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AB244478

Anti-CD24 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal CD24 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CD24 aa 1-100.

대체 명칭 보기

CD24, CD24A, Signal transducer CD24, Small cell lung carcinoma cluster 4 antigen

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-CD24 antibody (AB244478)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-CD24 antibody (AB244478)

PFA-fixed, Triton X-100 permeabilized RT4 (human urinary bladder cancer cell line) cells stained for CD24 (green) using ab244478 at 4 μg/ml in ICC/IF.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human CD24 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

P25063

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대체품

Primary Antibodies

AB30350

FITC Anti-CD24 antibody [SN3]

Flow Cytometry - FITC Anti-CD24 antibody [SN3] (AB30350)

  • 5
  • 1
Primary Antibodies

AB134375

Anti-CD24 antibody [SN3]

Flow Cytometry - Anti-CD24 antibody [SN3] (AB134375)

  • 5
  • 1
Primary Antibodies

AB179821

Anti-CD24 antibody [EPR3006(N)]

20ul selling size|RabMAb|Recombinant

Immunoprecipitation - Anti-CD24 antibody [EPR3006(N)] (AB179821)

  • 0
  • 0
Primary Antibodies

AB228455

Anti-CD24 antibody [EPR19925] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry - Anti-CD24 antibody [EPR19925] - BSA and Azide free (AB228455)

  • 1
  • 1
Primary Antibodies

AB202073

Anti-CD24 antibody [EPR19925]

RabMAb|Recombinant|20ul selling size

Flow Cytometry - Anti-CD24 antibody [EPR19925] (AB202073)

  • 4
  • 3

보완 제품

Primary Antibodies

AB19898

Anti-CD133 antibody - Stem Cell Marker

Lab Essentials

Western blot - Anti-CD133 antibody - Stem Cell Marker (AB19898)

  • 4
  • 27
Primary Antibodies

AB24982

Cy5 ® Anti-CD45.1 antibody [A20]

  • 0
  • 0
Primary Antibodies

AB16667

Anti-Ki67 antibody [SP6]

BOND RX™ Validated|KO Validated|RabMAb|Advanced Validation|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody [SP6] (AB16667)

  • 5
  • 133
Primary Antibodies

AB115777

Anti-beta Actin antibody [SP124] - Cytoskeleton Marker

20ul selling size|RabMAb|Lab Essentials|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-beta Actin antibody [SP124] - Cytoskeleton Marker (AB115777)

  • 4
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CD24 also known as heat-stable antigen or CD24A is a glycosylphosphatidylinositol (GPI)-anchored membrane protein with a molecular mass of approximately 30-50 kDa. It is expressed on the surface of many cell types including B cells T cells neutrophils and epithelial cells. CD24 plays a role in cell adhesion and signaling processes impacting immune response and cancer progression. Its expression is often used as a marker in identification and classification procedures such as flow cytometry.
Biological function summary

CD24 functions like a molecular "switch" modulating signals sent between cells. It acts as a ligand for multiple receptors and participates in cellular communication especially influencing the immune system. Part of its biological role involves interaction within cellular complexes impacting immune modulation and inflammatory responses. CD24's location at the interface of cellular microenvironments makes it critical for cellular response adaptation to varied external stimuli.

Pathways

CD24 participates in both immune signaling and cancer-related pathways. It plays a significant role in the suppression of the immune response often interacting with proteins like Siglec-10 in these pathways. CD24's involvement in these pathways contributes to cell survival and proliferation particularly within cancer development. The protein’s interaction within specified signaling pathways allows it to influence downstream targets that regulate gene expression and cellular functions.

CD24 has significant connections to cancer and inflammatory diseases. It is highly expressed in various cancers including breast and prostate cancer where it correlates with poor prognosis due to its role in apoptosis evasion and metastasis. CD24 interacts with proteins like HMGB1 and is implicated in inflammatory conditions where it modulates immune cell activity. Extensive research into CD24's involvement in these disorders may lead to targeted therapies including the development of anti-CD24 antibodies for therapeutic interventions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

May have a pivotal role in cell differentiation of different cell types. Signaling could be triggered by the binding of a lectin-like ligand to the CD24 carbohydrates, and transduced by the release of second messengers derived from the GPI-anchor. Modulates B-cell activation responses. Promotes AG-dependent proliferation of B-cells, and prevents their terminal differentiation into antibody-forming cells (PubMed : 11313396). In association with SIGLEC10 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1, HSP70 and HSP90. Plays a role in the control of autoimmunity (By similarity).
See full target information CD24
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature communications 14:5029 PubMed37596273

2023

Spatial transcriptomics reveals distinct and conserved tumor core and edge architectures that predict survival and targeted therapy response.

Applications

Unspecified application

Species

Unspecified reactive species

Rohit Arora,Christian Cao,Mehul Kumar,Sarthak Sinha,Ayan Chanda,Reid McNeil,Divya Samuel,Rahul K Arora,T Wayne Matthews,Shamir Chandarana,Robert Hart,Joseph C Dort,Jeff Biernaskie,Paola Neri,Martin D Hyrcza,Pinaki Bose

Journal of experimental & clinical cancer research : CR 42:5 PubMed36600258

2023

KLF14 regulates the growth of hepatocellular carcinoma cells via its modulation of iron homeostasis through the repression of iron-responsive element-binding protein 2.

Applications

Unspecified application

Species

Unspecified reactive species

Hui Zhou,Junru Chen,Mingjie Fan,Huajian Cai,Yufei Dong,Yue Qiu,Qianqian Zhuang,Zhaoying Lei,Mengyao Li,Xue Ding,Peng Yan,Aifu Lin,Shusen Zheng,Qingfeng Yan
제품이 사용된 논문 모두 보기
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Product promise

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