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AB67714

Anti-CAMLG/CAML antibody

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Mouse Polyclonal CAMLG/CAML antibody. Suitable for WB and reacts with Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CAMLG.
1 이미지
Western blot - Anti-CAMLG/CAML antibody (AB67714)
  • WB

Unknown

Western blot - Anti-CAMLG/CAML antibody (AB67714)

All lanes:

Western blot - Anti-CAMLG/CAML antibody (ab67714) at 1/500 dilution

All lanes:

rat brain at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 33 kDa

Observed band size: 33 kDa

false

주요 정보

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat, Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CAMLG.

P49069

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대체품

Primary Antibodies

AB236655

Anti-CAMLG/CAML antibody

Immunocytochemistry/ Immunofluorescence - Anti-CAMLG/CAML antibody (AB236655)

  • 0
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보완 제품

Proteins & Peptides

AB167835

Recombinant Human CAMLG/CAML protein (His tag N-Terminus)

SDS-PAGE - Recombinant Human CAMLG/CAML protein (His tag N-Terminus) (AB167835)

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Primary Antibodies

AB275647

Anti-ATP12A antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ATP12A antibody (AB275647)

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  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
보관 버퍼
pH: 7.4 Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CAMLG also known as CAML (calcium modulating ligand) is a protein with a molecular mass of approximately 37 kDa. CAMLG has an essential role in cellular calcium signaling processes. It is predominantly expressed in the endoplasmic reticulum membrane in various cell types. CAMLG's function involves mediating calcium influx and maintenance which affects multiple cellular operations. The protein interacts with membrane-bound elements facilitating its role in signaling and cellular homeostasis.
Biological function summary

CAMLG contributes to proper cellular signaling and function by managing calcium flux. It is part of larger protein complexes that regulate calcium-dependent cellular activities. CAMLG assists in the modulation of intracellular calcium levels that influence processes like cell proliferation differentiation and apoptosis. As part of its complex interactions CAMLG collaborates with other proteins involved in calcium signal transduction.

Pathways

Cellular calcium homeostasis mechanisms feature CAMLG as a critical component. This protein functions within pathways such as the NFAT (nuclear factor of activated T-cells) signaling and IP3 (inositol 145-trisphosphate) pathway. In these systems CAMLG interacts with other proteins like IP3 receptor affecting the release and regulation of calcium ions which impact gene transcription and immune response.

Dysfunction in CAMLG activity relates to immune system irregularities and cancer. Disruption in calcium signaling pathways implicates CAMLG in conditions like autoimmune disorders affecting immune cell regulation. Abnormal expression or mutations in CAMLG may also contribute to cancerous cell proliferation when linked to proteins such as NFAT emphasizing its involvement in oncogenic pathways.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum (PubMed : 23041287, PubMed : 24392163, PubMed : 27226539). Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol (PubMed : 23041287, PubMed : 24392163, PubMed : 27226539). Required for the stability of GET1 (PubMed : 32187542). Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium (PubMed : 7522304). Essential for the survival of peripheral follicular B cells (By similarity).
See full target information CAMLG

대체 명칭 보기

CAML, GET2, CAMLG, Guided entry of tail-anchored proteins factor CAMLG, Calcium signal-modulating cyclophilin ligand
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature immunology 11:836-45 PubMed20676093

2010

The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88.

Applications

WB, ICC/IF

Species

Human, Human

Bing He,Raul Santamaria,Weifeng Xu,Montserrat Cols,Kang Chen,Irene Puga,Meimei Shan,Huabao Xiong,James B Bussel,April Chiu,Anne Puel,Jeanine Reichenbach,László Marodi,Rainer Döffinger,Julia Vasconcelos,Andrew Issekutz,Jens Krause,Graham Davies,Xiaoxia Li,Bodo Grimbacher,Alessandro Plebani,Eric Meffre,Capucine Picard,Charlotte Cunningham-Rundles,Jean-Laurent Casanova,Andrea Cerutti
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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