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AB253264

Anti-CD167a/DDR1 antibody [51D6]

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(1 출판물)

Mouse Monoclonal CD167a/DDR1 antibody. Suitable for Flow Cyt and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing DDR1 protein.

대체 명칭 보기

CD167a, CAK, EDDR1, NEP, NTRK4, PTK3A, RTK6, TRKE, DDR1, Epithelial discoidin domain-containing receptor 1, Epithelial discoidin domain receptor 1, CD167 antigen-like family member A, Cell adhesion kinase, Discoidin receptor tyrosine kinase, HGK2, Mammary carcinoma kinase 10, Protein-tyrosine kinase 3A, Protein-tyrosine kinase RTK-6, TRK E, Tyrosine kinase DDR, Tyrosine-protein kinase CAK, MCK-10

1 이미지
Flow Cytometry - Anti-CD167a/DDR1 antibody [51D6] (AB253264)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-CD167a/DDR1 antibody [51D6] (AB253264)

Flow Cytometry analysis of MCF7 (human breast adenocarcinoma cell line) cells labeling CD167a/DDR1 with ab253264 at 5 μg/mL. Surface staining.

관련 conjugated 항체와 다양한 조성의 항체 (1)

  • 578 PE

    PE Anti-CD167a/DDR1 antibody [51D6]

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

51D6

Isotype

IgM

Carrier free

No

Reacts with

Human

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing DDR1 protein. The exact immunogen used to generate this antibody is proprietary information.

Q08345

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대체품

Primary Antibodies

AB255810

Anti-CD167a/DDR1 antibody [EPR22316-508]

RabMAb|Recombinant

Flow Cytometry - Anti-CD167a/DDR1 antibody [EPR22316-508] (AB255810)

  • 0
  • 0
Primary Antibodies

AB261728

Anti-CD167a/DDR1 antibody [EPR22316-508] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry - Anti-CD167a/DDR1 antibody [EPR22316-508] - BSA and Azide free (AB261728)

  • 0
  • 0

보완 제품

Assay Kits

AB260063

Human CD167a/DDR1 ELISA Kit

Recombinant|SimpleStep

ELISA - Human CD167a/DDR1 ELISA Kit (AB260063)

  • 0
  • 0
Primary Antibodies

AB316249

Anti-ITGA11 antibody [EPR28689-21]

BOND RX™ Validated|20ul selling size|Recombinant|RabMAb|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ITGA11 antibody [EPR28689-21] (AB316249)

  • 0
  • 0
Assay Kits

AB267687

Human CD167a/DDR1 Antibody Pair - BSA and Azide free

RabMAb|Recombinant

Sandwich ELISA - Human CD167a/DDR1 Antibody Pair - BSA and Azide free (AB267687)

  • 0
  • 0
Primary Antibodies

AB51074

Anti-MMP14 antibody [EP1264Y]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Western blot - Anti-MMP14 antibody [EP1264Y] (AB51074)

  • 4
  • 20
Proteins & Peptides

AB101591

Recombinant human CD167a/DDR1 protein (GST tag N-Terminus)

Functional Studies - Recombinant human CD167a/DDR1 protein (AB101591)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "5 µg/mL", "FlowCyt-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 관련 사항
Precipitation and chromatography. Greater than 95% pure by SDS-PAGE.
보관 버퍼
pH: 8 Preservative: 0.0975% Sodium azide Constituents: Tris buffered saline
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CD167a also known as DDR1 (Discoidin Domain Receptor 1) is a receptor tyrosine kinase with a molecular mass of approximately 101 kDa. This protein is expressed widely in various tissues including the thyroid lung kidney and mammary gland. It becomes activated upon collagen binding leading to the regulation of cell adhesion proliferation and extracellular matrix remodeling. The DDR1 protein plays a mechanistic role in responding to unique collagen-rich environments within the body.
Biological function summary

CD167a/DDR1 modulates interactions between cells and their surrounding matrix. It is involved in a complex with collagen mediating signal transduction processes. This interaction is important for cellular biophysical responses driving processes like cell migration and differentiation. In marmoset thyroid tissue DDR1 helps maintain structural integrity and regulates cellular activities important for normal thyroid function.

Pathways

CD167a/DDR1 participates in key signaling pathways including those related to cell adhesion and extracellular matrix remodeling. Specifically it operates within the MAPK/ERK pathway influencing cell cycle dynamics and responses to stress signals. DDR1 also interacts with proteins like SHC and Ras enabling communication between the cell surface and intracellular targets necessary for growth and adaptation.

Mutations or irregular expression of CD167a/DDR1 have implications in cancer and fibrotic diseases. Overexpression or aberration of DDR1 can contribute to tumorigenesis facilitating tumor cell invasion and metastasis. In fibrotic conditions altered DDR1 activity can disrupt normal matrix remodeling linking it to proteins such as collagen I and III which play major roles in these disorders. Understanding DDR1's role offers potential for therapeutic interventions in targeting related pathological conditions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.
See full target information DDR1
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Bioengineered 13:10827-10842 PubMed35470736

2022

Colorectal cancer stem cell-derived exosomal long intergenic noncoding RNA 01315 (LINC01315) promotes proliferation, migration, and stemness of colorectal cancer cells.

Applications

Unspecified application

Species

Unspecified reactive species

Youran Li,Minna Wu,Shanshan Xu,Hua Huang,Lei Yan,Yunfei Gu
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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