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AB201084

Anti-CD101 antibody

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Rabbit Polyclonal CD101 antibody. Suitable for WB and reacts with Human, Mouse, Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human CD101 aa 750-850.

대체 명칭 보기

CD101, EWI101, IGSF2, V7, Immunoglobulin superfamily member 2, IgSF2, Cell surface glycoprotein V7, Glu-Trp-Ile EWI motif-containing protein 101, EWI-101

1 이미지
Western blot - Anti-CD101 antibody (AB201084)
  • WB

Supplier Data

Western blot - Anti-CD101 antibody (AB201084)

All lanes:

Western blot - Anti-CD101 antibody (ab201084)

Lane 1:

HEK293T whole cell lysate

Lane 2:

Mouse Raw 264.7 whole cell lysate

Lane 3:

Rat H9C2 whole cell lysate

Predicted band size: 115 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB

applications

Immunogen

Synthetic Peptide within Human CD101 aa 750-850. The exact immunogen used to generate this antibody is proprietary information.

Q93033

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
ab201084 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
보관 버퍼
pH: 7.3 Preservative: 0.05% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CD101 also known as IGSF2 or V7 is a transmembrane protein that weighs approximately 140 kDa. This protein is part of the immunoglobulin superfamily and is expressed on the surface of certain immune cells including dendritic cells macrophages monocytes and regulatory T cells. Researchers have also detected CD101 on some subsets of B cells. The protein has a significant role in the modulation of immune responses and functions as a marker in immune system studies.
Biological function summary

CD101 influences the immune response through its regulatory effects on cell signaling and interaction. The protein's function often centers within a complex environment contributing to the inhibitory signaling pathways that help balance immune activation. Its presence on regulatory T cells suggests a role in suppressing overactive immune responses which is important to maintaining immune homeostasis. Researchers associate CD101 expression with the control of inflammatory processes highlighting its functional significance.

Pathways

Research shows that CD101 participates in pathways key to immune regulation such as the T-cell receptor signaling pathway. This involvement connects CD101 with proteins like CD3 and CD4 emphasizing its role in modulating T-cell response. The protein plays a part in downstream signaling events that fine-tune immune responses by dampening excessive activation therefore helping prevent autoimmune reactions. It ensures the immune system effectively targets pathogens without harming host tissues.

Studies correlate CD101 expression with autoimmune diseases and inflammatory diseases including inflammatory bowel disease (IBD). These associations suggest a potential protective role of CD101 in managing chronic inflammation. Scientists have also observed interactions with proteins like TNF-alpha in these contexts reflecting the complex interplay CD101 has with pro-inflammatory cytokines. Understanding CD101's involvement in disease processes can aid in developing therapeutic strategies that aim to modulate immune responses effectively.

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

타겟 정보

Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3-induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells.
See full target information CD101

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in pharmacology 13:862085 PubMed35370630

2022

Pterostilbene in Combination With Mitochondrial Cofactors Improve Mitochondrial Function in Cellular Models of Mitochondrial Diseases.

Applications

Unspecified application

Species

Unspecified reactive species

Juan M Suárez-Rivero,Carmen J Pastor-Maldonado,Ana Romero-González,David Gómez-Fernandez,Suleva Povea-Cabello,Mónica Álvarez-Córdoba,Irene Villalón-García,Marta Talaverón-Rey,Alejandra Suárez-Carrillo,Manuel Munuera-Cabeza,José A Sánchez-Alcázar
제품이 사용된 논문 모두 보기

Product promise

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