JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB199140

Anti-CD24 antibody

Be the first to review this product! 리뷰 제출

|

(6 제품이 사용된 논문 )

Rabbit Polyclonal CD24 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Synthetic Peptide within Human CD24.

대체 명칭 보기

CD24, CD24A, Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD24 antibody (AB199140)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD24 antibody (AB199140)

Immunohistochemical analysis of paraffin-embedded Human thyroid cancer tissue labeling CD24 with ab199140 at 1/40 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD24 antibody (AB199140)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD24 antibody (AB199140)

Immunohistochemical analysis of paraffin-embedded Human colon cancer tissue labeling CD24 with ab199140 at 1/40 dilution.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human CD24. The exact immunogen used to generate this antibody is proprietary information.

P25063

style
left-column

대체품

Primary Antibodies

AB30350

FITC Anti-CD24 antibody [SN3]

Flow Cytometry - FITC Anti-CD24 antibody [SN3] (AB30350)

  • 5
  • 1
Primary Antibodies

AB134375

Anti-CD24 antibody [SN3]

Flow Cytometry - Anti-CD24 antibody [SN3] (AB134375)

  • 5
  • 1
Primary Antibodies

AB179821

Anti-CD24 antibody [EPR3006(N)]

20ul selling size|RabMAb|Recombinant

Immunoprecipitation - Anti-CD24 antibody [EPR3006(N)] (AB179821)

  • 0
  • 0
Primary Antibodies

AB228455

Anti-CD24 antibody [EPR19925] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry - Anti-CD24 antibody [EPR19925] - BSA and Azide free (AB228455)

  • 1
  • 1
Primary Antibodies

AB202073

Anti-CD24 antibody [EPR19925]

RabMAb|Recombinant|20ul selling size

Flow Cytometry - Anti-CD24 antibody [EPR19925] (AB202073)

  • 4
  • 3

보완 제품

Primary Antibodies

AB133616

Anti-CD4 antibody [EPR6855]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD4 antibody [EPR6855] (AB133616)

  • 5
  • 20
Primary Antibodies

AB189524

Anti-CD44 antibody [EPR18668]

RabMAb|Recombinant|Lab Essentials|20ul selling size|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD44 antibody [EPR18668] (AB189524)

  • 5
  • 1
Primary Antibodies

AB19898

Anti-CD133 antibody - Stem Cell Marker

Lab Essentials

Western blot - Anti-CD133 antibody - Stem Cell Marker (AB19898)

  • 4
  • 27
Primary Antibodies

AB137132

Anti-PD1 antibody [EPR4877(2)]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-PD1 antibody [EPR4877(2)] (AB137132)

  • 5
  • 5
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p>" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CD24 also known as heat-stable antigen or CD24A is a glycosylphosphatidylinositol (GPI)-anchored membrane protein with a molecular mass of approximately 30-50 kDa. It is expressed on the surface of many cell types including B cells T cells neutrophils and epithelial cells. CD24 plays a role in cell adhesion and signaling processes impacting immune response and cancer progression. Its expression is often used as a marker in identification and classification procedures such as flow cytometry.
Biological function summary

CD24 functions like a molecular "switch" modulating signals sent between cells. It acts as a ligand for multiple receptors and participates in cellular communication especially influencing the immune system. Part of its biological role involves interaction within cellular complexes impacting immune modulation and inflammatory responses. CD24's location at the interface of cellular microenvironments makes it critical for cellular response adaptation to varied external stimuli.

Pathways

CD24 participates in both immune signaling and cancer-related pathways. It plays a significant role in the suppression of the immune response often interacting with proteins like Siglec-10 in these pathways. CD24's involvement in these pathways contributes to cell survival and proliferation particularly within cancer development. The protein’s interaction within specified signaling pathways allows it to influence downstream targets that regulate gene expression and cellular functions.

CD24 has significant connections to cancer and inflammatory diseases. It is highly expressed in various cancers including breast and prostate cancer where it correlates with poor prognosis due to its role in apoptosis evasion and metastasis. CD24 interacts with proteins like HMGB1 and is implicated in inflammatory conditions where it modulates immune cell activity. Extensive research into CD24's involvement in these disorders may lead to targeted therapies including the development of anti-CD24 antibodies for therapeutic interventions.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed : 11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).
See full target information CD24
style
left-column

제품이 사용된 논문 (6)

Recent publications for all applications. Explore the 전체 목록 and refine your search

JOR spine 7:e70029 PubMed39717383

2024

CD24 Positive Nucleus Pulposus Cells in Adult Human Intervertebral Discs Maintain a More Notochordal Phenotype Than GD2 Positive Cells.

Applications

Unspecified application

Species

Unspecified reactive species

Andra-Maria Ionescu,Pauline Baird,Sonal Patel,Gareth Howell,Judith A Hoyland,Stephen M Richardson

Cell death & disease 14:350 PubMed37280198

2023

The ufmylation modification of ribosomal protein L10 in the development of pancreatic adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Kun Wang,Siyu Chen,Yue Wu,Yang Wang,Yousheng Lu,Yanzi Sun,Yijun Chen

Cold Spring Harbor molecular case studies 7: PubMed34362827

2021

Metastatic pediatric sclerosing epithelioid fibrosarcoma.

Applications

Unspecified application

Species

Unspecified reactive species

Andrew D Woods,Reshma Purohit,Laura Crocker Mitchell,John R Collier,Katherine A Collier,Melvin Lathara,Katrina Learned,Olena Vaske,Heather Geiger,Kazimierz O Wrzeszczynski,Vaidehi Jobanputra,Ganapati Srinivasa,Erin R Rudzinski,Kimberly Whelan,Elizabeth Beierle,Sheri L Spunt,Charles Keller,Aman Wadhwa

Carcinogenesis 42:190-201 PubMed33313663

2020

SNAIL regulates gastric carcinogenesis through CCN3 and NEFL.

Applications

Unspecified application

Species

Unspecified reactive species

Ru Chen,Kenji Masuo,Akitada Yogo,Shoko Yokoyama,Aiko Sugiyama,Hiroshi Seno,Akihiko Yoshizawa,Shigeo Takaishi

EBioMedicine 56:102783 PubMed32454402

2020

CD24-targeted intraoperative fluorescence image-guided surgery leads to improved cytoreduction of ovarian cancer in a preclinical orthotopic surgical model.

Applications

Unspecified application

Species

Unspecified reactive species

Katrin Kleinmanns,Vibeke Fosse,Ben Davidson,Elvira García de Jalón,Olav Tenstad,Line Bjørge,Emmet McCormack

Journal of biological engineering 12:35 PubMed30598696

2018

CD24 identifies nucleus pulposus progenitors/notochordal cells for disc regeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Zhuochao Liu,Zhiyong Zheng,Jin Qi,Jun Wang,Qi Zhou,Fangqiong Hu,Jing Liang,Changwei Li,Weibin Zhang,Xingkai Zhang
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com