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AB151066

Anti-C6orf203 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal C6orf203 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human MTRES1 aa 50-200.

대체 명칭 보기

C6orf203, HSPC230, MTRES1, Mitochondrial transcription rescue factor 1

5 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf203 antibody (AB151066)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf203 antibody (AB151066)

Paraffin embedded human prostate tissue s stained for C6orf203 using ab151066 at 1/500 dilution in immunohistochemical analysis.

Heat mediated antigen retrieval was performed with citrate buffer pH 6 before IHC staining protocol was commenced.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf203 antibody (AB151066)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf203 antibody (AB151066)

Paraffin embedded human testis tissue s stained for C6orf203 using ab151066 at 1/500 dilution in immunohistochemical analysis.

Heat mediated antigen retrieval was performed with citrate buffer pH 6 before IHC staining protocol was commenced.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf203 antibody (AB151066)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf203 antibody (AB151066)

Paraffin embedded human kidney tissue stained for C6orf203 using ab151066 at 1/500 dilution in immunohistochemical analysis.

Heat mediated antigen retrieval was performed with citrate buffer pH 6 before IHC staining protocol was commenced.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf203 antibody (AB151066)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C6orf203 antibody (AB151066)

Paraffin embedded human rectum tissue s stained for C6orf203 using ab151066 at 1/500 dilution in immunohistochemical analysis.

Heat mediated antigen retrieval was performed with citrate buffer pH 6 before IHC staining protocol was commenced.

Western blot - Anti-C6orf203 antibody (AB151066)
  • WB

Supplier Data

Western blot - Anti-C6orf203 antibody (AB151066)

Lane 1:

Western blot - Anti-C6orf203 antibody (ab151066)

Lane 2:

Western blot - Anti-C6orf203 antibody (ab151066) at 0.4 µg/mL

All lanes:

RT4 cell lysate

Predicted band size: 28 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human MTRES1 aa 50-200. The exact immunogen used to generate this antibody is proprietary information.

Q9P0P8

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

C6orf203 also known as Chromosome 6 Open Reading Frame 203 is a protein that potentially plays a role in cellular processes. This protein has a mass of around 45 kDa. Researchers have detected C6orf203 expression in several tissues including the heart brain and skeletal muscle suggesting it might have diverse functional roles in the human body. The exact mechanical function of C6orf203 remains under investigation but it seems to interact with components critical for cellular structure and function.
Biological function summary

C6orf203 takes part in regulating cellular stability and structural integrity. It might function in a multiprotein complex although the details of these interactions require further research. Evidence indicates its involvement in maintaining cellular homeostasis which suggests that it helps in processes related to cellular responses to physiological conditions. Within cellular contexts C6orf203 possibly manages interactions between cytoskeletal elements to preserve the structural dynamics of cells.

Pathways

Researchers consider the role of C6orf203 significant in cellular signaling and structural pathways. It potentially interacts with the cytoskeletal stabilization pathway which is essential for maintaining cell integrity. Through this pathway C6orf203 may engage with proteins like Actin and Tubulin contributing to cellular structure. By modulating these pathways C6orf203 facilitates the uniform functioning of cellular growth and morphology.

C6orf203 might relate to neurological and muscular disorders. Research suggests potential connections to two conditions: Parkinson’s disease and muscular dystrophies which may involve issues with cellular integrity and stability. In these diseases proteins like α-Synuclein and Dystrophin might also interact or influence the functional effects of C6orf203. Understanding these relations further will aid in elucidating the contribution of C6orf203 to disease mechanisms.

제품 프로토콜

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타겟 정보

Mitochondrial RNA-binding protein involved in mitochondrial transcription regulation. Functions as a protective factor to maintain proper mitochondrial RNA level during stress. Acts at the transcription level and its protective function depends on its RNA binding ability (PubMed : 31226201). Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation (PubMed : 31396629, PubMed : 33243891). As heterodimer with MTRF, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue (PubMed : 33243891).
See full target information MTRES1

제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

EMBO reports 24:e57228 PubMed37818824

2023

Tetracyclines activate mitoribosome quality control and reduce ER stress to promote cell survival.

Applications

Unspecified application

Species

Unspecified reactive species

Conor T Ronayne,Thomas D Jackson,Christopher F Bennett,Elizabeth A Perry,Noa Kantorovic,Pere Puigserver

Cancer cell international 22:231 PubMed35854294

2022

Depleting TMED3 alleviates the development of endometrial carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Jin Zhang,Yue Qi
제품이 사용된 논문 모두 보기

Product promise

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