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AB235513

Anti-CEP63 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal CEP63 antibody. Suitable for IHC-P, WB and reacts with Human, Mouse samples. Cited in 2 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CEP63 aa 1-500.

대체 명칭 보기

Centrosomal protein of 63 kDa, Cep63, CEP63

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEP63 antibody (AB235513)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CEP63 antibody (AB235513)

Paraffin-embedded human prostate cancer tissue stained for CEP63 using ab235513 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human CEP63 aa 1-500. The exact immunogen used to generate this antibody is proprietary information.

Q96MT8

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보완 제품

Primary Antibodies

AB52866

Anti-alpha Tubulin antibody [EP1332Y] - Loading Control

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size|Trial Size

Immunocytochemistry/ Immunofluorescence - Anti-alpha Tubulin antibody [EP1332Y] - Loading Control (AB52866)

  • 5
  • 31
Primary Antibodies

AB11316

Anti-gamma Tubulin antibody [GTU-88] - Centrosome Marker

Lab Essentials

Western blot - Anti-gamma Tubulin antibody [GTU-88] - Centrosome Marker (AB11316)

  • 4
  • 17
Primary Antibodies

AB309229

Anti-GBA antibody [EPR26755-42] - BSA and Azide free (Detector)

RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-GBA antibody [EPR26755-42] - BSA and Azide free (Detector) (AB309229)

  • 0
  • 0
Primary Antibodies

AB179484

Anti-alpha Tubulin (acetyl K40) antibody [EPR16772]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha Tubulin (acetyl K40) antibody [EPR16772] (AB179484)

  • 5
  • 4
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" }, "Mouse": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CEP63 also known as Centrosomal protein 63 or CT63 is a centrosomal protein weighing approximately 79 kDa. It localizes to the centrosome an important organelle involved in cell cycle regulation. CEP63 plays an important mechanical role in centrosomal duplication. It is expressed in various tissues with higher levels noted in rapidly dividing cells particularly in testes and the brain.
Biological function summary

The functions of CEP63 extend to nucleating microtubules and maintaining centrosome cohesion. It requires association with proteins like CEP152 as part of the centrosome complex. CEP63 stabilizes the centrosome ensuring adequate centrioles duplication which is essential for cell division and maintaining genomic stability.

Pathways

CEP63 integrates into the DNA damage response and cell cycle pathways. Its role in these pathways aligns with the proteins ATR and TP53 which are important for sensing DNA damage and initiating repair or apoptosis. CEP63's involvement in these pathways supports its function in preventing genomic instability and unchecked cell division.

CEP63 has strong links to microcephaly a condition characterized by reduced brain size due to ineffective cell division in neural tissues. CEP63 mutations also connect to Seckel syndrome another disorder impacting growth and development. These disorders reveal insights into the protein's relationship with centrosome-associated proteins and DNA repair components like ATR and BRCA1 underlining its role in neurodevelopmental and proliferative pathologies.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Required for normal spindle assembly (PubMed : 21406398, PubMed : 21983783, PubMed : 26297806, PubMed : 35793002). Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed : 21983783, PubMed : 26297806). Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed : 21983783, PubMed : 26297806). Also recruits CDK1 to centrosomes (PubMed : 21406398). Plays a role in DNA damage response (PubMed : 21406398). Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed : 21406398). Promotes stabilization of FXR1 protein by inhibiting FXR1 ubiquitination (PubMed : 35989368).
See full target information CEP63
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Oncology reports 46: PubMed34296302

2021

Cep63 knockout inhibits the malignant phenotypes of papillary thyroid cancer cell line TPC‑1.

Applications

Unspecified application

Species

Unspecified reactive species

Chenguang Liu,Fangqin Yu,Runsheng Ma,Lele Zhang,Gongbo Du,Dongpeng Niu,Detao Yin

Frontiers in cell and developmental biology 9:686886 PubMed34150781

2021

Platelet-Derived Growth Factor-D Activates Complement System to Propagate Macrophage Polarization and Neovascularization.

Applications

Unspecified application

Species

Unspecified reactive species

Zhen Xiong,Qianqian Wang,Wanhong Li,Lijuan Huang,Jianing Zhang,Juanhua Zhu,Bingbing Xie,Shasha Wang,Haiqing Kuang,Xianchai Lin,Chunsik Lee,Anil Kumar,Xuri Li
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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