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AB8239

Anti-CD80 antibody [MEM-233]

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(2 제품이 사용된 논문 )

Mouse Monoclonal CD80 antibody. Suitable for IP, Flow Cyt and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CD80.

관련 conjugated 항체와 다양한 조성의 항체 (7)

  • 660 APC

    APC Anti-CD80 antibody [MEM-233]

  • 723 Alexa Fluor® 700

    Alexa Fluor® 700 Anti-CD80 antibody [MEM-233]

  • 519 FITC

    FITC Anti-CD80 antibody [MEM-233]

  • 578 PE

    PE Anti-CD80 antibody [MEM-233]

  • 667 PE/Cy5®

    PE/Cy5® Anti-CD80 antibody [MEM-233]

  • 778 PE/Cy7®

    PE/Cy7® Anti-CD80 antibody [MEM-233]

  • 675 PerCP

    PerCP Anti-CD80 antibody [MEM-233]

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

MEM-233

Isotype

IgG1

Light chain 타입

unknown

Carrier free

No

Reacts with

Human

Applications

IP, Flow Cyt

applications

Immunogen

Recombinant Fragment Protein within Human CD80. The exact immunogen used to generate this antibody is proprietary information.

P33681

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대체품

Primary Antibodies

AB225674

Anti-CD80 antibody [EPR22183]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-CD80 antibody [EPR22183] (AB225674)

  • 5
  • 1
Primary Antibodies

AB134120

Anti-CD80 antibody [EPR1157(2)]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD80 antibody [EPR1157(2)] (AB134120)

  • 4
  • 2
Primary Antibodies

AB222702

Anti-CD80 antibody [EPR22127-251]

20ul selling size|RabMAb|Recombinant|Trial Size

Flow Cytometry - Anti-CD80 antibody [EPR22127-251] (AB222702)

  • 0
  • 0
Primary Antibodies

AB238649

Anti-CD80 antibody [EPR22127-251] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry - Anti-CD80 antibody [EPR22127-251] - BSA and Azide free (AB238649)

  • 0
  • 0
Primary Antibodies

AB224797

Anti-CD80 antibody [EPR1157(2)] - Low endotoxin, Azide free

BOND RX™ Validated|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD80 antibody [EPR1157(2)] - Low endotoxin, Azide free (AB224797)

  • 0
  • 1
Primary Antibodies

AB238648

Anti-CD80 antibody [EPR22183] - BSA and Azide free

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-CD80 antibody [EPR22183] - BSA and Azide free (AB238648)

  • 0
  • 0
Primary Antibodies

AB238481

Anti-CD80 antibody [EPR22127-317]

20ul selling size|RabMAb|Recombinant

Western blot - Anti-CD80 antibody [EPR22127-317] (AB238481)

  • 0
  • 0

보완 제품

Assay Kits

AB256392

Human CD80 ELISA Kit (B7-1)

Recombinant|SimpleStep

Sandwich ELISA - Human CD80 ELISA Kit (B7-1) (AB256392)

  • 0
  • 0
Primary Antibodies

AB64693

Anti-CD206 antibody

BOND RX™ Validated

Western blot - Anti-CD206 antibody (AB64693)

  • 5
  • 42
Primary Antibodies

AB20181

Anti-HLA-DR antibody [TAL 1B5]

Recombinant|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-HLA-DR antibody [TAL 1B5] (AB20181)

  • 5
  • 6
Primary Antibodies

AB283655

Anti-iNOS antibody [RM1017]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-iNOS antibody [RM1017] (AB283655)

  • 0
  • 1
Primary Antibodies

AB213363

Anti-CD68 antibody [EPR20545]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Advanced Validation

Multiplex immunohistochemistry - Anti-CD68 antibody [EPR20545] (AB213363)

  • 4
  • 6
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "guaranteed", "IP-species-dilution-info": "", "IP-species-notes": "<p></p>", "FlowCyt-species-checked": "guaranteed", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "<p><a href='/ko/products/primary-antibodies/mouse-igg1-kappa-monoclonal-15-6e10a7-isotype-control-ab170190'>ab170190</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }
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제품 세부 정보

