AB184778

Anti-C6orf134/TAT antibody

Name: Anti-C6orf134/TAT antibody
Brand: Abcam Limited
SKU: AB184778
Rating: 4 (1 reviews)

(1 리뷰)

(4 제품이 사용된 논문 )

Rabbit Polyclonal C6orf134/TAT antibody. Suitable for IHC-P and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ATAT1 aa 100-200.

대체 명칭 보기

C6orf134, MEC17, Nbla00487, ATAT1, Alpha-tubulin N-acetyltransferase 1, Alpha-TAT, Alpha-TAT1, TAT, Acetyltransferase mec-17 homolog

1 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf134/TAT antibody (AB184778)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf134/TAT antibody (AB184778)

Immunohistochemical analysis of paraffin-embedded Human kidney tissue labeling C6orf134/TAT with ab184778 at 1/200 dilution.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human ATAT1 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q5SQI0

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

C6orf134 also known as TAT codes for a protein that functions in enzymatic activity catalyzing chemical reactions within cells. This protein has a molecular mass of approximately 59 kDa. It is found expressed in a variety of tissues but shows higher expression in liver tissue. Its enzymatic role involves processes that rely on its catalytic ability impacting cell metabolism and energy regulation.

Biological function summary

The enzyme affects metabolic pathways and amino acid metabolism. It plays a part in the conversion of specific substrates within these systems balancing energy flow and the availability of key metabolites. It can function as either an isolated enzyme or as part of larger enzymatic complexes depending on the cellular environment and metabolic demands.

Pathways

C6orf134 is deeply involved in the urea cycle and gluconeogenesis. These pathways play a critical role in managing nitrogen disposal and producing glucose when energy is needed. The enzyme operates alongside proteins such as carbamoyl phosphate synthetase 1 in the urea cycle and is related to phosphoenolpyruvate carboxykinase in gluconeogenesis affecting both nitrogen balance and glucose production.

Deficiencies or dysregulations of the enzyme relate to metabolic disorders such as tyrosinemia and hyperammonemia. These conditions connect C6orf134 to proteins like fumarylacetoacetate hydrolase and ornithine transcarbamylase as they are part of the metabolic networks disrupted in these disorders. Studying these connections helps understand how metabolic imbalances lead to disease symptoms.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.

See full target information ATAT1

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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Experimental & molecular medicine 57:1064-1077 PubMed40335634

2025

Acetylation of α-tubulin restores endothelial cell injury and blood-brain barrier disruption after intracerebral hemorrhage in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Xuejiao Lei,Eryi Sun,Xufang Ru,Yulian Quan,Xuezhu Chen,Qian Zhang,Yougling Lu,Qianying Huang,Yujie Chen,Wenyan Li,Hua Feng,Yang Yang,Rong Hu

Global medical genetics 10:388-394 PubMed38116489

2023

Integrative Analysis of to Identify a Novel Biomarker for Pancreatic Ductal Adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Yaoxian Xiang,Li Wang,Yurong Cheng,Huanjuan An,Chan Zhang,Jing Wang,Yingying Tong,Dong Yan

CNS neuroscience & therapeutics 29:2327-2338 PubMed36965035

2023

Acetylated α-tubulin alleviates injury to the dendritic spines after ischemic stroke in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Chuanyan Yang,Xuezhu Chen,Chenxu Zhang,Xuejiao Lei,Yongling Lu,Yuhai Wang,Hua Feng,Tunan Chen,Yang Yang

Journal of neurochemistry 160:51-63 PubMed34407220

2021

MEC17-induced α-tubulin acetylation restores mitochondrial transport function and alleviates axonal injury after intracerebral hemorrhage in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Yang,Xuezhu Chen,Zhizhong Feng,Xianfeng Cai,Xiaoming Zhu,Ming Cao,Likun Yang,Yujie Chen,Yuhai Wang,Hua Feng

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-C6orf134/TAT antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf134/TAT antibody (AB184778)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (4)

Product promise