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AB33273

Anti-CD57 antibody [TB01]

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(2 제품이 사용된 논문 )

Mouse Monoclonal CD57 antibody. Suitable for Flow Cyt, IHC-P, IHC-Fr and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Cell preparation containing CD57 protein.

관련 conjugated 항체와 다양한 조성의 항체 (3)

  • 660 APC

    APC Anti-CD57 antibody [TB01]

  • 519 FITC

    FITC Anti-CD57 antibody [TB01]

  • 578 PE

    PE Anti-CD57 antibody [TB01]

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

TB01

Isotype

IgM

Carrier free

No

Reacts with

Human

Applications

IHC-Fr, IHC-P, Flow Cyt

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "IHCFr" : {"fullname" : "Immunohistochemistry (Frozen sections)", "shortname":"IHC-Fr"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "1/50 - 1/100", "FlowCyt-species-notes": "<p><a href='/ko/products/primary-antibodies/mouse-igm-b11-7-isotype-control-ab91545'>ab91545</a> - Mouse monoclonal IgM, is suitable for use as an isotype control with this antibody.</p><p>Use 10μl of the suggested working dilution to label 10<sup>6</sup> cells in 100μl.</p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "1/10 - 1/50", "IHCP-species-notes": "<p>This product does not require protein digestion pre-treatment of paraffin sections. This product does not require antigen retrieval using heat treatment prior to staining of paraffin sections but sodium citrate buffer may enhance staining.</p>", "IHCFr-species-checked": "guaranteed", "IHCFr-species-dilution-info": "1/10 - 1/100", "IHCFr-species-notes": "<p></p>", "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "WB-species-checked": "notRecommended", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>" } } }

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Ion exchange chromatography
보관 버퍼
pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CD57 also known as HNK-1 is a glycoprotein with a molecular weight of approximately 110 to 150 kDa. It is a marker expressed on the surface of natural killer (NK) cells T lymphocytes and some subsets of CD8+ T cells. Besides you can find this marker in neural tissue. As a surface marker CD57 is used in human immunohistochemistry (IHC) studies to identify cell populations in immune responses and has significant utility in the characterization of lymphocyte subsets.
Biological function summary

CD57 plays a role in immune regulation and cell-mediated cytotoxicity. CD57+ cells which are often mature or post-activation states in NK cells and T lymphocytes are less proliferative but have enhanced cytotoxic abilities. These cells contribute to the immune surveillance against viral infections and tumor cells. CD57 does not belong to any well-known protein complexes but can cooperate with other surface markers to modulate immune functions.

Pathways

CD57+ cell populations participate in the immune system pathways related to cell-mediated immunity and cytotoxic response. The presence of CD57 is often associated with the downregulation of proliferative pathways and the enhancement of cytotoxic pathways. It shows functional overlap with proteins such as CD16 and NKG2D which also play roles in mediating the cytotoxic activity of NK cells.

CD57 is connected to chronic infections and certain autoimmune conditions. In chronic viral infections like HIV CD57+ T cells show a state of replicative senescence where their persistent expression links to disease progression. In autoimmune disorders like rheumatoid arthritis CD57+ T cells are found in the inflamed tissues. This protein works alongside CD8 in conditions of immune dysfunction providing insights into immune status and disease activity.

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

타겟 정보

See full target information CD57

대체 명칭 보기

HKN1, LEU7

제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

British journal of cancer 131:258-270 PubMed38834745

2024

CD57 defines a novel cancer stem cell that drive invasion of diffuse pediatric-type high grade gliomas.

Applications

Unspecified application

Species

Unspecified reactive species

Lin Qi,Yuchen Du,Yulun Huang,Mari Kogiso,Huiyuan Zhang,Sophie Xiao,Aalaa Abdallah,Milagros Suarez,Long Niu,Zhi-Gang Liu,Holly Lindsay,Frank K Braun,Clifford Stephen,Peter J Davies,Wan Yee Teo,Adesina Adenkunle,Patricia Baxter,Jack Mf Su,Xiao-Nan Li

Journal of leukocyte biology 76:667-75 PubMed15178706

2004

Unique phenotype of human uterine NK cells and their regulation by endogenous TGF-beta.

Applications

Unspecified application

Species

Unspecified reactive species

Mikael Eriksson,Sarah K Meadows,Charles R Wira,Charles L Sentman
제품이 사용된 논문 모두 보기

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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