AB32564

Anti-CCR11 antibody [E100]

RabMAb
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(2 제품이 사용된 논문 )

Rabbit Monoclonal CCR11 antibody. Suitable for WB and reacts with Human samples. Cited in 2 publications.

1 이미지

Unknown

Western blot - Anti-CCR11 antibody [E100] (AB32564)

All lanes:

Western blot - Anti-CCR11 antibody [E100] (ab32564) at 1/10000 dilution

All lanes:

K562 cell lysate

Predicted band size: 40 kDa

Observed band size: 45 kDa

false

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

E100

Isotype

IgG

Carrier free

Reacts with

Human

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Specificity

The antibody recognises CKRB/CKR11. It does not cross-react with other G-protein coupled receptor 1 family members.

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHC" : {"fullname" : "Immunohistochemistry", "shortname":"IHC"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHC-species-checked": "notRecommended", "IHC-species-dilution-info": "", "IHC-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/5000 - 1/10000", "WB-species-notes": "" }, "Mouse": { "IHC-species-checked": "notRecommended", "IHC-species-dilution-info": "", "IHC-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHC-species-checked": "notRecommended", "IHC-species-dilution-info": "", "IHC-species-notes": "", "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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제품 세부 정보

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

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특성 및 보관 정보

제형

Liquid

보관 버퍼

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.05% BSA

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CCR11 also known as chemokine (C-C motif) receptor 11 is a member of the large protein family of G protein-coupled receptors (GPCRs). This receptor has a molecular mass of approximately 45 kDa. It is primarily expressed on immune cells such as T cells dendritic cells and macrophages. CCR11 functions mainly by binding to specific chemokines small signaling proteins that guide the movement of circulating leukocytes to sites of inflammation or injury. The expression pattern helps mediate immune responses contributing to its pivotal role in the immune system.

Biological function summary

The movement and positioning of immune cells heavily depend on receptors like CCR11. It couples with chemokines to facilitate leukocyte migration and activation a necessary process during immune surveillance and response to pathogens. While not part of a larger protein complex CCR11 collaborates intimately with other chemokine receptors in orchestrating efficient immune responses. Its role highlights the importance of receptor-mediated chemotaxis in maintaining both innate and adaptive immunity.

Pathways

Chemotaxis and signaling cascades are essential areas where CCR11 participates actively. The receptor is a component of the chemokine signaling pathway interacting closely with other receptors like CCR7 and CCL19/CCL21 chemokines. It aligns with pathways such as those governing inflammation response and cell migration linking with proteins necessary for cellular communication in the immune network. CCR11's functionality within these pathways helps fine-tune immune cell trafficking.

Research identifies CCR11 as key in inflammatory diseases and certain cancers. The receptor's misregulation can contribute to chronic inflammatory conditions or tumor progression by affecting immune cell dynamics. Proteins like CCL5 known to interact with CCR11 have been implicated in these disease contexts aiding in the recruitment of immune cells to tumors. Understanding CCR11's role in such disorders provides insight into potential therapeutic interventions to modulate immune responses.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.

See full target information ACKR4

대체 명칭 보기

CCBP2, CCR11, CCRL1, VSHK1, ACKR4, Atypical chemokine receptor 4, C-C chemokine receptor type 11, CC chemokine receptor-like 1, CCX CKR, C-C CKR-11, CC-CKR-11, CCR-11

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

The EMBO journal 40:e106106 PubMed33709453

2021

Dual targeting of brain region-specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1.

Applications

Unspecified application

Species

Unspecified reactive species

Won-Seok Lee,Laura Lavery,Maxime W C Rousseaux,Eric B Rutledge,Youjin Jang,Ying-Wooi Wan,Sih-Rong Wu,Wonho Kim,Ismael Al-Ramahi,Smruti Rath,Carolyn J Adamski,Vitaliy V Bondar,Ambika Tewari,Shirin Soleimani,Samantha Mota,Hari K Yalamanchili,Harry T Orr,Zhandong Liu,Juan Botas,Huda Y Zoghbi

European urology 61:385-94 PubMed22079021

2011

T lymphocyte recruitment into renal cell carcinoma tissue: a role for chemokine receptors CXCR3, CXCR6, CCR5, and CCR6.

Applications

Unspecified application

Species

Unspecified reactive species

Kimberley A Oldham,Greg Parsonage,Rupesh I Bhatt,D Michael A Wallace,Nayneeta Deshmukh,Shalini Chaudhri,David H Adams,Steven P Lee

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CCR11 antibody [E100]

Western blot - Anti-CCR11 antibody [E100] (AB32564)

관련 conjugated 항체와 다양한 조성의 항체 (1)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

Specificity

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (2)

Product promise