AB140131

Anti-Calcipressin 1/RCAN1 antibody [EPR8911]

Name: Anti-Calcipressin 1/RCAN1 antibody [EPR8911]
Brand: Abcam Limited
SKU: AB140131
Rating: 3 (1 reviews)

RabMAb
Recombinant
각 태그의 뜻

(1 리뷰)

(6 제품이 사용된 논문 )

Rabbit Recombinant Monoclonal Calcipressin 1/RCAN1 antibody. Suitable for WB and reacts with Human samples. Cited in 6 publications.

1 이미지

Unknown

Western blot - Anti-Calcipressin 1/RCAN1 antibody [EPR8911] (AB140131)

All lanes:

Western blot - Anti-Calcipressin 1/RCAN1 antibody [EPR8911] (ab140131) at 1/10000 dilution

All lanes:

Human fetal heart lysate at 10 µg

Secondary

All lanes:

HRP labelled goat anti-rabbit at 1/2000 dilution

Predicted band size: 28 kDa

false

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR8911

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/10000 - 1/50000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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제품 세부 정보

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

배송 시 보관 조건

Conditional Ambient

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Calcipressin 1 also known as RCAN1 is a protein that plays a central role in regulating calcineurin activity. This protein weighs around 29-31 kDa. It is found in various human tissues especially in the heart brain and skeletal muscle. By binding to calcineurin RCAN1 inhibits its phosphatase activity influencing cellular pathways that rely on calcium signaling.

Biological function summary

Within the cell RCAN1 functions as a modulator of calcineurin-dependent transcriptional activity. It interacts with several proteins including those in the signaling complex linked to the NFAT (nuclear factor of activated T-cells). By managing the activity of calcineurin RCAN1 influences the transcription of genes involved in growth development and immune responses. Therefore its role is critical in maintaining cellular homeostasis and response to changes in calcium levels.

Pathways

RCAN1 impacts the calcineurin-NFAT signaling and MAPK (mitogen-activated protein kinase) pathways. In the calcineurin-NFAT pathway RCAN1 influences T-cell activation and the immune response by modulating NFAT's transcriptional activity. Moreover the MAPK pathway which is important for cell proliferation and differentiation sees regulation through RCAN1's action on calcineurin interfacing with kinases like JNK (c-Jun N-terminal kinase) to adjust signaling outputs.

Alterations in RCAN1 expression or function associate with Down syndrome and Alzheimer's disease. Increased RCAN1 levels often seen in Down syndrome lead to reduced calcineurin function affecting neuronal signaling pathways. In Alzheimer's disease the interaction with proteins like Tau contributes to neurodegenerative processes. Understanding RCAN1's involvement provides insights into potential therapeutic targets for these conditions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A (PubMed : 12809556). Could play a role during central nervous system development (By similarity).

See full target information RCAN1

대체 명칭 보기

ADAPT78, CSP1, DSC1, DSCR1, RCAN1, Calcipressin-1, Adapt78, Down syndrome critical region protein 1, Myocyte-enriched calcineurin-interacting protein 1, Regulator of calcineurin 1, MCIP1

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제품이 사용된 논문 (6)

Recent publications for all applications. Explore the 전체 목록 and refine your search

World journal of gastroenterology 31:105554 PubMed40495950

2025

Multi-parameter magnetic resonance imaging of zebularine in liver fibrosis treatment and calcineurin/ mechanism.

Applications

Unspecified application

Species

Unspecified reactive species

Shi-Yi Lyu,Wang Xiao,Yan-Jing Chen,Qiu-Ling Liao,Ye-Yu Cai,Cheng Yu,Jia-Yi Liu,Huan Liu,Min-Ping Zhang,Yu-Lu Ren,Qi-Ling Yu,Yi-Ming Qi,En-Hua Xiao,Yong-Heng Luo

Cell death & disease 15:406 PubMed38858351

2024

Histone acetyltransferase Kat2a regulates ferroptosis via enhancing Tfrc and Hmox1 expression in diabetic cardiomyopathy.

Applications

Unspecified application

Species

Unspecified reactive species

Juan Zhen,Xia Sheng,Tianlong Chen,Haitao Yu

Cells 11: PubMed36429004

2022

Overexpression of , a Gene on Human Chromosome , Alters Cell Redox and Mitochondrial Function in Enamel Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Yi Li,Veronica Costiniti,Guilherme H Souza Bomfim,Maria Neginskaya,Ga-Yeon Son,Beverly Rothermel,Evgeny Pavlov,Rodrigo S Lacruz

Journal of bone oncology 30:100383 PubMed34336566

2021

RCAN1.4 suppresses the osteosarcoma growth and metastasis via interfering with the calcineurin/NFAT signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Bao Huang,Zenghui Jiang,Saishuang Wu,Hao Wu,Xuyang Zhang,Jian Chen,Fengdong Zhao,Junhui Liu

Experimental & molecular medicine 52:865-875 PubMed32467610

2020

The RCAN1.4-calcineurin/NFAT signaling pathway is essential for hypoxic adaption of intervertebral discs.

Applications

Unspecified application

Species

Unspecified reactive species

Bao Huang,Yongqing He,Shengwen Li,Xiaoan Wei,Junhui Liu,Zhi Shan,Yue Huang,Jian Chen,Fengdong Zhao

Physiological reports 6:e13912 PubMed30430766

2018

Effects of hypoestrogenism and/or hyperaldosteronism on myocardial remodeling in female mice.

Applications

Unspecified application

Species

Unspecified reactive species

Patricia Rouet-Benzineb,Régine Merval,Evelyne Polidano

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Calcipressin 1/RCAN1 antibody [EPR8911]

Western blot - Anti-Calcipressin 1/RCAN1 antibody [EPR8911] (AB140131)

관련 conjugated 항체와 다양한 조성의 항체 (1)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (6)

Product promise