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AB244512

Anti-CCP1 antibody

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Rabbit Polyclonal CCP1 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human AGTPBP1 aa 1000 to C-terminus.

대체 명칭 보기

CCP1, KIAA1035, NNA1, AGTPBP1, Cytosolic carboxypeptidase 1, ATP/GTP-binding protein 1, Nervous system nuclear protein induced by axotomy protein 1 homolog, Protein deglutamylase CCP1

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCP1 antibody (AB244512)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCP1 antibody (AB244512)

Paraffin-embedded human testis tissue stained for CCP1 using ab244512 at 1/200 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-CCP1 antibody (AB244512)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CCP1 antibody (AB244512)

PFA-fixed, Triton X-100 permeabilized U-2 OS (human bone osteosarcoma epithelial cell line) cells stained for CCP1 (green) using ab244512 at 4 μg/ml in ICC/IF.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human AGTPBP1 aa 1000 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9UPW5

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보완 제품

Primary Antibodies

AB315452

Anti-CerS2 antibody [EPR28098-1]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CerS2 antibody [EPR28098-1] (AB315452)

  • 0
  • 0
Primary Antibodies

AB3982

Anti-CA19-9 antibody [121SLE]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CA19-9 antibody [121SLE] (AB3982)

  • 2
  • 1
Primary Antibodies

AB184169

Anti-Germinal Center Kinase/GCK antibody [EPR14304]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Germinal Center Kinase/GCK antibody [EPR14304] (AB184169)

  • 0
  • 0
Primary Antibodies

AB17050

Anti-Calprotectin (S100A8 + S100A9) antibody [27E10]

Immunohistochemistry (Frozen sections) - Anti-Calprotectin (S100A8 + S100A9) antibody [27E10] (AB17050)

  • 5
  • 2
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CCP1 also known as Cytosolic Carboxypeptidase 1 is an enzymatic protein important in the modulation of microtubule function. This protein is approximately 76 kDa in mass and is mainly expressed in the brain and testes but it can be found in other tissues as well. CCP1 acts by trimming the C-terminal amino acids of tubulin and other substrates impacting their stability and function. This modification plays a role in determining microtubule dynamics which are important for cell shape division and intracellular transport.
Biological function summary

CCP1 contributes to maintaining cellular functions by removing glutamates from the C-terminal of tubulin impacting microtubule behavior. It forms part of the tubulin tyrosination-detyrosination cycle and interacts with other proteins within the cycle to regulate microtubule length and stability. This regulation is essential for the proper operation of neuronal cells and can influence processes like axonal transport and signaling.

Pathways

CCP1's enzymatic activity links to microtubule and cellular cytoskeleton organization pathways. It influences the dynamic instability of microtubules essential in cell division and intracellular traffic. CCP1 interacts with other tubulin-modifying enzymes like CCP5 which together modify microtubule attributes through polyglutamylation and serve roles in cell motility and structural integrity.

CCP1 alterations or mutations have associations with neurodegenerative disorders and certain forms of cancer. Its dysfunction can lead to the progressive degeneration of neurons connected to Ataxia a condition affecting motor control. Additionally CCP1 mutations or disruptions can link to tubulin-binding proteins contributing to unregulated cell proliferation seen in some cancers. Understanding CCP1's role in these conditions can guide therapeutic strategies targeting these proteins and pathways.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins (PubMed : 22170066, PubMed : 24022482, PubMed : 30420557). Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of alpha- and beta-tubulin (PubMed : 22170066, PubMed : 24022482, PubMed : 30420557). Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate (PubMed : 24022482). Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of alpha-tubulin as well as non-tubulin proteins such as MYLK (PubMed : 22170066). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis (PubMed : 29593216).
See full target information AGTPBP1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Viruses 17: PubMed40431628

2025

The COPII Transport Complex Participates in HPV16 Infection.

Applications

Unspecified application

Species

Unspecified reactive species

Patricia M Day,Cynthia D Thompson,Andrea S Weisberg,John T Schiller
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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