JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB131135

Anti-Cadherin like 23 antibody

Be the first to review this product! 리뷰 제출

|

(2 제품이 사용된 논문 )

Rabbit Polyclonal Cadherin like 23 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 2 publications.

대체 명칭 보기

KIAA1774, KIAA1812, UNQ1894/PRO4340, CDH23, Cadherin-23, Otocadherin

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cadherin like 23 antibody (AB131135)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cadherin like 23 antibody (AB131135)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human spleen tissue labelling Cadherin like 23 with ab131135 at 1/100 dilution.

Immunocytochemistry/ Immunofluorescence - Anti-Cadherin like 23 antibody (AB131135)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-Cadherin like 23 antibody (AB131135)

Immunofluorescence analysis of HeLa cells labelling Cadherin like 23 with ab131135 at 1/100 dilution. The picture on the right is treated with immunising peptide.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

style
left-column

보완 제품

Primary Antibodies

AB150386

Anti-Myosin VIIa/MYO7A antibody [EPR7497]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Myosin VIIa/MYO7A antibody [EPR7497] (AB150386)

  • 0
  • 0
Primary Antibodies

AB82714

Anti-USH2A antibody

  • 0
  • 0
Primary Antibodies

AB53233

Anti-Otoferlin antibody [13A9]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Otoferlin antibody [13A9] (AB53233)

  • 4
  • 3
Primary Antibodies

AB228684

Anti-AIP antibody

Immunocytochemistry/ Immunofluorescence - Anti-AIP antibody (AB228684)

  • 0
  • 0
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/500", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Cadherin like 23 also known as CDH23 or otocadherin is a protein with a mass of approximately 335 kDa. This protein is a member of the cadherin superfamily and acts mechanically to mediate calcium-dependent cell-cell adhesion. It is important for maintaining the structure and function of hair cells in the inner ear where it is highly expressed. Additionally CDH23 is present in other tissues such as the retina highlighting its role in sensory organs.
Biological function summary

Cadherin like 23 contributes to the organization and maintenance of stereocilia which are actin-filled protrusions important for mechanotransduction in cochlear hair cells. CDH23 forms part of the tip link complex that connects stereocilia enabling the conversion of mechanical stimuli into electrical signals. Its involvement in forming this complex illustrates its essential role in auditory function and cellular communication.

Pathways

Cadherin like 23 is involved in essential biological processes linked to calcium signaling and the auditory transduction pathway. It interacts with other proteins such as myosin VIIA and protocadherin 15 which are critical for hair cell function and hearing. The protein plays a role in the mechanotransduction channel activity contributing to the regulation of ion influx that triggers auditory perception.

Mutational defects in Cadherin like 23 have been associated with Usher syndrome type 1D and non-syndromic sensorineural deafness (DFNB12). CDH23 mutations lead to disrupted hair cell function resulting in hearing loss and balance disorders frequently seen in these conditions. The protein's connection to disease also involves another cadherin-related protein protocadherin 15 which shares overlapping roles in similar cellular pathways highlighting the intricate interplay of these proteins in auditory-related genetic disorders.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells. CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development. It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells. Required for normal hearing.
See full target information CDH23
style
left-column

제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cancer biology & therapy 23:150-162 PubMed35130111

2022

The Anti-fibrosis drug Pirfenidone modifies the immunosuppressive tumor microenvironment and prevents the progression of renal cell carcinoma by inhibiting tumor autocrine TGF-β.

Applications

Unspecified application

Species

Unspecified reactive species

Gang Wang,Xiaowan Zhou,Zengli Guo,Nan Huang,Juan Li,Yanfang Lv,Lulu Han,Wei Zheng,Dandan Xu,Dafei Chai,Huizhong Li,Liantao Li,Junnian Zheng

International journal of molecular sciences 23: PubMed35163494

2022

Usher Syndrome Belongs to the Genetic Diseases Associated with Radiosensitivity: Influence of the ATM Protein Kinase.

Applications

Unspecified application

Species

Unspecified reactive species

Joëlle Al-Choboq,Mélanie L Ferlazzo,Laurène Sonzogni,Adeline Granzotto,Laura El-Nachef,Mira Maalouf,Elise Berthel,Nicolas Foray
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com