AB236590

Anti-CAP2 antibody

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(4 제품이 사용된 논문 )

Rabbit Polyclonal CAP2 antibody. Suitable for WB, IHC-P and reacts with Human, Mouse samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human Adenylyl cyclase-associated protein 2 aa 200-500.

대체 명칭 보기

Adenylyl cyclase-associated protein 2, CAP 2, CAP2

2 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAP2 antibody (AB236590)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAP2 antibody (AB236590)

Paraffin-embedded human heart tissue stained for CAP2 with ab236590 at a 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAP2 antibody (AB236590)

Paraffin-embedded human skeletal muscle tissue stained for CAP2 with ab236590 at a 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human Adenylyl cyclase-associated protein 2 aa 200-500. The exact immunogen used to generate this antibody is proprietary information.

P40123

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

Purity >95%.

보관 버퍼

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CAP2 also known as Cyclase Associated Protein 2 is a protein playing an essential role in actin dynamics. It has a molecular mass of approximately 54 kDa. Researchers have detected its expression in various tissues including the heart skeletal muscle and brain. CAP2 influences the organization of the cytoskeleton by binding to actin filaments and regulating their polymerization and depolymerization. Its activity makes it an important player in cell motility and structure maintenance.

Biological function summary

CAP2 contributes to cellular processes by modulating actin filament turnover and facilitating actin recycling. It operates as part of a protein complex that includes other actin-binding proteins often working in tandem with profilin and cofilin. This complex formation is integral to the regulation of cytoskeletal organization impacting important cellular functions like cell division intracellular transport and signal transduction.

Pathways

CAP2 is an active participant in pathways controlling cell movement and structural integrity particularly the actin cytoskeleton signaling pathway. In this role CAP2 interacts with proteins such as cofilin which also modulates actin dynamics to maintain a balance of actin filament assembly and disassembly. Another pathway CAP2 is involved in is the cell adhesion pathway where it helps facilitate the dynamic remodeling necessary for cell attachment and migration.

CAP2 has been linked to cardiac diseases and cancer. Alterations in CAP2 expression have been associated with the development of dilated cardiomyopathy a condition marked by weakened heart muscle functionality. Furthermore CAP2 has demonstrated interactions with p53 a protein often mutated in cancers implicating it in processes that may contribute to tumor growth and metastasis. These connections reveal its importance not only in normal cellular function but also in pathological states.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Involved in the regulation of actin polymerization.

See full target information Adenylyl cyclase-associated protein 2

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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Discover oncology 16:1253 PubMed40601174

2025

Mitochondrial pyruvate carrier inhibits tumor growth by Bmi1 ubiquitination in renal cell carcinoma progression.

Applications

Unspecified application

Species

Unspecified reactive species

Dan Jian,Nana Hu,Rong He,Le He,He Xiao,Xingqiao Peng,Yang Peng,Yuxin Yang,Xiaoyan Dai,Dong Wang,Yan Feng,Nan Dai,Qian Chen

International journal of molecular medicine 48: PubMed34414454

2021

MicroRNA‑28‑3p inhibits angiotensin‑converting enzyme 2 ectodomain shedding in 293T cells treated with the spike protein of severe acute respiratory syndrome coronavirus 2 by targeting A disintegrin and metalloproteinase 17.

Applications

Unspecified application

Species

Unspecified reactive species

Yun Xu,Yi Li

Journal of gastrointestinal oncology 12:268-277 PubMed34012625

2021

CAP2 contributes to tumorigenesis in gastric cancer by targeting transcription factor SOX9.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Wan,Shengkui Qiu,Lei Yin,Xuesong Gao,Yasu Jiang,Shichun Feng,Chong Tang

Nan fang yi ke da xue xue bao = Journal of Southern Medical University 39:1052-1058 PubMed31640951

2019

[Association of adenylate cyclase-associated protein 2 expression with histopathology and long-term prognosis of gastric cancer].

Applications

Unspecified application

Species

Unspecified reactive species

Sitang Ge,Shan Wang,Wujun Xiang,Lili Wang,Yuke Zhu,Xiang Zhu,Xun Wang,Lugen Zuo,Congqiao Jiang,Siqing Li,Mulin Liu

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CAP2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAP2 antibody (AB236590)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CAP2 antibody (AB236590)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (4)

Product promise