaling pathways. These connections suggest that C11orf84 might engage in modulating synaptic adherence and signaling efficiency.

Investigations into C11orf84 suggest potential links to neurological conditions such as autism spectrum disorders and schizophrenia. The commonness of the protein within the brain ties it to neuropsychiatric conditions where dysregulation impacts brain function. Its relation to other proteins like NRG1 which play roles in cognitive disorders provides a starting point for understanding how C11orf84 might contribute to these conditions. Further studies are necessary to clarify the role of C11orf84 in disease pathogenesis and if it represents a potential therapeutic target.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Chromatin protein that stabilizes SPIN1 and enhances its association with histone H3 trimethylated at both 'Lys-4' and 'Lys-9' (H3K4me3K9me3) (PubMed : 33574238). Positively regulates poly-ADP-ribosylation in response to DNA damage; acts by facilitating PARP1 ADP-ribosyltransferase activity (PubMed : 34737271).
See full target information SPINDOC
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The Journal of biological chemistry 300:107783 PubMed39303913

2024

Downregulation of the mA reader YTHDC2 upregulates exosome content in lung adenocarcinoma via inhibiting IFIT and OAS family members.

Applications

Unspecified application

Species

Unspecified reactive species

Zhixin Yin,Lifang Ma,Xiaoting Tian,Qi Sun,Congcong Zhang,Yikun Wang,Yayou Miao,Xiangfei Xue,Yongjie Wang,Jiayi Wang,Xiao Zhang,Xumin Hou

OncoTargets and therapy 15:555-570 PubMed35611367

2022

is Highly Expressed in Pan-Cancer Samples and Can Promote the Proliferation, Invasion and Migration of Hepatocellular Carcinoma Cells by Activating Wnt/β-Catenin Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Wangxia Tong,Lilan Yang,Li Liu,Xudong Liu,Ning Luo
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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