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AB199116

Anti-CAMTA1 antibody

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(1 출판물)

Rabbit Polyclonal CAMTA1 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CAMTA1.

대체 명칭 보기

KIAA0833, MSTP023, CAMTA1, Calmodulin-binding transcription activator 1

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAMTA1 antibody (AB199116)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAMTA1 antibody (AB199116)

Immunohistochemical analysis of paraffin-embedded Human colorectal cancer tissue using ab19916 at dilution 1/50.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAMTA1 antibody (AB199116)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAMTA1 antibody (AB199116)

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue using ab19916 at dilution 1/50.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human CAMTA1. The exact immunogen used to generate this antibody is proprietary information.

Q9Y6Y1

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/300", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }

제품 세부 정보

Calmodulin-binding transcription activator 1 is a protein that in humans is encoded by the CAMTA1 gene. Normally expressed in non-neoplastic adult central nervous system tissues: detected in whole brain, cerebellum, brain cortex, occipital lobe, frontal lobe, temporal lobe, putamen. Expression levels are low in oligodendroglial tumors, and are reduced by half in oligodendroglioma and astrocytoma cases with 1p loss of heterozygosity. Detected in neuroblastic-type cultured neuroblastoma cells.

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CAMTA1 also known as calmodulin-binding transcription activator 1 is a transcription factor with a mass of approximately 130 kDa. CAMTA1 plays an important role in gene regulation through its DNA-binding domain. This protein is highly expressed in the brain heart and skeletal muscle indicating its importance in these tissues. CAMTA1 contains a CG-1 DNA-binding domain ankyrin repeats and a calmodulin-binding IQ motif which help in its interaction with different cellular components.
Biological function summary

CAMTA1 regulates the expression of genes involved in the response to environmental stress and the development of neuronal and cardiac tissues. As part of a transcriptional regulatory complex CAMTA1 can recruit other co-factors to modulate gene expression. It influences processes such as neuronal differentiation and cardiac hypertrophy. Its expression pattern and transcriptional activity suggest that it helps maintain cellular homeostasis under varying physiological conditions.

Pathways

CAMTA1 has significant roles in two central biological pathways: calcium signaling and stress response pathways. These pathways are important for neuronal and cardiac function. In calcium signaling CAMTA1 acts alongside other proteins like calmodulin to modulate the expression of genes critical for calcium homeostasis. In stress response pathways it helps regulate genes that protect against cellular stress often collaborating with transcription factors such as MEF2C to mediate stress responses.

CAMTA1 is associated with neurodevelopmental disorders and cardiac diseases. Mutations or dysregulation of CAMTA1 expression might contribute to conditions such as ataxia and congenital heart defects. Studies have linked CAMTA1 with other proteins including MEF2C in the context of cardiac development issues suggesting a complex network of interactions essential for normal physiological function.

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

타겟 정보

Transcriptional activator.
See full target information CAMTA1

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cancers 12: PubMed32349388

2020

Integrative Transcriptome Analyses of the Human Fallopian Tube: Fimbria and Ampulla-Site of Origin of Serous Carcinoma of the Ovary.

Applications

Unspecified application

Species

Unspecified reactive species

Ramlogan Sowamber,Omar Nelson,Leah Dodds,Victoria DeCastro,Iru Paudel,Anca Milea,Michael Considine,Leslie Cope,Andre Pinto,Matthew Schlumbrecht,Brian Slomovitz,Patricia A Shaw,Sophia H L George
제품이 사용된 논문 모두 보기

Product promise

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