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AB195387

Anti-CGRP antibody

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(3 제품이 사용된 논문 )

Sheep Polyclonal CGRP-I antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Rat Calca.

대체 명칭 보기

Calc, Calca, Calcitonin gene-related peptide 1, CGRP1, Alpha-type CGRP, Calcitonin gene-related peptide I, CGRP-I

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CGRP antibody (AB195387)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CGRP antibody (AB195387)

Immunohistochemical analysis of paraffin-embedded Rat thoracolumbar spinal cord tissue labeling CGRP with ab195387 at 1/1000 dilution. Negative images of fluorescence detection procedure (Alexa488 conjugated secondary antibody).

주요 정보

Host species

Sheep

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Rat

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Rat Calca. The exact immunogen used to generate this antibody is proprietary information.

P01256

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대체품

Primary Antibodies

AB36001

Anti-CGRP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CGRP antibody (AB36001)

  • 5
  • 13
Primary Antibodies

AB189786

Anti-CGRP antibody

Immunocytochemistry/ Immunofluorescence - Anti-CGRP antibody (AB189786)

  • 0
  • 1
Primary Antibodies

AB47027

Anti-CGRP antibody

BOND RX™ Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CGRP antibody (AB47027)

  • 4
  • 7
Primary Antibodies

AB81887

Anti-CGRP antibody [4901]

Immunocytochemistry/ Immunofluorescence - Anti-CGRP antibody [4901] (AB81887)

  • 5
  • 9
Primary Antibodies

AB135271

Anti-CGRP antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CGRP antibody (AB135271)

  • 0
  • 0

보완 제품

Assay Kits

AB221828

Human Procalcitonin ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human Procalcitonin ELISA Kit (AB221828)

  • 5
  • 1
Primary Antibodies

AB108986

Anti-PGP9.5 antibody [EPR4118] - Neuronal Marker

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Western blot - Anti-PGP9.5 antibody [EPR4118] - Neuronal Marker (AB108986)

  • 5
  • 12
Primary Antibodies

AB24982

Cy5 ® Anti-CD45.1 antibody [A20]

  • 0
  • 0
Primary Antibodies

AB302667

Anti-c-Fos antibody [N486/32]

BOND RX™ Validated|Recombinant|Lab Essentials|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-c-Fos antibody [N486/32] (AB302667)

  • 0
  • 0
Primary Antibodies

AB183734

Anti-GFP antibody [EPR14104]

RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GFP antibody [EPR14104] (AB183734)

  • 5
  • 24
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000", "IHCP-species-notes": "<p>Perfusion fixation is recommended if possible.</p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Precipitation Ammonium Sulphate
보관 버퍼
Preservative: 0.1% Sodium azide Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CGRP or Calcitonin Gene-Related Peptide is a 37-amino acid neuropeptide with a molecular mass of approximately 3.8 kDa. This peptide exists mainly in two forms alpha-CGRP and beta-CGRP differing slightly in amino acid sequence. CGRP expresses in peripheral and central nervous systems with high levels in the dorsal root ganglia and thyroid gland. It also has a significant presence in the enteric nervous system and some segments of the cardiovascular system. Scientists note that CGRP acts as a potent vasodilator and plays a significant role in transducing pain signals.
Biological function summary

CGRP contributes to numerous physiological processes including blood flow regulation body temperature control pain transmission and neurogenic inflammation. It acts independently and does not substantially form part of larger protein complexes in its primary activities. Through binding to the CGRP receptor a complex made up of the calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 1 (RAMP1) CGRP initiates downstream signaling that results in its various biological effects.

Pathways

Studies place CGRP within the neuropeptide signaling pathway and the vasodilation pathway. It significantly influences the cyclic AMP (cAMP) signaling pathway where it works collaboratively with other neuropeptides like substance P. The interaction with CLR and RAMP1 triggers the production of cAMP which enhances vasodilation and pain transmission processes in the body.

CGRP holds a notable connection to migraines and cardiovascular diseases. Elevated CGRP levels are observed in migraine sufferers and targeted treatments utilizing anti-CGRP antibodies have demonstrated efficacy in reducing migraine frequency. Additionally research links CGRP to blood pressure regulation abnormalities implicating its involvement in hypertension. Both conditions involve complex interactions with other proteins such as substance P and endothelial nitric oxide synthase (eNOS) which modulate vascular tone and inflammation.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

CGRP1/CALCA is a peptide hormone that induces vasodilation mediated by the CALCRL-RAMP1 receptor complex. Dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. It also elevates platelet cAMP. CGRP1 can also bind and activate CALCR-RAMP1 (AMYR1) receptor complex.
See full target information Calca
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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Clinical and experimental pharmacology & physiology 52:e70062 PubMed40776599

2025

PACAP Inhibits TNF-α- Induced Senescence in Primary Chondrocytes by SIRT3: An Implication in Osteoarthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Xuewu Zhou,Kangquan Shou,Hao Yao

Journal of orthopaedic translation 52:97-115 PubMed40275883

2025

PDGF-BB improves cortical bone quality through restoring the osteogenic microenvironment in the steroid-associated osteonecrosis of rabbits.

Applications

Unspecified application

Species

Unspecified reactive species

Huijuan Cao,Keda Shi,Jing Long,Yanzhi Liu,Xiangbo Meng,Cuishan Huang,Jie Hao,Lingli Li,Yiqing Zhao,Tianluo Ye,Yuxiao Lai,Ling Qin,Xinluan Wang

Nature neuroscience 27:2326-2340 PubMed39496796

2024

Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation.

Applications

Unspecified application

Species

Unspecified reactive species

Huasheng Yu,Saad S Nagi,Dmitry Usoskin,Yizhou Hu,Jussi Kupari,Otmane Bouchatta,Hanying Yan,Suna Li Cranfill,Mayank Gautam,Yijing Su,You Lu,James Wymer,Max Glanz,Phillip Albrecht,Hongjun Song,Guo-Li Ming,Stephen Prouty,John Seykora,Hao Wu,Minghong Ma,Andrew Marshall,Frank L Rice,Mingyao Li,Håkan Olausson,Patrik Ernfors,Wenqin Luo
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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