AB33734

Anti-CD200 / OX2 antibody [MRC OX90]

Name: Anti-CD200 / OX2 antibody [MRC OX90]
Brand: Abcam Limited
SKU: AB33734
Rating: 4 (1 reviews)

(1 리뷰)

(4 제품이 사용된 논문 )

Rat Monoclonal CD200 / OX2 antibody. Suitable for IHC-FoFr and reacts with Mouse samples. Cited in 4 publications. Immunogen corresponding to Recombinant Protein within Mouse Cd200.

1 이미지

Immunohistochemistry (PFA perfusion fixed frozen sections) - Anti-CD200 / OX2 antibody [MRC OX90] (AB33734)

IHC-FoFr

AbReview32638****

Immunohistochemistry (PFA perfusion fixed frozen sections) - Anti-CD200 / OX2 antibody [MRC OX90] (AB33734)

Immunohistochemical analysis of murine brain tissue, staining CD200 / OX2 with ab33734.

Tissue was fixed with paraformaldehyde and blocked with 5% BSA + 5% serum for 1 hour at room temperature. Samples were incubated with primary antibody (1/600 in 5% BSA + 5% NGS) for 17 hours at 4°C. An AlexaFluor®555-conjugated goat anti-rat polyclonal IgG (1/200) was used as the secondary antibody.

This image is courtesy of an anonymous Abreview

주요 정보

Host species

Rat

Clonality

Monoclonal

Clone number

MRC OX90

Isotype

IgG2a

Carrier free

Reacts with

Mouse

Applications

IHC-FoFr

applications

Immunogen

Recombinant Protein within Mouse Cd200. The exact immunogen used to generate this antibody is proprietary information.

O54901

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCFoFr" : {"fullname" : "Immunohistochemistry (PFA perfusion fixed frozen sections)", "shortname":"IHC-FoFr"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "IHCFoFr-species-checked": "testedAndGuaranteed", "IHCFoFr-species-dilution-info": "", "IHCFoFr-species-notes": "<p></p>" } } }

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제품 세부 정보

Spleen cells from immunised rats were fused with cells of the rat Y3 myeloma cell line.

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

This purified antibody was prepared by affinity chromatography on Protein G from tissue culture supernatant.

보관 버퍼

Preservative: 0.09% Sodium azide Constituents: PBS

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CD200 also known as OX2 is a cell surface glycoprotein with a molecular mass of approximately 43 kDa. It plays a mechanical role in immune response regulation. CD200 expression occurs on several cell types such as thymocytes neurons vascular endothelium and splenocytes including cynomolgus monkey splenocytes. This protein generally modulates interactions between cells sending inhibitory signals through its receptor CD200R found on myeloid cells and certain lymphoid cells.

Biological function summary

CD200 regulates the immune system by inhibiting inflammatory responses and maintaining immune homeostasis. It does not act as part of a significant multi-protein complex but directly interacts with CD200R. This interaction promotes an anti-inflammatory state and is important in preventing autoimmune diseases and excessive tissue damage. The expression of CD200 is also an indicator of immune tolerance in various tissues.

Pathways

CD200 is involved in immune regulatory pathways. It plays a pivotal role in the suppression of immune responses through the CD200-CD200R signaling pathway. This pathway is vital for dampening inflammatory processes related to autoimmune reactions and is consequently linked to the maintenance of tissue homeostasis. Proteins related to CD200 through these pathways include CD200R and other molecules involved in immune checkpoint pathways.

CD200 expression correlates with several conditions including cancer and autoimmune diseases. The overexpression of CD200 in certain tumors promotes immune evasion thereby favoring tumor progression. Conversely reduced CD200 levels are associated with autoimmune disorders where a hyperactive immune system attacks self-tissues. Through these disease contexts CD200 operates alongside proteins such as CD200R and OX90 impacting disease progression and immune system modulation.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues (By similarity).

See full target information Cd200

대체 명칭 보기

CD200, Mox2, Cd200, OX-2 membrane glycoprotein, MRC OX-2 antigen

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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature biomedical engineering 8:1285-1307 PubMed39085645

2024

Prevention and treatment of peri-implant fibrosis by functionally inhibiting skeletal cells expressing the leptin receptor.

Applications

Unspecified application

Species

Unspecified reactive species

Vincentius Jeremy Suhardi,Anastasia Oktarina,Mohammed Hammad,Yingzhen Niu,Qingdian Li,Andrew Thomson,Juan Lopez,Jason McCormick,Ugur M Ayturk,Matthew B Greenblatt,Lionel B Ivashkiv,Mathias P G Bostrom,Xu Yang

Brain and behavior 10:e01882 PubMed33067924

2020

CD200-CD200R1 signaling pathway regulates neuroinflammation after stroke.

Applications

Unspecified application

Species

Unspecified reactive species

Shou-Cai Zhao,Xu Heng,Wang Ya-Ping,Luan Di,Wu Wen-Qian,Ma Ling-Song,Zhao-Hu Chu,Yang Xu

Nature 562:133-139 PubMed30250253

2018

Discovery of a periosteal stem cell mediating intramembranous bone formation.

Applications

Unspecified application

Species

Unspecified reactive species

Shawon Debnath,Alisha R Yallowitz,Jason McCormick,Sarfaraz Lalani,Tuo Zhang,Ren Xu,Na Li,Yifang Liu,Yeon Suk Yang,Mark Eiseman,Jae-Hyuck Shim,Meera Hameed,John H Healey,Mathias P Bostrom,Dan Avi Landau,Matthew B Greenblatt

Brain, behavior, and immunity 26:778-88 PubMed21986303

2011

Age-related changes in the hippocampus (loss of synaptophysin and glial-synaptic interaction) are modified by systemic treatment with an NCAM-derived peptide, FGL.

Applications

Unspecified application

Species

Unspecified reactive species

Bunmi Ojo,Payam Rezaie,Paul L Gabbott,Heather Davies,Frances Colyer,Thelma R Cowley,Marina Lynch,Michael G Stewart

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CD200 / OX2 antibody [MRC OX90]

Immunohistochemistry (PFA perfusion fixed frozen sections) - Anti-CD200 / OX2 antibody [MRC OX90] (AB33734)

관련 conjugated 항체와 다양한 조성의 항체 (3)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

보완 제품

Assay Kits

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (4)

Product promise