AB205343

Anti-CD83 antibody

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(6 제품이 사용된 논문 )

Rabbit Polyclonal CD83 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 6 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CD83 aa 50-150.

대체 명칭 보기

CD83, CD83 antigen, hCD83, B-cell activation protein, Cell surface protein HB15

5 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD83 antibody (AB205343)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD83 antibody (AB205343)

Immunohistochemical analysis of formalin/PFA-fixed paraffin-embedded human tonsil tissue sections labeling CD83 with ab205343 at a 1/50 dilution.

Immunocytochemistry/ Immunofluorescence - Anti-CD83 antibody (AB205343)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-CD83 antibody (AB205343)

Immunofluorescence analysis of formalin fixed, Triton X-100 permealized A431 cells, labeling CD83 with ab205343 at 4 μg/mL.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD83 antibody (AB205343)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD83 antibody (AB205343)

Immunohistochemical analysis of human colon tissue labeling CD83 with ab205343 at 1/200 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD83 antibody (AB205343)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD83 antibody (AB205343)

Immunohistochemical analysis of human enometrium tissue labeling CD83 with ab205343 at 1/200 dilution.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD83 antibody (AB205343)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD83 antibody (AB205343)

Immunohistochemical analysis of human tonsil tissue labeling CD83 with ab205343 at 1/200 dilution.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

Immunogen

Recombinant Fragment Protein within Human CD83 aa 50-150. The exact immunogen used to generate this antibody is proprietary information.

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대체품

Primary Antibodies

AB244204

Anti-CD83 antibody [EPR22405]

20ul selling size|RabMAb|Recombinant

Flow Cytometry - Anti-CD83 antibody [EPR22405] (AB244204)

0
0

Primary Antibodies

AB234233

PE/Cy5® Anti-CD83 antibody [HB15e]

Flow Cytometry - PE/Cy5® Anti-CD83 antibody [HB15e] (AB234233)

0
0

Primary Antibodies

AB234119

APC Anti-CD83 antibody [HB15e]

Flow Cytometry - APC Anti-CD83 antibody [HB15e] (AB234119)

0
0

Primary Antibodies

AB234242

PE Anti-CD83 antibody [HB15e]

Flow Cytometry - PE Anti-CD83 antibody [HB15e] (AB234242)

0
0

Primary Antibodies

AB48318

FITC Anti-CD83 antibody [Michel-19]

Flow Cytometry - FITC Anti-CD83 antibody [Michel-19] (AB48318)

0
0

Primary Antibodies

AB245986

Anti-CD83 antibody [EPR22405] - BSA and Azide free

RabMAb|Recombinant

Flow Cytometry - Anti-CD83 antibody [EPR22405] - BSA and Azide free (AB245986)

0
0

Primary Antibodies

AB233782

Anti-CD83 antibody [8A4C11]

Western blot - Anti-CD83 antibody [8A4C11] (AB233782)

0
0

보완 제품

Primary Antibodies

AB131254

Anti-CD27 antibody [EPR8569]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-CD27 antibody [EPR8569] (AB131254)

5
2

Primary Antibodies

AB317266

Anti-CD86 antibody [EPR28721-30]

BOND RX™ Validated|20ul selling size|Recombinant|RabMAb|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD86 antibody [EPR28721-30] (AB317266)

0
0

Primary Antibodies

AB200315

Alexa Fluor® 488 Anti-CD45 antibody [EP322Y]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Alexa Fluor® 488 Anti-CD45 antibody [EP322Y] (AB200315)

0
0

Primary Antibodies

AB133616

Anti-CD4 antibody [EPR6855]

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD4 antibody [EPR6855] (AB133616)

5
20

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/200", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CD83 also known as 3D11 in some contexts is a protein with important roles in the immune system. The CD83 protein is a glycoprotein with a molecular mass of approximately 45 kDa. It is expressed in various immune cells including dendritic cells B cells thymic epithelial cells and activated T cells. CD83 acts as a surface marker during the maturation and activation of these cells. This characteristic makes it a useful marker in immunological studies often referred to by scientists as the CD83 marker.

