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AB244721

Anti-CD134 / OX40L receptor antibody [EPR20208-98] - BSA and Azide free (Capture)

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Rabbit Recombinant Monoclonal CD134 / OX40L receptor antibody. Carrier free. Suitable for sELISA and reacts with Human samples.
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Sandwich ELISA - Anti-CD134 / OX40L receptor antibody [EPR20208-98] - BSA and Azide free (Capture) (AB244721)
  • sELISA

Supplier Data

Sandwich ELISA - Anti-CD134 / OX40L receptor antibody [EPR20208-98] - BSA and Azide free (Capture) (AB244721)

Representative standard curve from corresponding SimpleStep ELISA® Kit (ab231926).

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR20208-98

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

sELISA

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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보완 제품

Assay Kits

AB231926

Human OX40 ELISA Kit (TNFRSF4)

Recombinant|SimpleStep

Sandwich ELISA - Human OX40 ELISA Kit (TNFRSF4) (AB231926)

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Sample Prep & Detection Kits

AB201805

DyLight® 755 Conjugation Kit (Fast) - Lightning-Link®

Schematic Diagram - DyLight® 755 Conjugation Kit (Fast) - Lightning-Link® (AB201805)

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Sample Prep & Detection Kits

AB270709

5’ Feature Barcode Antibody Conjugation Kit - Lightning-Link® - Oligos 21-30

Schematic Diagram - 5’ Feature Barcode Antibody Conjugation Kit - Lightning-Link® - Oligos 21-30 (AB270709)

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Primary Antibodies

AB314791

Anti-CD36 antibody [EPR26635-8] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-CD36 antibody [EPR26635-8] - BSA and Azide free (Capture) (AB314791)

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Primary Antibodies

AB245029

Anti-GITR antibody [EPR20427-30] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-GITR antibody [EPR20427-30] - BSA and Azide free (Detector) (AB245029)

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Primary Antibodies

AB245058

Anti-CD30 antibody [EPR21828-217] - BSA and Azide free (Detector)

RabMAb|Recombinant

Sandwich ELISA - Anti-CD30 antibody [EPR21828-217] - BSA and Azide free (Detector) (AB245058)

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Primary Antibodies

AB242514

Anti-Soluble TNF Receptor I antibody [EPR18822-47] - BSA and Azide free (Capture)

RabMAb|Recombinant

Sandwich ELISA - Anti-Soluble TNF Receptor I antibody [EPR18822-47] - BSA and Azide free (Capture) (AB242514)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "sELISA" : {"fullname" : "Sandwich ELISA", "shortname":"sELISA"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "sELISA-species-checked": "guaranteed", "sELISA-species-dilution-info": "", "sELISA-species-notes": "<p></p>" } } }
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제품 세부 정보

ab244721 is a BSA and Azide Free antibody supplied in an unconjugated format and it is suitable for sandwich ELISAs to quantify Human OX40. The recommended pair for sandwich ELISA is:
Capture: ab244721, Human OX40 Capture Antibody (unconjugated)
Detector: ab244988, Human OX40 Detector Antibody (unconjugated)
The reference range value is 46.9 - 3000 pg/ml.

Patented technology
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

  • - High batch-to-batch consistency and reproducibility
  • - Improved sensitivity and specificity
  • - Long-term security of supply
  • - Animal-free batch production

For more information, read more on recombinant antibodies.

Conjugation ready
Our carrier-free antibodies are typically supplied in a PBS-only formulation, purified and free of BSA, sodium azide and glycerol. This conjugation-ready format is designed for use with fluorochromes, metal isotopes, oligonucleotides, and enzymes, which makes them ideal for antibody labelling, functional and cell-based assays, flow-based assays (e.g. mass cytometry) and Multiplex Imaging applications.

Use our conjugation kits for antibody conjugates that are ready-to-use in as little as 20 minutes with 1 minute hands-on-time and 100% antibody recovery: available for fluorescent dyes, HRP, biotin and gold.

Sandwich ELISA
The recommended antibody orientation is based on internal optimization for ELISA-based assays. Antibody orientation is assay dependent and needs to be optimized for each assay type. Please note that the range provided for this antibody is only an estimation based on the performance of the product using the recommended antibody pair. Performance of the antibody pair will depend on the specific characteristics of your assay. We guarantee the product works in sandwich ELISA, but we do not guarantee the sensitivity or dynamic range of the antibody in your assay.

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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
보관 버퍼
Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
+4°C
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CD134 also known as OX40 or TNFRSF4 is a receptor that plays an essential role in immune response regulation. This receptor is part of the tumor necrosis factor receptor (TNFR) superfamily and has a molecular mass of approximately 50 kDa. CD134 is expressed on activated T cells particularly CD4+ T cells and is present on various other immune cells under specific conditions. The receptor binds to the OX40L its ligand which is expressed on antigen-presenting cells such as dendritic cells and B cells.
Biological function summary

CD134 influences T cell proliferation survival and memory formation being an important component of the immune system's adaptive response. OX40L engagement with CD134 enhances the activation and survival of T cells promoting long-term immunity. This interaction does not form part of a larger complex but functions as a direct signaling mechanism that augments T cell receptor (TCR) signaling leading to increased cytokine production and sustained immune responses essential for controlling infections and cancer.

Pathways

CD134 signaling intersects with the nuclear factor-kappa B (NF-κB) and phosphoinositide 3-kinase (PI3K) pathways. These pathways play significant roles in regulating immune responses and cell survival. Through the NF-κB pathway CD134 influences gene transcription related to immune activation. It also connects with other immune regulatory proteins such as CD28 which further potentiates T cell responses and enhances effector functions.

CD134 has connections to autoimmune diseases and cancers. Overactivity of the CD134-OX40L pathway can lead to exacerbated autoimmune conditions such as lupus. This receptor has also been implicated in tumor immunity where its activation enhances the anti-tumor response of T cells. CD134 interacts with CTLA-4 another immune checkpoint protein playing a role in balancing immune activation and regulation within these disease contexts.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.. (Microbial infection) Acts as a receptor for human herpesvirus 6B/HHV-6B.
See full target information TNFRSF4

대체 명칭 보기

CD134, TXGP1L, TNFRSF4, Tumor necrosis factor receptor superfamily member 4, ACT35 antigen, OX40L receptor, TAX transcriptionally-activated glycoprotein 1 receptor
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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