AB33483

Anti-CD11c antibody [N418]

Name: Anti-CD11c antibody [N418]
Brand: Abcam Limited
SKU: AB33483
Rating: 4 (14 reviews)

(14 리뷰들)

(96 제품이 사용된 논문 )

Armenian hamster Monoclonal CD11c antibody. Suitable for Flow Cyt and reacts with Mouse samples. Cited in 96 publications.

2 이미지

Flow Cytometry - Anti-CD11c antibody [N418] (AB33483)

Flow Cyt

AbReview50886****

Flow Cytometry - Anti-CD11c antibody [N418] (AB33483)

Flow cytometry analysis of murine alveolar cells extracted using bronchoaveolar lavage in balb/c mice using 3mM PBS-EDTA, labelling CD11c with ab33483 at 1/2000, incubated for 20 mins at 20°C. Secondary used was ab175680 at 1/2000. Gating strategy was against CD45+, C11b+, GR1-cells.

Flow Cyt

Lab

Flow Cytometry - Anti-CD11c antibody [N418] (AB33483)

Mouse splenic cells were incubated with anti-CD11c antibody ab33483 at 1/100 dilution for 30 min at 4°C. The secondary antibody used was goat anti-Armenian Hamster (Alexa Fluor® 488) preadsorbed at 1/100 dilution for 30 min at 4°C. The cells were simultaneously stained with CD3 PE-conjugated (ab22268) at 1/200 dilution.

Acquisition of >30,000 total events were collected. Gating strategy – events were collected with the forward and side light-scatter characteristics of viable lymphocytes.

주요 정보

Host species

Armenian hamster

Clonality

Monoclonal

Clone number

N418

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

Flow Cyt

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/100", "FlowCyt-species-notes": "<p><a href='/ko/products/primary-antibodies/armenian-hamster-igg-monoclonal-htk888-isotype-control-ab18479'>ab18479</a> - Armenian Hamster monoclonal IgG, is suitable for use as an isotype control with this antibody.</p>" } } }

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제품 세부 정보

Clone N418 has been reported to enhance antigen specific responses when used to target dendritic cells in vivo.

Want a custom formulation?
This antibody clone is manufactured by Abcam. If you require a custom buffer formulation or conjugation for your experiments, please contact orders@abcam.com

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

보관 버퍼

Preservative: 0.02% Sodium azide Constituents: PBS, 6.97% L-Arginine

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CD11c also known as ITGAX is a subunit of integrin proteins that plays a pivotal role in immune cell function. This protein has a molecular mass of about 150 kDa and is primarily expressed on the surface of dendritic cells monocytes and macrophages. It serves as a marker for these cells commonly utilized in applications like CD11c flow cytometry and CD11c IHC. Researchers often study this target using CD11c antibodies to explore immune system dynamics and cell surface characteristics.

Biological function summary

CD11c functions as an integrin alpha X subunit forming a heterodimer with the beta 2 subunit known as ITGB2. This complex is important for cell adhesion and migration processes. It mediates the binding of leukocytes to endothelial cells facilitating their migration from the bloodstream to sites of inflammation or infection. CD11c's presence on immune cells makes it essential for presenting antigens and initiating immune responses therefore having critical implications for immunity.

Pathways

CD11c plays a significant role in the immune system particularly in the leukocyte adhesion and migration pathways. It partners with proteins like ITGB2 to mediate these functions. The signaling pathways involving CD11c and related molecules regulate leukocyte trafficking and activation ensuring proper localization and function at sites of damage or infection. These pathways are essential for maintaining immune homeostasis and prompt responses to pathogens.

CD11c has significant connections to autoimmune diseases and chronic inflammatory conditions. Aberrant CD11c expression or activity can contribute to the pathogenesis of conditions like rheumatoid arthritis where leukocyte migration and persistent inflammation play a role. Studies also link CD11c with proteins involved in these disorders highlighting its importance in disease progression and potential as a therapeutic target. The understanding of CD11c's role in these conditions can guide the development of treatments aimed at modulating immune responses.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. Functions as a receptor of the erythrocyte-specific adhesion molecule ICAM4 and mediates erythrophagocytosis.

