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AB285097

Anti-Cathepsin Z antibody [EPR24460-104] - BSA and Azide free (Detector)

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Anti-Cathepsin Z antibody [EPR24460-104] - BSA and Azide free (Detector) (ab285097) is a rabbit recombinant monoclonal antibody provided in a PBS only buffer for easy conjugation detecting Cathepsin Z in ELISA. Suitable for Human.

- BSA, sodium azide, and glycerol-free for easy conjugation
- Biophysical QC for unrivalled batch-batch consistency
1 이미지
Sandwich ELISA - Anti-Cathepsin Z antibody [EPR24460-104] - BSA and Azide free (Detector) (AB285097)
  • sELISA

Supplier Data

Sandwich ELISA - Anti-Cathepsin Z antibody [EPR24460-104] - BSA and Azide free (Detector) (AB285097)

Example of Human Cathepsin Z standard curve. Background-subtracted data values (mean +/- SD) are graphed.

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR24460-104

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

sELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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보완 제품

Assay Kits

AB287165

Human Cathepsin Z ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human Cathepsin Z ELISA Kit (AB287165)

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  • 0
Sample Prep & Detection Kits

AB269822

Alexa Fluor® 594 Conjugation Kit (Fast) - Lightning-Link®

Schematic Diagram - Alexa Fluor® 594 Conjugation Kit (Fast) - Lightning-Link® (AB269822)

  • 5
  • 1
Sample Prep & Detection Kits

AB269902

Gold-Maleimide Conjugation Kit (20nm, 20 OD)

Lateral flow assay - Gold-Maleimide Conjugation Kit (20nm, 20 OD) (AB269902)

  • 0
  • 0
Primary Antibodies

AB285132

Anti-Semaphorin 4D/CD100 antibody [EPR23866-52] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-Semaphorin 4D/CD100 antibody [EPR23866-52] - BSA and Azide free (Detector) (AB285132)

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  • 0
Primary Antibodies

AB278348

Anti-HRG antibody [EPR24184-134] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-HRG antibody [EPR24184-134] - BSA and Azide free (Capture) (AB278348)

  • 0
  • 0
Primary Antibodies

AB305123

Anti-S100A11 antibody [EPR25825-112] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-S100A11 antibody [EPR25825-112] - BSA and Azide free (Detector) (AB305123)

  • 0
  • 0
Primary Antibodies

AB245045

Anti-PLA2G7 antibody [EPR20360-245] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-PLA2G7 antibody [EPR20360-245] - BSA and Azide free (Detector) (AB245045)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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제품 세부 정보

ab285097 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human Cathepsin Z. The recommended pair for sandwich ELISA is:
Capture: ab284991, Human Cathepsin Z Capture Antibody (unconjugated)
Detector: ab285097, Human Cathepsin Z Detector Antibody (unconjugated)
The reference range value is 0.156 - 10 ng/mL.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Sandwich ELISA
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Cathepsin Z also known as cathepsin X or CTSZ is a lysosomal cysteine protease with a molecular weight of approximately 34 kDa. It is expressed mainly in immune cells such as macrophages and dendritic cells but also found in other tissues including liver kidney and spleen. This protease performs proteolytic functions which involve cleaving peptide bonds in proteins contributing to protein catabolism in cells. The widespread expression of Cathepsin Z suggests its involvement in various physiological processes.
Biological function summary

Cathepsin Z participates in immune response regulation and cellular adhesion processes. It belongs to the papain-like cysteine protease family. Notably it associates with integrins to influence cell-extracellular matrix interactions affecting cell migration and adhesion. By modulating these processes Cathepsin Z impacts immune surveillance and tissue remodeling demonstrating its multifaceted role in maintaining cellular homeostasis.

Pathways

Cathepsin Z engages significantly in apoptotic and antigen-presenting pathways. In apoptosis it influences cell death by degrading specific substrates involved in cell survival. It also assists in the processing of antigens within dendritic cells facilitating effective antigen presentation to T cells. Related proteins such as Cathepsin S and Cathepsin L which also partake in lysosomal pathways further illustrate the shared functionality and redundancy within this protease family enabling a robust regulatory network.

Cathepsin Z has implications in cancer progression and neurodegenerative diseases. It is often overexpressed in cancerous tissues where it aids tumor cell invasion and metastasis through degradation of extracellular components. Additionally alterations in Cathepsin Z activity are linked to Alzheimer's disease where it may affect the processing of amyloid precursor proteins similar to its interaction with other proteins like Cathepsin B. These connections highlight the potential for Cathepsin Z as a target for therapeutic intervention in various pathological conditions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity (PubMed : 10504234). Capable of producing kinin potentiating peptides (By similarity).
See full target information Cathepsin Z

대체 명칭 보기

Cathepsin Z, Cathepsin P, Cathepsin X, CTSZ
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Product promise

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