Biological function summary

The primary role of CD83 involves the regulation of immune responses. It functions by modulating the activity and communication of immune cells especially impacting the antigen-presenting capabilities of dendritic cells. CD83 also plays a role in promoting the maturation of these cells and influencing T-cell responses. Although CD83 is not generally recognized as a part of a complex its interactions with other cell surface molecules are significant for immune system function.

Pathways

CD83 has notable involvement in immune signaling pathways including the NF-kB and JAK/STAT pathways. These pathways are critical for transmitting signals that influence cell survival proliferation and activation. Through these pathways CD83 interacts with proteins such as cytokines and growth factors which further modulate their effects on immune cells and their responses.

Understanding CD83’s role provides insights into conditions like autoimmune diseases and immune deficiencies. In autoimmune diseases irregular expression or function of CD83 can disrupt normal immune response contributing to pathogenesis. Its relationship with other proteins such as CD28 in T-cell activation underlies its involvement in disorders characterized by immune dysregulation. Furthermore CD83 expression profiles may help decipher cancer immune evasion mechanisms providing possible therapeutic targets.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Transmembrane glycoprotein predominantly found on the surface of many immune cells including dendritic cells or lymphocytes that plays various roles in immune response regulation. Plays an essential role in CD4(+) T-selection, differentiation and stability by regulating the activity of the major E3 ubiquitin ligase responsible for controlling MHCII trafficking MARCHF8. Also inhibits MARCHF1 association with MHCII or CD86 to prevent their ubiquitination and subsequent degradation (PubMed : 21220452). In addition, acts as an important modulator of protective responses against acute infections (By similarity).

See full target information CD83

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제품이 사용된 논문 (6)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of clinical medicine 13: PubMed38610835

2024

The Impact of Phenotype of Inflammatory Bowel Diseases, Inflammation Activity and Therapy on Mucosal Mature Cd83 Dendritic Cell.

Applications

Unspecified application

Species

Unspecified reactive species

Bruna Rošić Despalatović,Marija Babić,Andre Bratanić,Ante Tonkić,Žarko Ardalić,Katarina Vilović

Aging 13:14131-14158 PubMed34001679

2021

Downregulation of USP18 reduces tumor-infiltrating activated dendritic cells in extranodal diffuse large B cell lymphoma patients.

Applications

Unspecified application

Species

Unspecified reactive species

Chong Zhao,Runzhi Huang,Zhiwei Zeng,Shaoxin Yang,Wei Lu,Jiali Liu,Yanyu Wei,Hezhou Guo,Yanjie Zhang,Penghui Yan,Zongqiang Huang,Jun Shi

Methods in molecular biology (Clifton, N.J.) 2265:573-587 PubMed33704741

2021

Multiplex Immunofluorescence Histology for Immune Cell Infiltrates in Melanoma-Associated Tertiary Lymphoid Structures.

Applications

Unspecified application

Species

Unspecified reactive species

Ileana S Mauldin,Adela Mahmutovic,Samuel J Young,Craig L Slingluff

Cancers 12: PubMed32823589

2020

CD83, a Novel MAPK Signaling Pathway Interactor, Determines Ovarian Cancer Cell Fate.

Applications

Unspecified application

Species

Unspecified reactive species

Aalia Batool,Hao Liu,Yi-Xun Liu,Su-Ren Chen

Scientific reports 10:10055 PubMed32572123

2020

Difference in Presence and Number of CD83 Dendritic Cells in Patients with Ulcerative Colitis and Crohn's Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Bruna Rošić Despalatović,Marija Babić,Andre Bratanić,Ante Tonkić,Katarina Vilović

Clinical and experimental immunology 188:420-429 PubMed28052400

2017

Programmed death-1 ligands 1 and 2 expression in cutaneous squamous cell carcinoma and their relationship with tumour- infiltrating dendritic cells.

Applications

Unspecified application

Species

Unspecified reactive species

Q Jiao,C Liu,W Li,W Li,F Fang,Q Qian,X Zhang

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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