JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB190718

Anti-CEACAM1 + CEACAM5 antibody [C66/261]

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Mouse Monoclonal CEACAM5 antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CEACAM5.

대체 명칭 보기

CD66e, CEA, CEACAM5, Cell adhesion molecule CEACAM5, Carcinoembryonic antigen, Carcinoembryonic antigen-related cell adhesion molecule 5, Meconium antigen 100, CEA cell adhesion molecule 5, CD66a, BGP, BGP1, CEACAM1, Cell adhesion molecule CEACAM1, Biliary glycoprotein 1, Carcinoembryonic antigen-related cell adhesion molecule 1, BGP-1, CEA cell adhesion molecule 1

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEACAM1 + CEACAM5 antibody [C66/261] (AB190718)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEACAM1 + CEACAM5 antibody [C66/261] (AB190718)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human colon carcinoma tissue labeling CEACAM1 + CEACAM5 with ab190718 at 0.5 μg/mL.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEACAM1 + CEACAM5 antibody [C66/261] (AB190718)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEACAM1 + CEACAM5 antibody [C66/261] (AB190718)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human colon carcinoma tissue labeling CEACAM1 + CEACAM5 with ab190718 at 0.5 μg/mL.

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

C66/261

Isotype

IgG1

Light chain 타입

kappa

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CEACAM5.

P06731

style
left-column

대체품

Primary Antibodies

AB91213

Anti-CEACAM1 + CEACAM5 antibody [4/3/17]

Flow Cytometry - Anti-CEACAM1 + CEACAM5 antibody [4/3/17] (AB91213)

  • 0
  • 0

보완 제품

Assay Kits

AB215540

Human CEACAM1 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human CEACAM1 ELISA Kit (AB215540)

  • 0
  • 0
Primary Antibodies

AB255607

Anti-ErbB3 / HER3 antibody [EPR22669-25]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ErbB3 / HER3 antibody [EPR22669-25] (AB255607)

  • 0
  • 0
Primary Antibodies

AB227637

Anti-Met (c-Met) antibody [SP44] - C-terminal

RabMAb|Recombinant|KO Validated|20ul selling size

Flow Cytometry (Intracellular) - Anti-Met (c-Met) antibody [SP44] - C-terminal (AB227637)

  • 5
  • 1
Primary Antibodies

AB229902

Anti-DLL3 antibody [EPR22592-18]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-DLL3 antibody [EPR22592-18] (AB229902)

  • 0
  • 0
Primary Antibodies

AB214488

Anti-TROP2 antibody [EPR20043]

20ul selling size|BOND RX™ Validated|KO Validated|RabMAb|Recombinant

Western blot - Anti-TROP2 antibody [EPR20043] (AB214488)

  • 5
  • 9
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1-2 µg/mL", "IHCP-species-notes": "<p></p>" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
보관 버퍼
pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 0.05% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CEACAM1 and CEACAM5 are members of the carcinoembryonic antigen (CEA) family also referred to as CD66a and CD66e respectively. CEACAM1 with a molecular weight of approximately 120 kDa and CEACAM5 weighing around 200 kDa serve as cell surface glycoproteins. They localize primarily on epithelial cells and are also expressed in immune cells such as neutrophils and lymphocytes. These proteins mediate intercellular interactions and play roles in cell adhesion and signaling.
Biological function summary

These CEACAM proteins modulate immune responses and maintain epithelial tissue architecture. CEACAM1 acts as a regulator of immune cell signaling and participates in microbial recognition. It is part of complexes with other signaling molecules due to its cytoplasmic domain that interacts with intracellular adaptors. CEACAM5 enhances cell adhesion and is important for maintaining cellular integrity.

Pathways

CEACAM1 and CEACAM5 participate in immune and signaling pathways. CEACAM1 modulates the PI3K-Akt pathway influencing cell proliferation and survival. It associates closely with proteins such as SHP-1 and SHP-2 which act as phosphatase regulators. CEACAM5 is involved in the MAPK pathway which influences cell growth regulation and is linked to cellular responses to external stimuli.

CEACAM1 and CEACAM5 are associated with cancer and inflammatory diseases. CEACAM5 is a known biomarker for colorectal cancer where it can be overexpressed leading to tumor progression. CEACAM1 correlates with melanoma as its expression levels can affect tumor immune evasion. Both proteins are targets for therapeutic interventions in cancer interacting with immune checkpoint molecules like PD-1 in tumor environments.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed : 10864933, PubMed : 10910050, PubMed : 2803308). Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed : 2803308). Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed : 10910050).. (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.
See full target information CEACAM5

Additional targets

CEACAM1
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Experimental hematology & oncology 14:26 PubMed40025520

2025

TLR7/8 signaling activation enhances the potency of human pluripotent stem cell-derived eosinophils in cancer immunotherapy for solid tumors.

Applications

Unspecified application

Species

Unspecified reactive species

Sheng Zhu,Zhengyang Zhou,Ruixin Gu,Zixin Zhao,Yingfeng Zhang,Yudi Miao,Qi Lei,Tianxing Liu,Guokai Wang,Chenyi Dai,Yi Huo,Jinghao You,Lejun Lv,Cheng Li,Ming Yin,Chengyan Wang,Hongkui Deng
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com