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AB215042

Anti-CES2 antibody

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(3 제품이 사용된 논문 )

Sheep Polyclonal EST2C antibody. Suitable for WB and reacts with Mouse samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Mouse Ces2c aa 1 to C-terminus.

대체 명칭 보기

Ces2, Ces2c, Acylcarnitine hydrolase, ACH M1, Carboxylesterase 2, Carboxylic ester hydrolase, Peroxisome proliferator-inducible acylcarnitine hydrolase, CES 2

1 이미지
Western blot - Anti-CES2 antibody (AB215042)
  • WB

Supplier Data

Western blot - Anti-CES2 antibody (AB215042)

All lanes:

Western blot - Anti-CES2 antibody (ab215042) at 1/1000 dilution

All lanes:

Mouse liver tissue lysate

Predicted band size: 62 kDa

Observed band size: 58-62 kDa

false

주요 정보

Host species

Sheep

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

WB

applications

Immunogen

Recombinant Fragment Protein within Mouse Ces2c aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q91WG0

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대체품

Primary Antibodies

AB137606

Anti-CES2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CES2 antibody (AB137606)

  • 0
  • 0
Primary Antibodies

AB126970

Anti-CES2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CES2 antibody (AB126970)

  • 0
  • 0
Primary Antibodies

AB88439

Anti-CES2 antibody

Western blot - Anti-CES2 antibody (AB88439)

  • 0
  • 0
Primary Antibodies

AB184957

Anti-CES2 antibody [EPR14856]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CES2 antibody [EPR14856] (AB184957)

  • 1
  • 1

보완 제품

Primary Antibodies

AB184957

Anti-CES2 antibody [EPR14856]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CES2 antibody [EPR14856] (AB184957)

  • 1
  • 1
Primary Antibodies

AB45957

Anti-Liver Carboxylesterase 1/CES1 antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Liver Carboxylesterase 1/CES1 antibody (AB45957)

  • 0
  • 0
Primary Antibodies

AB288296

Anti-ADA2 antibody [EPR25430-131]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|Trial Size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ADA2 antibody [EPR25430-131] (AB288296)

  • 0
  • 0
Primary Antibodies

AB109524

Anti-Topoisomerase II alpha + Topoisomerase II beta/TOP2B antibody [EPR5377]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Topoisomerase II alpha + Topoisomerase II beta/TOP2B antibody [EPR5377] (AB109524)

  • 5
  • 2
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/2000", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
The IgG fraction of immunized serum was purified by antigen affinity chromatography.
보관 버퍼
Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Carboxylesterase 2 (CES2) also known as intestinal carboxylesterase is an enzyme with a molecular mass of approximately 60 kDa. CES2 hydrolyzes esters and amides affecting metabolism of drugs and xenobiotics. It is found mainly in the liver and small intestine with lesser expression in the colon kidney and brain. This distribution enables CES2 to play a role in both intestinal and systemic drug metabolism.
Biological function summary

CES2 acts in the hydrolysis process converting prodrugs into active compounds. It functions independently and is not typically part of a larger complex. This enzyme demonstrates broad substrate specificity impacting the metabolic activation of several therapeutic agents. Its activity affects the bioavailability and activation of medicines such as irinotecan and capecitabine which are used in cancer treatments.

Pathways

CES2 takes part in the drug metabolism pathway involving cytochrome P450 enzymes. It interacts with CYP3A4 one of the key enzymes in this system and facilitates the conversion of chemical compounds into pharmacologically active or inactive metabolites. CES2 also participates in lipid metabolism affecting the ester and triglyceride hydrolysis alongside lipases and other related enzymes.

CES2 has implications in colorectal cancer and liver disease conditions where altered drug metabolism influences disease progression and treatment efficacy. It shows associations with irinotecan activation a drug used for treating colorectal cancer and links with UDP-glucuronosyltransferases (UGTs) that also engage in drug metabolism. Understanding CES2's function aids in predicting patient responses to drug therapies and refining treatment strategies for these conditions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Hydrolase with high activity towards palmitoylcarnitine. Is also active with p-nitrophenylacetate and alpha-naphthylacetate. May also hydrolyze retinyl esters (By similarity).
See full target information Ces2c
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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature communications 14:3643 PubMed37339977

2023

Antioxidant hepatic lipid metabolism can be promoted by orally administered inorganic nanoparticles.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Cai,Jie Peng,Juan Feng,Ruocheng Li,Peng Ren,Xinwei Zang,Zezong Wu,Yi Lu,Lin Luo,Zhenzhen Hu,Jiaying Wang,Xiaomeng Dai,Peng Zhao,Juan Wang,Mi Yan,Jianxin Liu,Renren Deng,Diming Wang

Frontiers in oncology 12:1012058 PubMed36338744

2022

Multi-spectral immunofluorescence evaluation of the myeloid, T cell, and natural killer cell tumor immune microenvironment in chordoma may guide immunotherapeutic strategies.

Applications

Unspecified application

Species

Unspecified reactive species

Diana C Lopez,Yvette L Robbins,Joshua T Kowalczyk,Wiem Lassoued,James L Gulley,Markku M Miettinen,Gary L Gallia,Clint T Allen,James W Hodge,Nyall R London

Frontiers in pharmacology 13:843872 PubMed35250593

2022

Combined Use of Bicyclol and Berberine Alleviates Mouse Nonalcoholic Fatty Liver Disease.

Applications

Unspecified application

Species

Unspecified reactive species

Hu Li,Nan-Nan Liu,Jian-Rui Li,Biao Dong,Mei-Xi Wang,Jia-Li Tan,Xue-Kai Wang,Jing Jiang,Lei Lei,Hong-Ying Li,Han Sun,Jian-Dong Jiang,Zong-Gen Peng
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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