AB110905

Anti-CCT6A antibody

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(5 제품이 사용된 논문 )

Rabbit Polyclonal CCT6A antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 5 publications. Immunogen corresponding to Synthetic Peptide within Human CCT6A.

대체 명칭 보기

CCT6, CCTZ, CCT6A, T-complex protein 1 subunit zeta, TCP-1-zeta, Acute morphine dependence-related protein 2, CCT-zeta-1, Chaperonin containing T-complex polypeptide 1 subunit 6A, HTR3, Tcp20

2 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCT6A antibody (AB110905)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCT6A antibody (AB110905)

ab110905, at a 1/50 dilution, staining CCT6A in paraffin embedded Human breast carcinoma tissue by Immunohistochemistry. The image on the right is from tissue treated with the synthesized peptide.

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Western blot - Anti-CCT6A antibody (AB110905)

All lanes:

Western blot - Anti-CCT6A antibody (ab110905) at 1/500 dilution

Lane 1:

HepG2 cell extracts at 30 µg

Lane 2:

HepG2 cell extracts at 30 µg with immunizing peptide

Predicted band size: 58 kDa

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주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human CCT6A. The exact immunogen used to generate this antibody is proprietary information.

P40227

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

Purification 관련 사항

ab110905 was affinity purified from rabbit antiserum by affinity chromatography using epitope specific immunogen.

보관 버퍼

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride

배송 시 보관 조건

Blue Ice

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

보관 정보

Stable for 12 months at -20°C

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CCT6A also known as TCP-1-zeta or CCT-zeta acts as a component of the chaperonin-containing TCP-1 complex with a mass approximately 60 kDa. This complex facilitates protein folding in an ATP-dependent manner. Predominantly researchers find CCT6A in the cytoplasm of eukaryotic cells and it expresses in various tissues indicating its broad functional role.

Biological function summary

CCT6A plays an important role in folding newly synthesized proteins and refolding denatured proteins. It is a part of the essential chaperonin complex that consists of eight different subunits including CCT6A which collaborates to ensure correct protein conformation. This function supports cellular proteostasis maintaining the balance and health of the proteome which is critical for proper cell function and survival.

Pathways

CCT6A participates in the protein folding pathway and interacts with the protein catabolic processes. It plays an important part in pathways such as cytosolic protein folding and folding of actin and tubulin. Through these pathways CCT6A associates with proteins like HSP70 which also contributes to protein folding and stability signifying shared roles in maintaining cell homeostasis.

CCT6A's involvement impacts various neurodegenerative conditions and cancer. Misfolded proteins that are not adequately managed by chaperonin complexes including CCT6A are linked to diseases like Alzheimer's. In cancer the misregulation of protein folding pathways involving CCT6A might contribute to tumorigenesis. CCT6A holds connections with proteins such as p53 where impaired folding of tumor suppressors can lead to oncogenic outcomes.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed : 25467444, PubMed : 36493755, PubMed : 35449234, PubMed : 37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed : 25467444).

See full target information CCT6A

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제품이 사용된 논문 (5)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Clinical and translational medicine 14:e70097 PubMed39556022

2024

Chaperonin-containing TCP1 subunit 6A inhibition via TRIM21-mediated K48-linked ubiquitination suppresses triple-negative breast cancer progression through the AKT signalling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Mengdi Yang,Jianing Cao,Tiantian Liu,Bin Li,Jinyan Wang,Shuangyue Pan,Duancheng Guo,Zhonghua Tao,Xichun Hu

Oncology letters 25:201 PubMed37113398

2023

CCT6A is associated with CDC20, Enneking stage and prognosis in osteosarcoma, and its knockdown suppresses osteosarcoma cell viability and invasion.

Applications

Unspecified application

Species

Unspecified reactive species

Ning Wang,Yong Chen,Jie Wu

Journal of clinical laboratory analysis 36:e24609 PubMed35838025

2022

The intercorrelation among CCT6A, CDC20, CCNB1, and PLK1 expressions and their clinical value in papillary thyroid carcinoma prognostication.

Applications

IHC

Species

Human

Wei Peng,Wenqiang Li,Xiaoyong Zhang,Weili Cen,Yanan Liu

Molecular medicine reports 25: PubMed35315492

2022

HOXB2 increases the proliferation and invasiveness of colon cancer cells through the upregulation of CCT6A.

Applications

Unspecified application

Species

Unspecified reactive species

Xuelian Yang,Yuanhe Tong,Wenxia Ye,Lifen Chen

Cell death & disease 10:644 PubMed31501420

2019

CCT3 acts upstream of YAP and TFCP2 as a potential target and tumour biomarker in liver cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Ya Liu,Xiao Zhang,Jiafei Lin,Yuxin Chen,Yongxia Qiao,Susu Guo,Yueyue Yang,Guoqing Zhu,Qiuhui Pan,Jiayi Wang,Fenyong Sun

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CCT6A antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CCT6A antibody (AB110905)

Western blot - Anti-CCT6A antibody (AB110905)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (5)

Product promise