This product was changed from ascites to tissue culture supernatant on 24th January 2018. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein A
Purification 관련 사항
Purified from TCS. Purity >95% by SDS-PAGE.
보관 버퍼
pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CD80 also known as B7-1 is a cell surface protein with a molecular weight of approximately 60 kDa. It is expressed on antigen-presenting cells such as dendritic cells macrophages and B cells. The CD80 protein plays a mechanical role in immune response modulation by providing necessary signals for T cell activation and survival. CD80 interacts with receptors CD28 and CTLA-4 on T cells serving as a costimulatory molecule important for productive immune responses.
Biological function summary

CD80 plays a significant role in the immune system's ability to distinguish between self and non-self. It belongs to the B7 family and participates in the formation of immunological synapses between T cells and antigen-presenting cells. This interaction is essential for triggering T cell proliferation and cytokine production forming a part of the adaptive immune response. CD80's expression increases in response to pathogen recognition enhancing the immune system's efficiency.

Pathways

CD80 is integral to the regulation of T cell-mediated immune responses. It is involved in the CD28 co-stimulatory pathway which is vital for T cell activation and function. In this pathway CD80 interacts with proteins like CD28 and CTLA-4 to modulate immune activation and regulate immune tolerance. The proper function of CD80 within this pathway ensures a balanced immune reaction preventing autoimmunity while allowing effective defense against pathogens.

CD80 plays a role in autoimmune conditions and transplantation rejection. Its overexpression or dysregulation can contribute to diseases such as rheumatoid arthritis where it modifies T cell response and inflammation. Additionally CD80 is implicated in organ transplantation influencing graft rejection outcomes due to its role in modulating immune activation. Understanding CD80 interactions with CTLA-4 and CD28 offers insight into these conditions providing potential targets for therapeutic intervention.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Costimulatory molecule that belongs to the immunoglobulin superfamily that plays an important role in T-lymphocyte activation (PubMed : 38467718). Acts as the primary auxiliary signal augmenting the MHC/TCR signal in naive T-cells by acting as a ligand for the CD28 receptor which is constitutively expressed on the cell surface of T-cells (PubMed : 12196291). In turn, activates different signaling pathways such as NF-kappa-B or MAPK leading to the production of different cytokines (PubMed : 10438913). Also acts as an inhibitor of T-cell activation by acting as a ligand for CTLA4, a decoy receptor, thereby blocking CD28-mediated T-cell priming (PubMed : 10583602, PubMed : 11279502). In addition, CD28/CD80 costimulatory signal stimulates glucose metabolism and ATP synthesis of T-cells by activating the PI3K/Akt signaling pathway (PubMed : 12121659). Also acts as a regulator of PDL1/PDCD1 interactions to limit excess engagement of PDL1 and its inhibitory role in immune responses (PubMed : 36727298). Expressed on B-cells, plays a critical role in regulating interactions between B-cells and T-cells in both early and late germinal center responses, which are crucial for the generation of effective humoral immune responses (By similarity).. (Microbial infection) Acts as a receptor for adenovirus subgroup B.
See full target information CD80

대체 명칭 보기

CD80, CD28LG, CD28LG1, LAB7, T-lymphocyte activation antigen CD80, Activation B7-1 antigen, BB1, CTLA-4 counter-receptor B7.1, B7
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

International journal of molecular sciences 16:758-87 PubMed25561230

2014

Motor, visual and emotional deficits in mice after closed-head mild traumatic brain injury are alleviated by the novel CB2 inverse agonist SMM-189.

Applications

Unspecified application

Species

Unspecified reactive species

Anton Reiner,Scott A Heldt,Chaela S Presley,Natalie H Guley,Andrea J Elberger,Yunping Deng,Lauren D'Surney,Joshua T Rogers,Jessica Ferrell,Wei Bu,Nobel Del Mar,Marcia G Honig,Steven N Gurley,Bob M Moore

The Journal of investigative dermatology 128:988-98 PubMed17960177

2007

Evaluation of twenty-one human adenovirus types and one infectivity-enhanced adenovirus for the treatment of malignant melanoma.

Applications

Unspecified application

Species

Unspecified reactive species

Dennis Hoffmann,Wibke Bayer,Albert Heim,Anja Potthoff,Dirk M Nettelbeck,Oliver Wildner
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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