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AB198233

Anti-CHDH antibody - C-terminal

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Rabbit Polyclonal CHDH antibody. C-terminal. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Choline dehydrogenase, mitochondrial.

대체 명칭 보기

CDH, CHD, CHDH

2 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHDH antibody - C-terminal (AB198233)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CHDH antibody - C-terminal (AB198233)

Immunohistochemical analysis of paraffin-embedded Human liver cancer tissue labeling CHDH with ab198233 at 1/20 dilution.

Western blot - Anti-CHDH antibody - C-terminal (AB198233)
  • WB

Supplier Data

Western blot - Anti-CHDH antibody - C-terminal (AB198233)

Gel : 10%SDS-PAGE

All lanes:

Western blot - Anti-CHDH antibody - C-terminal (ab198233) at 1/400 dilution

Lane 1:

231 cell lysate at 40 µg

Lane 2:

Mouse kidney tissue lysate at 40 µg

Predicted band size: 65 kDa

false

Exposure time: 20s

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human Choline dehydrogenase, mitochondrial. The exact immunogen used to generate this antibody is proprietary information.

Q8NE62

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보완 제품

Primary Antibodies

AB88053

Anti-Choline kinase alpha antibody

Immunocytochemistry/ Immunofluorescence - Anti-Choline kinase alpha antibody (AB88053)

  • 5
  • 3
Primary Antibodies

AB316329

Anti-SHMT2/SHMT antibody [EPR28607-51] - BSA and Azide free

BOND RX™ Validated|Recombinant|RabMAb|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SHMT2/SHMT antibody [EPR28607-51] - BSA and Azide free (AB316329)

  • 0
  • 0
Primary Antibodies

AB81286

Anti-MMP8 antibody [EP1252Y]

RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MMP8 antibody [EP1252Y] (AB81286)

  • 4
  • 5
Primary Antibodies

AB108323

Anti-Perilipin 2 antibody [EPR3713]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-Perilipin 2 antibody [EPR3713] (AB108323)

  • 4
  • 3
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/25 - 1/100", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CHDH also known as choline dehydrogenase functions mechanically as an enzyme that plays an important role in choline metabolism. This enzyme exhibits a molecular mass of approximately 61 kDa. It catalyzes the oxidation of choline to betaine aldehyde converting it further to glycine betaine which influences osmotic stress adaptation. CHDH shows strong expression in kidney and liver tissues indicating its role in these organs.
Biological function summary

The process facilitated by CHDH is essential for synthesizing glycine betaine a critical osmolyte that helps cells combat osmotic stress by stabilizing proteins and cell membranes. CHDH does not operate within a complex but is involved directly as a part of individual reactions leading to glycine betaine formation. This biological function supports cellular tolerance to high salinity and dehydration conditions.

Pathways

Choline metabolism and glycine serine and threonine metabolism involve CHDH as a significant component. Choline metabolism intimately connects with one-carbon metabolism where nutrients like folate integrate through various conversions. Within these pathways CHDH interacts closely with betaine-aldehyde dehydrogenase another enzyme that completes the conversion of choline into glycine betaine.

CHDH associates with conditions such as prostate cancer and liver disease. Aberrant expression or mutations in CHDH can contribute to an imbalance in osmoprotectant levels affecting cellular function. Its association with the folate cycle also links it to homocysteine levels where disruptions might result in increased risk for cardiovascular disease interacting indirectly with proteins like methylene tetrahydrofolate reductase (MTHFR) which influences homocysteine metabolism.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

See full target information Choline dehydrogenase, mitochondrial
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Molecular medicine reports 22:2263-2272 PubMed32705251

2020

Shikonin inhibits CEBPD downregulation in IL‑17‑treated HaCaT cells and in an imiquimod‑induced psoriasis model.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Ou Lan,He-Xiao Wang,Rui-Qun Qi,Yuan-Yuan Xu,Ya-Jie Yu,Yang Yang,Hao Guo,Xing-Hua Gao,Long Geng
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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