AB134901

Anti-cAMP antibody [EP8471]

Name: Anti-cAMP antibody [EP8471]
Brand: Abcam Limited
SKU: AB134901
Rating: 5 (2 reviews)

20ul selling size
RabMAb
Recombinant
각 태그의 뜻

(2 리뷰들)

(9 제품이 사용된 논문 )

Rabbit Recombinant Monoclonal cAMP antibody. Suitable for ELISA and reacts with Chemical samples. Cited in 9 publications.

대체 명칭 보기

3'-5'-cyclic adenosine monophosphate, Adenosine 3' 5' cyclic monophosphate, Adenosine 3閳 5閳 cyclic monophosphate, Cyclic adenosine monophosphate

1 이미지

ELISA - Anti-cAMP antibody [EP8471] (AB134901)

ELISA

Lab

ELISA - Anti-cAMP antibody [EP8471] (AB134901)

Competitive ELISA antigen dose-response graph using purified ab134901 (0.25 µg/mL). Antigen concentration of 0.1 µg/mL. 0.1 μg/mL antigen was coated. Free cAMP and other competitors (2.5 mg/mL) were added respectively. AffiniPure Goat Anti-Rabbit IgG FC-HRP (1/2500 dilution) was used as the secondary antibody.

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EP8471

Isotype

IgG

Carrier free

Applications

ELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

<p>This antibody does not cross react with cGMP, GMP, GDP, cIMP, cCMP, or adenosine.</p>

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Chemical": { "ELISA-species-checked": "testedAndGuaranteed", "ELISA-species-dilution-info": "0.25 mg/mL", "ELISA-species-notes": "<p></p>" } } }

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제품 세부 정보

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

배송 시 보관 조건

Conditional Ambient

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

보관 정보

Stable for 12 months at -20°C

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Cyclic adenosine monophosphate (cAMP) serves as an essential secondary messenger in various signal transduction pathways. Known also by its chemical abbreviation cAMP this small molecule has a mass of approximately 329.21 g/mol. cAMP is synthesized from ATP by the enzyme adenylate cyclase which is present in many cell types notably in neurons and various endocrine tissues. cAMP acts by activating protein kinase A (PKA) which then phosphorylates target proteins to alter cellular function.

Biological function summary

CAMP regulates numerous cellular processes including metabolism gene expression and cell growth. It functions as an important part of G protein-coupled receptor (GPCR) signaling pathways where its concentration can significantly change influenced by external signals. cAMP modulates the activity of ion channels and various enzymes often participating in feedback loops to maintain cellular homeostasis.

Pathways

CAMP integrates into critical signal transduction pathways such as the cyclic AMP-dependent pathway and the calcium signaling pathway. It works closely with proteins like CREB (cAMP response element-binding protein) to regulate gene transcription. cAMP also impacts other molecules like phosphodiesterases which break it down maintaining its transient nature in response to stimuli.

Irregular cAMP levels associate with pathologies like heart failure and certain types of cancer. Disruptions in cAMP signaling can lead to abnormal cell growth or inadequate cellular response to hormonal signals. Through its interaction with proteins like CFTR (cystic fibrosis transmembrane conductance regulator) cAMP influences disorders such as cystic fibrosis highlighting its critical role in maintaining cellular function and signaling balance.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

See full target information cAMP

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제품이 사용된 논문 (9)

Recent publications for all applications. Explore the 전체 목록 and refine your search

International journal of molecular sciences 25: PubMed39126032

2024

Anti-Inflammatory Effects of miR-369-3p via PDE4B in Intestinal Inflammatory Response.

Applications

Unspecified application

Species

Unspecified reactive species

Viviana Scalavino,Emanuele Piccinno,Nicoletta Labarile,Raffaele Armentano,Gianluigi Giannelli,Grazia Serino

Journal of cellular and molecular medicine 28:e18366 PubMed38856956

2024

Overexpression of olfactory receptor 78 ameliorates brain injury in cerebral ischaemia-reperfusion rats by activating Prkaca-mediated cAMP/PKA-MAPK pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Tao Kang,Lijuan Zhu,Yanli Xue,Qian Yang,Qi Lei,Qianqian Wang

Frontiers in pharmacology 15:1371929 PubMed38576483

2024

Xiasangju alleviate metabolic syndrome by enhancing noradrenaline biosynthesis and activating brown adipose tissue.

Applications

Unspecified application

Species

Unspecified reactive species

Changhao He,Yongcheng An,Lu Shi,Yan Huang,Huilin Zhang,Wanxin Fu,Menglu Wang,Ziyi Shan,Yuhang Du,Jiamei Xie,Zhiyun Huang,Weiguang Sun,Yonghua Zhao,Baosheng Zhao

eLife 12: PubMed37960975

2023

Astrocyte and L-lactate in the anterior cingulate cortex modulate schema memory and neuronal mitochondrial biogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Mastura Akter,Mahadi Hasan,Aruna Surendran Ramkrishnan,Zafar Iqbal,Xianlin Zheng,Zhongqi Fu,Zhuogui Lei,Anwarul Karim,Ying Li

Nature 622:383-392 PubMed37731001

2023

The β-adrenergic receptor links sympathetic nerves to T cell exhaustion.

Applications

Unspecified application

Species

Unspecified reactive species

Anna-Maria Globig,Steven Zhao,Jessica Roginsky,Vivien I Maltez,Juan Guiza,Natalia Avina-Ochoa,Maximilian Heeg,Filipe Araujo Hoffmann,Omkar Chaudhary,Jiawei Wang,Gokhan Senturk,Dan Chen,Carolyn O'Connor,Samuel Pfaff,Ronald N Germain,Kurt A Schalper,Brinda Emu,Susan M Kaech

Proceedings of the National Academy of Sciences of the United States of America 120:e2304168120 PubMed37603749

2023

Gap junction-transported cAMP from the niche controls stem cell progeny differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Renjun Tu,Xiaohan Alex Tang,Rui Xu,Zhaohua Ping,Zulin Yu,Ting Xie

International journal of nanomedicine 17:1549-1566 PubMed35401001

2022

Pseudoephedrine Nanoparticles Alleviate Adriamycin-Induced Reproductive Toxicity Through the GnRhR Signaling Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yang Fu,Peipei Yuan,Yajuan Zheng,Yaxin Wei,Liyuan Gao,Yuan Ruan,Yi Chen,Panying Li,Weisheng Feng,Xiaoke Zheng

Autophagy 16:2193-2205 PubMed32003282

2020

Microglial autophagy defect causes parkinson disease-like symptoms by accelerating inflammasome activation in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Jinbo Cheng,Yajin Liao,Yuan Dong,Han Hu,Nannan Yang,Xiangxi Kong,Shuoshuo Li,Xiaoheng Li,Jifeng Guo,Lixia Qin,Jiezhong Yu,Cungen Ma,Jianke Li,Mingtao Li,Beisha Tang,Zengqiang Yuan

Molecular medicine reports 20:2143-2150 PubMed31322181

2019

Pinoresinol promotes MC3T3‑E1 cell proliferation and differentiation via the cyclic AMP/protein kinase A signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Jiang,Wenjing Chen,Fuguo Shen,Wenlong Xiao,Hongliang Guo,Hang Su,Jiang Xiu,Wencai Sun

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-cAMP antibody [EP8471]

ELISA - Anti-cAMP antibody [EP8471] (AB134901)

관련 conjugated 항체와 다양한 조성의 항체 (1)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Applications

Immunogen

Specificity

보완 제품

Assay Kits

Primary Antibodies

Primary Antibodies

Primary Antibodies

Assay Kits

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (9)

Product promise