AB198284

Anti-CMTM6 antibody - C-terminal

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(3 제품이 사용된 논문 )

Rabbit Polyclonal CMTM6 antibody. C-terminal. Suitable for IHC-P, WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Synthetic Peptide within Human CMTM6 aa 100 to C-terminus.

대체 명칭 보기

CKLFSF6, CMTM6, CKLF-like MARVEL transmembrane domain-containing protein 6, Chemokine-like factor superfamily member 6

2 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CMTM6 antibody - C-terminal (AB198284)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CMTM6 antibody - C-terminal (AB198284)

Immunohistochemical analysis of paraffin embedded human cervical cancer tissue labeling CMTM6 with ab198284 at 1/17 dilution.

Supplier Data

Western blot - Anti-CMTM6 antibody - C-terminal (AB198284)

10% SDS-PAGE

All lanes:

Western blot - Anti-CMTM6 antibody - C-terminal (ab198284) at 1/350 dilution

Lane 1:

Human placenta tissue lysate at 40 µg

Lane 2:

Human testis tissue lysate at 40 µg

Lane 3:

HeLa (Human epithelial cell line from cervix adenocarcinoma) cell lysate at 40 µg

Lane 4:

Raji (Human Burkitt's lymphoma cell line) cell lysate at 40 µg

Predicted band size: 20 kDa

false

Exposure time: 2min

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human CMTM6 aa 100 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q9NX76

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/100", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.4 Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its STUB1-mediated ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately triggering T-cell anergy.

See full target information CMTM6

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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cancer science 112:4064-4074 PubMed34251713

2021

Role of BCLAF-1 in PD-L1 stabilization in response to ionizing irradiation.

Applications

Unspecified application

Species

Unspecified reactive species

Zhao Ma,Han Wang,Fanbiao Meng,Yamei Han,Yefei Chen,Mingming Xiao,Hongjing Jiang,Zhentao Yu,Bo Xu

DNA and cell biology : PubMed33090010

2020

Expression and Clinical Significance of CMTM6 in Nonsmall Cell Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Xueyan Hou,Sisi He,Daquan Zhang,Chengli Yang,Yongli Shi,Kuanlin Zhang

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 14:2084-2096 PubMed31605795

2019

Quantitative Assessment of CMTM6 in the Tumor Microenvironment and Association with Response to PD-1 Pathway Blockade in Advanced-Stage Non-Small Cell Lung Cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Jon Zugazagoitia,Yuting Liu,Maria Toki,John McGuire,Fahad Shabbir Ahmed,Brian S Henick,Richa Gupta,Scott N Gettinger,Roy S Herbst,Kurt A Schalper,David L Rimm

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CMTM6 antibody - C-terminal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CMTM6 antibody - C-terminal (AB198284)

Western blot - Anti-CMTM6 antibody - C-terminal (AB198284)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

제품 프로토콜

타겟 정보

제품이 사용된 논문 (3)

Product promise