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AB241985

Anti-C5orf25 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal C5orf25 antibody. Suitable for IP and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human SIMC1 aa 1-100.

대체 명칭 보기

C5orf25, PLEIAD, SIMC1, SUMO-interacting motif-containing protein 1, Platform element for inhibition of autolytic degradation

1 이미지
Immunoprecipitation - Anti-C5orf25 antibody (AB241985)
  • IP

Supplier Data

Immunoprecipitation - Anti-C5orf25 antibody (AB241985)

C5orf25 was immunoprecipitated from HEK-293T (human epithelial cell line from embryonic kidney transformed with large T antigen) whole cell lysate (1.0 mg per IP reaction; 20% of IP loaded) using ab241985 at 8 μL per reaction. Western blot was performed from the immunoprecipitate using ab241985 at 1/1000 dilution.

Lane 1 : ab241985 IP in HEK-293T whole cell lysate.
Lane 2 : Control IgG in HEK-293T whole cell lysate.

Detection : Chemiluminescence with an exposure time of 30 seconds.

Lysates prepared in NETN buffer.

All lanes:

Immunoprecipitation - Anti-C5orf25 antibody (ab241985)

Predicted band size: 97 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IP

applications

Immunogen

Synthetic Peptide within Human SIMC1 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

Q8NDZ2

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보완 제품

Primary Antibodies

AB155495

Anti-SMC6 antibody

Immunocytochemistry/ Immunofluorescence - Anti-SMC6 antibody (AB155495)

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Primary Antibodies

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Anti-Coronin 1a/TACO antibody [EPR19467-143] - BSA and Azide free (Detector)

RabMAb|Recombinant

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Cell Lines & Lysates

AB266978

Human PLEKHA4 knockout A549 cell line

Sanger Sequencing - Human PLEKHA4 knockout A549 cell line (AB266978)

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Primary Antibodies

AB283946

Anti-SARS-CoV-2 Spike Glycoprotein S1 (RBD) antibody [EPR24852-174]

20ul selling size|RabMAb|Recombinant

Indirect ELISA - Anti-SARS-CoV-2 Spike Glycoprotein S1 (RBD) antibody [EPR24852-174] (AB283946)

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  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "testedAndGuaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p>8 - 15 μl/mg lysate</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
Antibody was affinity purified using an epitope specific to C5orf25 immobilized on solid support.
보관 버퍼
pH: 6.8 - 7.4 Preservative: 0.09% Sodium azide Constituents: Tris buffered saline, 0.1% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

C5orf25 also known as Chromosome 5 open reading frame 25 is a protein with a molecular weight of approximately 17 kDa. This protein shows expression in various tissues with notable presence in the brain and heart. C5orf25 has no definitive enzymatic function identified yet but studies suggest it might play roles in cellular processes through potential interactions with other cellular components. Understanding the mechanical role of C5orf25 remains an active area of research.
Biological function summary

This protein contributes to intracellular functions although not clearly defined. C5orf25 may partake in cellular signaling or structural integrity within specific cells. It does not appear as part of any well-characterized protein complex currently suggesting that it might function independently or as part of transient interactions in cellular biology. This protein’s biological roles could influence how cells respond to stress or maintain their regular operations.

Pathways

Researchers have begun mapping its interactions to various cellular processes. Current findings suggest potential links to signal transduction pathways such as the MAPK signaling. In this context it might interact indirectly with proteins like ERK and MEK known for regulating cell growth and differentiation. Although these connections are still theoretical they form the basis for further investigations into how C5orf25 fits into broader cellular networks.

Researchers have explored links between C5orf25 and neurological conditions. Some studies propose that variations in this protein might associate with neurodevelopmental disorders alongside proteins like DISC1. Furthermore altered expression levels of C5orf25 in cardiac tissues have drawn attention to possible involvement in heart diseases. Understanding these associations could help develop biomarkers or novel therapeutic targets leveraging the relationship between C5orf25 and disease pathways.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Plays a role in SMC5-SMC6 complex recruitment for viral restriction. Forms a complex with SLF2 and this complex is required to recruit SMC5-SMC6 complex to PML nuclear bodies and sites of viral replication.. Isoform 1. Inhibits the protease activity of CAPN3.. Isoform 5. Inhibits the protease activity of CAPN3.
See full target information SIMC1
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

eLife 11: PubMed36373674

2022

The Nse5/6-like SIMC1-SLF2 complex localizes SMC5/6 to viral replication centers.

Applications

Unspecified application

Species

Unspecified reactive species

Martina Oravcová,Minghua Nie,Nicola Zilio,Shintaro Maeda,Yasaman Jami-Alahmadi,Eros Lazzerini-Denchi,James A Wohlschlegel,Helle D Ulrich,Takanori Otomo,Michael N Boddy

Frontiers in cell and developmental biology 7:351 PubMed31921861

2019

Role of TGF-β/Smad Pathway in the Transcription of Pancreas-Specific Genes During Beta Cell Differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Yuhua Gao,Ranxi Zhang,Shanshan Dai,Xue Zhang,Xiangchen Li,Chunyu Bai
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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