AB235434

Anti-CLYBL/CLB antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal CLYBL/CLB antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 2 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CLYBL.

대체 명칭 보기

CLB, CLYBL, (3S)-malyl-CoA thioesterase, Beta-methylmalate synthase, Citrate lyase subunit beta-like protein, Malate synthase, Citrate lyase beta-like

4 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLYBL/CLB antibody (AB235434)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLYBL/CLB antibody (AB235434)

Immunohistochemical analysis of paraffin-embedded human liver tissue labelling CLYBL/CLB with ab235434 at 1/50 dilution, followed by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.

Antigen retrieval was performed using high pressure in a citrate buffer (pH 6.0). The section was blocked with 10% normal goat serum for 30 mins at 37°C, before being incubated with the primary antibody at 4°C overnight.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLYBL/CLB antibody (AB235434)

Paraffin-embedded human liver tissue stained for CLYBL/CLB using ab235434 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLYBL/CLB antibody (AB235434)

Paraffin-embedded human rectum tissue stained for CLYBL/CLB using ab235434 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLYBL/CLB antibody (AB235434)

Paraffin-embedded human kidney tissue stained for CLYBL/CLB using ab235434 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CLYBL.

Q8N0X4

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/5000", "WB-species-notes": "", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

Purity >95%.

보관 버퍼

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Mitochondrial enzyme required to detoxify vitamin B12-poisoning metabolites (PubMed : 29056341, PubMed : 40108300). Acts as a citramalyl-CoA lyase by converting citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway, a pathway required to detoxify itaconate, a vitamin B12-poisoning metabolite (PubMed : 29056341). Also acts as a malyl-CoA thioesterase to detoxify malyl-CoA, a side product of citric acid cycle enzymes, which is toxic for the vitamin B12-dependent enzyme MMUT (PubMed : 40108300). Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate (PubMed : 24334609, PubMed : 29056341). Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate (PubMed : 24334609, PubMed : 29056341). Also has very weak citramalate synthase activity in vitro (PubMed : 24334609, PubMed : 29056341).

See full target information CLYBL

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of translational medicine 23:415 PubMed40211376

2025

Acetylation suppresses breast cancer progression by sustaining CLYBL stability.

Applications

Unspecified application

Species

Unspecified reactive species

Xinyue Deng,Chenglong Ma,Xingyu Chen,Ming Yi,Qianhua Cao,Ruocen Liao,Xingyu Lei,Longchang Bai,Bin Zhao,Yingnan Wang,Zhuoyang Shen,Liujing Wu,Chenfang Dong,Zhijun Dai

American journal of cancer research 14:1768-1783 PubMed38726285

2024

Roles of RNA mC modification patterns in prognosis and tumor microenvironment infiltration of diffuse large B-cell lymphoma.

Applications

Unspecified application

Species

Unspecified reactive species

Wenting Cui,Cancan Luo,Lili Zhou,Tiantian Yu,Yongsheng Meng,Qianqian Yu,Zhixiang Lei,Ya Wang,Lijuan Peng,Qingqing Luo,Duozhuang Tang,Ruifang Sun,Li Yu

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CLYBL/CLB antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLYBL/CLB antibody (AB235434)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLYBL/CLB antibody (AB235434)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLYBL/CLB antibody (AB235434)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CLYBL/CLB antibody (AB235434)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

제품 프로토콜

타겟 정보

제품이 사용된 논문 (2)

Product promise