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AB235343

Anti-C16orf48 antibody

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Rabbit Polyclonal C16orf48 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human ENKD1.

대체 명칭 보기

C16orf48, UNQ6410/PRO21183, ENKD1, Enkurin domain-containing protein 1

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C16orf48 antibody (AB235343)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C16orf48 antibody (AB235343)

Paraffin-embedded human placenta tissue stained for C16orf48 with ab235343 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C16orf48 antibody (AB235343)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C16orf48 antibody (AB235343)

Paraffin-embedded human testis tissue stained for C16orf48 with ab235343 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human ENKD1.

Q9H0I2

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대체품

Primary Antibodies

AB224560

Anti-C16orf48 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C16orf48 antibody (AB224560)

  • 0
  • 0
Primary Antibodies

AB224561

Anti-C16orf48 antibody

Immunocytochemistry/ Immunofluorescence - Anti-C16orf48 antibody (AB224561)

  • 0
  • 0

보완 제품

Primary Antibodies

AB92516

Anti-Calreticulin antibody [EPR3924] - ER Marker

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant|KO Validated|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Calreticulin antibody [EPR3924] - ER Marker (AB92516)

  • 4
  • 6
Primary Antibodies

AB2739

Anti-O-Linked N-Acetylglucosamine antibody [RL2]

Immunocytochemistry/ Immunofluorescence - Anti-O-Linked N-Acetylglucosamine antibody [RL2] (AB2739)

  • 5
  • 18
Primary Antibodies

AB16667

Anti-Ki67 antibody [SP6]

BOND RX™ Validated|KO Validated|RabMAb|Advanced Validation|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody [SP6] (AB16667)

  • 5
  • 133
Primary Antibodies

AB112995

Anti-Calnexin antibody [6F12BE10]

BOND RX™ Validated|KO Validated

Western blot - Anti-Calnexin antibody [6F12BE10] (AB112995)

  • 2
  • 2
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

C16orf48 also known as FLJ20489 is a protein with an approximate molecular mass of 13 kDa. It exhibits higher expression levels in certain tissues including the brain and liver indicating a tissue-specific role. The protein's mechanical function involves RNA binding suggesting its involvement in RNA processing or regulation. The well-defined binding domain aids in precise targeting within the cellular environment reinforcing its regulatory capacities.
Biological function summary

The actions of C16orf48 influence cellular processes particularly in gene expression regulation. C16orf48 participates in a multi-protein complex suggesting its interactions with other macromolecules elevate its functional significance. While not all the protein interactions and functions are thoroughly characterized its ability to bind RNA points towards an important role in post-transcriptional modifications or other RNA-related activities affecting how genes are expressed or silenced in different conditions.

Pathways

C16orf48 is implicated in pathways linked to RNA metabolic processes and gene expression regulation. Evidence shows involvement in the mRNA splicing pathway where it potentially interacts with well-studied splicing factors. The presence of related proteins like U2AF2 or SF3B1 within these pathways suggests that C16orf48 might influence alternative splicing events which can change the protein output from genes and lead to variations in cellular functions.

Mutations or dysregulation of C16orf48 have been associated with neurological disorders and liver diseases. In particular aberrant expression of C16orf48 can have implications in conditions such as Alzheimer's disease where connection to proteins like tau or amyloid precursor protein (APP) suggests a regulatory role in their gene expression. Additionally liver disease connections have drawn attention towards C16orf48's potential impact in hepatocyte function making it an important target for further research in understanding complex disease mechanisms.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Microtubule-binding protein which regulates microtubule organization and stability (PubMed : 35072334, PubMed : 35197565). Promotes the stability of astral microtubules and facilitates the proper orientation of the mitotic spindle (PubMed : 35197565). This allows the oriented division of basal keratinocytes and contributes to epidermal stratification (By similarity). Required for the assembly of both primary and motile cilia (PubMed : 35301795). Destabilizes the interaction between CCP110 and CEP97 by competing with CEP97 for binding to CCP110 which promotes the removal of CCP110 and CEP97 from the mother centriole and allows the initiation of ciliogenesis (PubMed : 35301795).
See full target information ENKD1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The EMBO journal 40:e106336 PubMed33595114

2021

NHP2 downregulation counteracts hTR-mediated activation of the DNA damage response at ALT telomeres.

Applications

Unspecified application

Species

Unspecified reactive species

Maya Raghunandan,Dan Geelen,Eva Majerova,Anabelle Decottignies
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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