See full target information Itgax

대체 명칭 보기

CD11c, Integrin alpha-X, CD11 antigen-like family member C, Itgax

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제품이 사용된 논문 (96)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Open veterinary journal 15:3558-3570 PubMed41036017

2025

Host-parasite interaction in latent cerebral toxoplasmosis: The role of cytokine response in a mouse model.

Applications

Unspecified application

Species

Unspecified reactive species

Tuğçe Anteplioğlu,Merve Bişkin Türkmen,Erva Eser,Damla Okatan,Oğuz Kul

PloS one 20:e0318107 PubMed39932994

2025

Macrophage-P2X4 receptors pathway is essential to persistent inflammatory muscle hyperalgesia onset, and is prevented by physical exercise.

Applications

Unspecified application

Species

Unspecified reactive species

Graciana de Azambuja,Fernando Moreira Simabuco,Maria Cláudia Gonçalves de Oliveira

Nutrients 16: PubMed39408256

2024

Memory T-Cells Contribute to Calcium Release from Bones during Lactation in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Di Wu,Anna Cline-Smith,Brady Chrisler,Brittani Lubeck,Ajit Perla,Sumona Banerjee,Ida Fan,Rajeev Aurora

Scientific reports 14:21126 PubMed39256539

2024

Maid gene dysfunction promotes hyperobesity via the reduction of adipose tissue inflammation in Mc4r gene-deficient mice.

Applications

Unspecified application

Species

Unspecified reactive species

Kyutaro Koyama,Akira Sakamaki,Shinichi Morita,Itsuo Nagayama,Marina Kudo,Yuto Tanaka,Naruhiro Kimura,Yoshihisa Arao,Hiroyuki Abe,Kenya Kamimura,Shuji Terai

Cell reports. Medicine 5:101528 PubMed38677283

2024

Exogenous non-coding dsDNA-dependent trans-activation of phagocytes augments anti-tumor immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Tiphaine Delaunay,Sehee Son,Seongji Park,Balveen Kaur,Jeonghyun Ahn,Glen N Barber

eLife 12: PubMed38127424

2023

Apoptosis recognition receptors regulate skin tissue repair in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Olivia Justynski,Kate Bridges,Will Krause,Maria Fernanda Forni,Quan M Phan,Teresa Sandoval-Schaefer,Kristyn Carter,Diane E King,Henry C Hsia,Michael I Gazes,Steven D Vyce,Ryan R Driskell,Kathryn Miller-Jensen,Valerie Horsley

Bioactive materials 32:12-27 PubMed37790917

2023

immunomodulation of tumors with biosynthetic bacteria promote anti-tumor immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Zhongda Lin,Fanqiang Meng,Yumeng Ma,Chi Zhang,Zhirang Zhang,Zhaoxin Yang,Yuan Li,Linlin Hou,Yuzhong Xu,Xin Liang,Xudong Zhang

JCI insight 8: PubMed36917181

2023

Thyroid hormone modulates hyperoxic neonatal lung injury and mitochondrial function.

Applications

Unspecified application

Species

Unspecified reactive species

Bianca M Vamesu,Teodora Nicola,Rui Li,Snehashis Hazra,Sadis Matalon,Naftali Kaminski,Namasivayam Ambalavanan,Jegen Kandasamy

Cell reports methods 3:100398 PubMed36936072

2023

Label-free cell segmentation of diverse lymphoid tissues in 2D and 3D.

Applications

Unspecified application

Species

Unspecified reactive species

John W Wills,Jack Robertson,Pani Tourlomousis,Clare M C Gillis,Claire M Barnes,Michelle Miniter,Rachel E Hewitt,Clare E Bryant,Huw D Summers,Jonathan J Powell,Paul Rees

In vivo (Athens, Greece) 37:132-142 PubMed36593019

2023

Age-related Changes in Trigeminal Ganglion Macrophages Enhance Orofacial Ectopic Pain After Inferior Alveolar Nerve Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Shintaro Fujiwara,Kentaro Urata,Tatsuki Oto,Yoshinori Hayashi,Suzuro Hitomi,Koichi Iwata,Toshimitsu Iinuma,Masamichi Shinoda

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CD11c antibody [N418]

Flow Cytometry - Anti-CD11c antibody [N418] (AB33483)

Flow Cytometry - Anti-CD11c antibody [N418] (AB33483)

관련 conjugated 항체와 다양한 조성의 항체 (12)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (96)

Product promise