JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB235061

Anti-COPE antibody

Be the first to review this product! 리뷰 제출

|

(1 출판물)

Rabbit Polyclonal COPE antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human Coatomer subunit epsilon.

대체 명칭 보기

Coatomer subunit epsilon, Epsilon-coat protein, Epsilon-COP, COPE

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COPE antibody (AB235061)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COPE antibody (AB235061)

Paraffin-embedded prostate cancer tissue stained for COPE using ab235061 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human Coatomer subunit epsilon.

O14579

style
left-column

대체품

Primary Antibodies

AB180946

Anti-COPE antibody [EPR12579]

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-COPE antibody [EPR12579] (AB180946)

  • 0
  • 0

보완 제품

Primary Antibodies

AB229639

Anti-COPB2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COPB2 antibody (AB229639)

  • 0
  • 0
Primary Antibodies

AB124824

Anti-CXCR4 antibody [UMB2]

BOND RX™ Validated|RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CXCR4 antibody [UMB2] (AB124824)

  • 4
  • 17
Primary Antibodies

AB24233

Anti-MC4-R antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-MC4-R antibody (AB24233)

  • 4
  • 18
Primary Antibodies

AB2899

Anti-beta COP antibody

Immunocytochemistry/ Immunofluorescence - Anti-beta COP antibody (AB2899)

  • 5
  • 15
style
left-column

Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chinese hamster": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
style
left-column
style
left-column

특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity >95%
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
style
left-column

추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

The COPE protein also known as Coatomer Protein Complex Subunit E is a component of the COPI coatomer complex. This protein roughly weighs approximately 34 kDa and is present in the Golgi apparatus where it takes part in vesicle formation processes. COPE is expressed in numerous cell types highlighting its importance in intracellular transport mechanisms and maintaining cellular organization.
Biological function summary

COPE plays a significant role in the retrograde transport of proteins from the Golgi back to the endoplasmic reticulum being part of the larger COPI complex. The COPI coatomer complex operates in conjunction with other coat proteins like clathrin to ensure vesicle trafficking and membrane dynamics. This mechanism is essential for membrane recycling protein sorting and other cellular logistics.

Pathways

COPE is important in the secretory pathway. It interacts closely with other components like ARF1 a small GTPase that regulates coat assembly and disassembly to maintain efficient protein sorting. Moreover COPE's role intersects with the ER-to-Golgi transport pathway acting alongside proteins like Sec27 demonstrating its connection within a tightly regulated trafficking network essential for cellular function.

COPE's malfunction associates with neurodegenerative diseases. Disruption in its role in vesicular trafficking can lead to protein aggregation disorders like Alzheimer's disease where protein accumulation becomes pathogenic. COPE interaction with proteins such as APP (Amyloid Precursor Protein) becomes evident in the pathology of Alzheimer's showcasing its importance in disease progression.
style
left-column
style
left-column

제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

타겟 정보

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors (By similarity).
See full target information Coatomer subunit epsilon
style
left-column

제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Biochemical pharmacology 182:114216 PubMed32926875

2020

Antidiabetic drug therapy alleviates type 1 diabetes in mice by promoting pancreatic α-cell transdifferentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Dipak Sarnobat,Charlotte R Moffett,Neil Tanday,Frank Reimann,Fiona M Gribble,Peter R Flatt,Andrei I Tarasov
제품이 사용된 논문 모두 보기
style
left-column
style
left-column
style
right-column

Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com