AB34070

Anti-CD5 antibody [CC17]

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Mouse Monoclonal CD5 antibody. Suitable for Flow Cyt and reacts with Cow samples. Cited in 1 publication. Immunogen corresponding to Cell preparation containing CD5 protein.

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Flow Cytometry - Anti-CD5 antibody [CC17] (AB34070)

Flow Cyt

Supplier Data

Flow Cytometry - Anti-CD5 antibody [CC17] (AB34070)

Staining of bovine peripheral blood lymphocytes with Mouse anti Bovine CD5.

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

CC17

Isotype

IgG1

Carrier free

Reacts with

Cow

Applications

Flow Cyt

applications

Immunogen

Cell preparation containing CD5 protein. The exact immunogen used to generate this antibody is proprietary information.

P19238

Specificity

ab34070 is specific for bovine CD5. This clone reacts with BoCD5.1, which is a polymorphic antigen expressed on cells of all Bos Taurus animals and a small proportion of Bos Indicus animals.

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대체품

Primary Antibodies

AB213004

Anti-CD5 antibody [C5/473 + CD5/54/F6] - BSA and Azide free

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD5 antibody [C5/473 + CD5/54/F6] - BSA and Azide free (AB213004)

Primary Antibodies

AB200697

Anti-CD5 antibody [C5/473 + CD5/54/F6]

Primary Antibodies

AB16699

Anti-CD5 antibody [SP19]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD5 antibody [SP19] (AB16699)

Primary Antibodies

AB134174

Anti-CD5 antibody [EPR2953]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-CD5 antibody [EPR2953] (AB134174)

Primary Antibodies

AB75877

Anti-CD5 antibody [EP2952]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD5 antibody [EP2952] (AB75877)

Primary Antibodies

AB194821

Anti-CD5 antibody [EP2952] - BSA and Azide free

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD5 antibody [EP2952] - BSA and Azide free (AB194821)

Primary Antibodies

AB239796

Anti-CD5 antibody [SP19] - BSA and Azide free

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD5 antibody [SP19] - BSA and Azide free (AB239796)

Primary Antibodies

AB155375

PE/Cy7® Anti-CD5 antibody [UCHT2]

Flow Cytometry - PE/Cy7® Anti-CD5 antibody [UCHT2] (AB155375)

보완 제품

Assay Kits

AB314853

Human CD5 ELISA Kit - Extracellular

SimpleStep

Sandwich ELISA - Human CD5 ELISA Kit - Extracellular (AB314853)

Primary Antibodies

AB16669

Anti-CD3 epsilon antibody [SP7]

Multiplex immunohistochemistry - Anti-CD3 epsilon antibody [SP7] (AB16669)

Primary Antibodies

AB16667

Anti-Ki67 antibody [SP6]

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ki67 antibody [SP6] (AB16667)

Primary Antibodies

AB109296

Anti-CD7 antibody [EPR4242]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-CD7 antibody [EPR4242] (AB109296)

Primary Antibodies

AB134175

Anti-Cyclin D1 antibody [EPR2241] - C-terminal

Western blot - Anti-Cyclin D1 antibody [EPR2241] - C-terminal (AB134175)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Cow": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "10 µL for 10^6 Cells", "FlowCyt-species-notes": "<p><a href='/ko/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

보관 버퍼

Preservative: 0.09% Sodium azide

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CD5 also known as T1 or Leu-1 is a glycoprotein with a molecular mass of approximately 67 kDa. It is expressed mainly on the surface of T cells and a subset of B cells. CD5 plays a major role in the regulation of immune responses. It functions by modulating T-cell receptor (TCR) signaling often acting as a negative regulator to prevent excessive immune activation. Researchers often utilize CD5 antibodies such as those conjugated with PerCP for immunohistochemistry (IHC) to study this protein's expression and distribution.

Biological function summary

CD5 is essential in the immune system's ability to maintain tolerance to self-antigens thereby preventing autoimmune responses. CD5 forms part of a receptor complex on the cell surface that interacts with ligands and other receptors to fine-tune immune cell signaling. Its localization and function in T cells relate closely to its ability to modulate signaling pathways essential for cell survival and proliferation. This modulation is important for ensuring that immune responses are appropriate to the stimuli encountered.

Pathways

CD5 is involved in signal transduction processes important for immune tolerance and modulation. It intersects with pathways like the T cell receptor (TCR) signaling pathway and the NF-kB signaling pathway. These pathways involve interaction with proteins like Zap70 a tyrosine kinase related to TCR signaling and the downstream activation of transcription factors that regulate immune responses. The protein CRIS1 also appears in some pathway interactions highlighting the interconnected nature of immune regulatory proteins.

CD5 has significant associations with autoimmune diseases such as systemic lupus erythematosus (SLE) where its modulatory role can affect autoantibody production. Additionally CD5 in conjunction with proteins like OX19 correlates with certain lymphoproliferative disorders including chronic lymphocytic leukemia (CLL). In these disorders the expression and function of CD5 may impact disease progression and patient response to therapy making it a potential target for intervention in immune-related conditions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

May act as a receptor in regulating T-cell proliferation.

See full target information CD5

대체 명칭 보기

CD5, T-cell surface glycoprotein CD5

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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Veterinary immunology and immunopathology 19:127-39 PubMed3055661

1988

Two monoclonal antibodies (CC17, CC29) recognizing an antigen (Bo5) on bovine T lymphocytes, analogous to human CD5.

Applications

Unspecified application

Species

Unspecified reactive species

C J Howard,K R Parsons,B V Jones,P Sopp,D H Pocock

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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