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AB134713

Anti-Cholecystokinin antibody

1

(1 리뷰)

|

(2 제품이 사용된 논문 )

Rabbit Polyclonal Cholecystokinin antibody. Suitable for IHC-P and reacts with Human samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human Cholecystokinin.

대체 명칭 보기

Cholecystokinin, CCK

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cholecystokinin antibody (AB134713)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Cholecystokinin antibody (AB134713)

Immunohistochemical analysis of paraffin-embedded Human brain tissue labelling Cholecystokinin with ab134713 at 1/50 dilution.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P

applications

Immunogen

Synthetic Peptide within Human Cholecystokinin. The exact immunogen used to generate this antibody is proprietary information.

P06307

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50 - 1/100", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
ab134713 was affinity-purified from Rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
보관 버퍼
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Cholecystokinin often referenced as CCK is a peptide hormone with a mass of approximately 8 kDa. It plays a mechanical role by being released from the I-cells in the small intestine particularly the duodenum. This release occurs in response to nutrients in the gut such as fats and proteins. Cholecystokinin acts by binding to its receptors CCK-A and CCK-B to execute its functions. In addition to the gut CCK is expressed in the central nervous system where it contributes to diverse neurological functions.
Biological function summary

Beyond its presence in the digestive system cholecystokinin is important for stimulating digestive enzymes secretion from the pancreas and bile release from the gallbladder. This peptide is also part of the central nervous system where it influences appetite control satiety and anxiety regulation. While not part of a classic protein complex CCK interacts with various receptors and enzymes to perform its roles in these physiological processes.

Pathways

Several important physiological pathways include cholecystokinin to regulate digestive processes and satiety signals. It is significant in the digestion pathway interacting chiefly with proteins such as trypsinogen and pancreatic lipase enhancing the breakdown of nutrients. In the neural pathway CCK influences neurotransmitter release including dopamine and serotonin highlighting its role in appetite suppression and mood regulation.

Cholecystokinin has been implicated in gastrointestinal and neurological conditions. It links to gallstone disease by influencing bile composition and flow which can affect the development of gallstones. Additionally CCK has connections to anxiety disorders given its impact on neurotransmitter systems within the brain. The peptide's engagement with CCK receptors makes it a target for studying these disorders as alterations in its signaling can contribute to disease pathology.

제품 프로토콜

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타겟 정보

This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear. Binding to CCK-A receptors stimulates amylase release from the pancreas, binding to CCK-B receptors stimulates gastric acid secretion.
See full target information Cholecystokinin

제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Endocrine pathology 36:23 PubMed40553402

2025

Extended Hormone Profiling Identifies a Wider Network of Duodenal Neuroendocrine Tumor Subtypes.

Applications

Unspecified application

Species

Unspecified reactive species

Luvy Delfin,Shereen Ezzat,Sylvia L Asa

PloS one 10:e0132366 PubMed26177381

2015

Alterations in Brain Inflammation, Synaptic Proteins, and Adult Hippocampal Neurogenesis during Epileptogenesis in Mice Lacking Synapsin2.

Applications

Unspecified application

Species

Unspecified reactive species

Deepti Chugh,Idrish Ali,Anahita Bakochi,Elma Bahonjic,Lars Etholm,Christine T Ekdahl
제품이 사용된 논문 모두 보기

Product promise

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