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AB244602

Anti-Calcitonin antibody [EPR20408-37] - BSA and Azide free (Capture)

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Rabbit Recombinant Monoclonal Calcitonin antibody. Carrier free. Suitable for sELISA and reacts with Human samples.

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CALC1, CALCA, Calcitonin

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Sandwich ELISA - Anti-Calcitonin antibody [EPR20408-37] - BSA and Azide free (Capture) (AB244602)
  • sELISA

Supplier Data

Sandwich ELISA - Anti-Calcitonin antibody [EPR20408-37] - BSA and Azide free (Capture) (AB244602)

Representative standard curve from corresponding SimpleStep ELISA® Kit (ab279411).

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR20408-37

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

sELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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보완 제품

Assay Kits

AB221828

Human Procalcitonin ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human Procalcitonin ELISA Kit (AB221828)

  • 5
  • 1
Proteins & Peptides

AB316568

Recombinant Human Procalcitonin Protein Standard (His tag)

Sandwich ELISA - Recombinant Human Procalcitonin Protein Standard (His tag) (AB316568)

  • 0
  • 0
Primary Antibodies

AB259649

Anti-PDGFR beta antibody [EPR22290-256] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-PDGFR beta antibody [EPR22290-256] - BSA and Azide free (Capture) (AB259649)

  • 0
  • 0
Primary Antibodies

AB259576

Anti-MIP-3 beta/CCL19 antibody [EPR21965-72] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-MIP-3 beta/CCL19 antibody [EPR21965-72] - BSA and Azide free (Detector) (AB259576)

  • 0
  • 0
Primary Antibodies

AB252660

Anti-SNAP25 antibody [EPR20249-110] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-SNAP25 antibody [EPR20249-110] - BSA and Azide free (Capture) (AB252660)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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제품 세부 정보

ab244602 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human Calcitonin. The recommended pair for sandwich ELISA is:
Capture: ab244851 Human Calcitonin Capture Antibody (unconjugated)
Detector: ab244602, Human Calcitonin Detector Antibody (unconjugated)

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Sandwich ELISA
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Calcitonin also known as thyrocalcitonin is a peptide hormone with a molecular mass of about 3.4 kDa. It consists of 32 amino acids and is primarily synthesized in parafollicular cells or C cells of the thyroid gland. This hormone regulates calcium and phosphate homeostasis in the body. It reduces blood calcium levels by inhibiting osteoclast activity in the bones and decreasing reabsorption in the kidneys leading to more calcium excretion. Calcitonin also interacts with its receptor a G protein-coupled receptor found in tissues like bone kidney and brain.
Biological function summary

This hormone plays a significant role in maintaining calcium levels by balancing the actions of parathyroid hormone (PTH). Calcitonin works independently but interacts with the broader system managing bone remodeling through an intricate network. The presence of calcitonin in specialized receptor complexes allows it to exert its effects efficiently in target tissues making it an important player in calcium and phosphorus metabolism.

Pathways

Calcitonin acts within the calcium signaling pathway and the bone resorption pathway. Through these pathways calcitonin works alongside other proteins such as parathyroid hormone (PTH) and calcitonin gene-related peptide (CGRP) maintaining skeletal integrity. It modulates the activity of osteoclasts ensuring that bone resorption activities are counterbalanced by bone formation and influences intracellular calcium concentration by binding to its receptor on target cells.

Calcitonin is linked to conditions such as osteoporosis and medullary thyroid carcinoma. Osteoporosis characterized by decreased bone density and increased fracture risk involves dysregulated calcium and phosphate balance. Proteins like estrogen and growth factors along with calcitonin influence bone health. Medullary thyroid carcinoma a type of thyroid cancer arising from C cells affects calcitonin levels with this hormone serving as a biomarker for diagnosing and monitoring treatment effectiveness. Calcitonin's connection with these diseases highlights its diagnostic and therapeutic potential.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Calcitonin. Calcitonin is a peptide hormone that causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. Calcitonin function is mediated by the calcitonin receptor/CALCR and the CALCR-RAMP2 (AMYR2) receptor complex (PubMed : 35324283).. Katacalcin. Katacalcin is a potent plasma calcium-lowering peptide.
See full target information CALCA
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Product promise

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