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AB231049

Anti-CD14 antibody

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Rabbit Polyclonal CD14 antibody. Suitable for WB, IHC-P and reacts with Pig samples. Cited in 1 publication.

대체 명칭 보기

CD14 antigen, CD14 molecule, CD14_HUMAN, CD_antigen=CD14, LPS-R, Mo2, Monocyte differentiation antigen CD14, Monocyte differentiation antigen CD14 urinary form, Monocyte differentiation antigen CD14, membrane-bound form, Myeloid cell-specific leucine-rich glycoprotein

4 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD14 antibody (AB231049)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD14 antibody (AB231049)

Formalin-fixed, paraffin-embedded pig liver tissue stained for CD14 with ab231049 at 20 μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-CD14 antibody (AB231049)
  • WB

Unknown

Western blot - Anti-CD14 antibody (AB231049)

All lanes:

Western blot - Anti-CD14 antibody (ab231049) at 2 µg/mL

All lanes:

Pig lymph node

Predicted band size: 40 kDa,60 kDa

false

Western blot - Anti-CD14 antibody (AB231049)
  • WB

Supplier Data

Western blot - Anti-CD14 antibody (AB231049)

All lanes:

Western blot - Anti-CD14 antibody (ab231049) at 2 µg/mL

All lanes:

Recombinant pig CD14 protein

Predicted band size: 40 kDa

true

Western blot - Anti-CD14 antibody (AB231049)
  • WB

Unknown

Western blot - Anti-CD14 antibody (AB231049)

All lanes:

Western blot - Anti-CD14 antibody (ab231049) at 2 µg/mL

All lanes:

Pig skin

Predicted band size: 40 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Pig

Applications

IHC-P, WB

applications

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대체품

Primary Antibodies

AB183322

Anti-CD14 antibody [SP192]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD14 antibody [SP192] (AB183322)

  • 5
  • 5
Primary Antibodies

AB133503

Anti-CD14 antibody [EPR3652]

20ul selling size|RabMAb|Recombinant

Flow Cytometry - Anti-CD14 antibody [EPR3652] (AB133503)

  • 0
  • 0
Primary Antibodies

AB214438

Anti-CD14 antibody [EPR3653] - Low endotoxin, Azide free

BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD14 antibody [EPR3653] - Low endotoxin, Azide free (AB214438)

  • 3
  • 1
Primary Antibodies

AB209971

Anti-CD14 antibody [EPR3652] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry - Anti-CD14 antibody [EPR3652] - BSA and Azide free (AB209971)

  • 0
  • 0
Primary Antibodies

AB133335

Anti-CD14 antibody [EPR3653]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD14 antibody [EPR3653] (AB133335)

  • 4
  • 1
Primary Antibodies

AB221678

Anti-CD14 antibody [EPR21847]

20ul selling size|RabMAb|Recombinant

Flow Cytometry - Anti-CD14 antibody [EPR21847] (AB221678)

  • 5
  • 1
Primary Antibodies

AB231852

Anti-CD14 antibody [EPR21847] - BSA and Azide free

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-CD14 antibody [EPR21847] - BSA and Azide free (AB231852)

  • 0
  • 0

보완 제품

Primary Antibodies

AB310335

Anti-Neutrophil Elastase antibody [EPR28386-66]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|Advanced Validation

Multiplex immunohistochemistry - Anti-Neutrophil Elastase antibody [EPR28386-66] (AB310335)

  • 0
  • 0
Primary Antibodies

AB134147

Anti-CD79b antibody [EPR6861]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunocytochemistry/ Immunofluorescence - Anti-CD79b antibody [EPR6861] (AB134147)

  • 2
  • 1
Primary Antibodies

AB53025

Anti-ENO1 + ENO2 + ENO3 antibody

Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ENO1 + ENO2 + ENO3 antibody (AB53025)

  • 4
  • 11
Primary Antibodies

AB134114

Anti-CD19 antibody [EPR5906]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Flow Cytometry (Intracellular) - Anti-CD19 antibody [EPR5906] (AB134114)

  • 4
  • 5
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.5-2 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 µg/mL", "IHCP-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
Antigen-specific affinity chromatography followed by Protein A affinity chromatography
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CD14 also known as cluster of differentiation 14 is a glycoprotein with a molecular mass of approximately 55 kDa. This protein is expressed mainly on the surface of macrophages monocytes and to a lesser extent on neutrophils. CD14 exists in two forms: membrane-bound (mCD14) and soluble (sCD14). It functions as a co-receptor along with TLR4 (Toll-like receptor 4) and MD-2 for the detection of bacterial lipopolysaccharide (LPS) which is an important component of the outer membrane of Gram-negative bacteria.
Biological function summary

This glycoprotein plays a significant role in the innate immune system by recognizing pathogen-associated molecular patterns (PAMPs). It is part of a receptor complex where CD14 acts alongside LPS binding protein (LPS-R) TLR4 and MD-2 to facilitate pro-inflammatory signaling in response to microbial invasion. By binding to LPS CD14 initiates and amplifies the immune response leading to the production of cytokines and the recruitment of other immune cells to the site of infection.

Pathways

CD14 interacts with the toll-like receptor signaling pathway notably involving TLR4. Upon LPS detection CD14 assists in the activation of TLR4 triggering downstream signaling cascades such as NF-κB and MAPK pathways. These pathways result in the transcription of inflammatory cytokines and are essential for the host defense mechanism. The protein complex involving CD14 further interacts with adaptor proteins like MyD88 and TRIF facilitating signal propagation and the immune system's ability to respond to pathogens.

Researchers have linked CD14 to sepsis and atherosclerosis. High levels of soluble CD14 (sCD14) are often observed in patients with sepsis indicating its participation in excessive systemic inflammation. In atherosclerosis CD14's role in recognizing LPS contributes to chronic inflammation and the development of plaques in arteries. Through these diseases CD14 connects with TLR4 emphasizing its impact on inflammatory responses and its potential as a therapeutic target.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

See full target information CD14
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

NPJ Regenerative medicine 9:37 PubMed39639015

2024

Attenuation of skin injury by a MARCO targeting PLGA nanoparticle.

Applications

Unspecified application

Species

Unspecified reactive species

Ummiye V Onay,Dan Xu,Dauren Biyashev,Spencer T Evans,Michael M Demczuk,Tobias Neef,Joseph R Podojil,Sara Beddow,Nathan C Gianneschi,I Caroline Le Poole,Stephen D Miller,Kurt Q Lu
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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