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AB222300

Anti-Claudin 9 antibody

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(1 출판물)

Rabbit Polyclonal Claudin 9 antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human Claudin 9 aa 150 to C-terminus.

대체 명칭 보기

Claudin-9, CLDN9

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-Claudin 9 antibody (AB222300)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-Claudin 9 antibody (AB222300)

PFA-fixed, Triton X-100 permeabilized MCF7 (human breast adenocarcinoma cell line) cells stained for Claudin 9 (green) using ab222300 at 4 μg/ml in ICC/IF.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human Claudin 9 aa 150 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

O95484

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대체품

Primary Antibodies

AB192398

Anti-Claudin 9 antibody

Western blot - Anti-Claudin 9 antibody (AB192398)

  • 5
  • 1
Primary Antibodies

AB187116

Anti-Claudin 9 antibody [YD4E9] - BSA and Azide free

Flow Cytometry - Anti-Claudin 9 antibody [YD4E9] - BSA and Azide free (AB187116)

  • 5
  • 1

보완 제품

Primary Antibodies

AB218106

Anti-uPA Receptor/U-PAR antibody [EPR20191]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-uPA Receptor/U-PAR antibody [EPR20191] (AB218106)

  • 0
  • 0
Primary Antibodies

AB214487

Anti-Claudin 3 antibody [EPR19971]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Claudin 3 antibody [EPR19971] (AB214487)

  • 4
  • 3
Primary Antibodies

AB235909

Anti-ApoER2 antibody

Immunocytochemistry/ Immunofluorescence - Anti-ApoER2 antibody (AB235909)

  • 0
  • 0
Primary Antibodies

AB314134

Anti-Claudin 6 antibody [EPR28103-113]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Claudin 6 antibody [EPR28103-113] (AB314134)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

Claudin-9 also known as CLDN9 is a member of the claudin protein family. This protein plays an important role in forming tight junctions which are responsible for regulating paracellular permeability in epithelial and endothelial cell sheets. Claudin-9 has a predicted mass of approximately 23 kDa. It is primarily expressed in the inner ear specifically in the cochlea and has vital functions in maintaining the permeability barrier and the structural integrity of cell layers.
Biological function summary

Claudin-9 engages in maintaining the tight junction barrier function of epithelial cells. It operates within a complex interacting closely with other claudin family members to establish the selective paracellular barrier important for ion balance and cellular homeostasis. These interactions allow claudin-9 to contribute significantly to the physiology of tissues where it is expressed impacting hearing function through ion permeability regulation in the cochlear epithelium.

Pathways

Claudin-9 is an integral component of pathways involved in cell-to-cell adhesion and cell polarity maintenance. It participates prominently in the tight junction pathway which is tightly regulated for maintaining the fundamental structure of epithelial layers. In this context it works alongside related proteins such as occludin and certain zonula occludens proteins which fortify the overall structure and signaling pathways essential for epithelial cell function.

Mutations or dysregulation of claudin-9 have been implicated in particular hearing impairments. Sensorineural hearing loss a condition attributed to malfunction in the inner ear's sensory parts aligns with malfunctions in claudin-9 activity. This condition can also have connections to other proteins involved in cochlear biology such as K+ channel proteins indicating how disruptions in tight junction function can affect ion homeostasis and lead to auditory dysfunction.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.. (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) entry into hepatic cells.
See full target information Claudin 9
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Arteriosclerosis, thrombosis, and vascular biology 33:1435-40 PubMed23520161

2013

Association of the thrombomodulin gene c.1418C>T polymorphism with thrombomodulin levels and with venous thrombosis risk.

Applications

Unspecified application

Species

Unspecified reactive species

Silvia Navarro,Pilar Medina,Elena Bonet,Javier Corral,Vicenta Martínez-Sales,Laura Martos,Miguel Rivera,Esther Roselló-Lletí,Ignacio Alberca,Vanessa Roldán,Yolanda Mira,Fernando Ferrando,Amparo Estellés,Vicente Vicente,Rogier M Bertina,Francisco España
제품이 사용된 논문 모두 보기
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Product promise

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