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AB238911

Anti-COPT2 antibody

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Rabbit Polyclonal COPT2 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human SLC31A2 aa 1-100.

대체 명칭 보기

COPT2, CTR2, SLC31A2, Protein SLC31A2, Copper transporter 2, Solute carrier family 31 member 2, hCTR2

3 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COPT2 antibody (AB238911)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COPT2 antibody (AB238911)

Paraffin-embedded human gastric cancer tissue stained for COPT2 using ab238911 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COPT2 antibody (AB238911)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COPT2 antibody (AB238911)

Paraffin-embedded human prostate cancer tissue stained for COPT2 using ab238911 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-COPT2 antibody (AB238911)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-COPT2 antibody (AB238911)

HeLa (Human epithelial cell line from cervix adenocarcinoma) cells stained for COPT2 (Green) using ab238911 at 1/100 dilution in ICC/IF, followed by an Alexa-Fluor®488-conjugated Goat Anti-Rabbit IgG (H+L) secondary antibody.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

ICC/IF, IHC-P

applications

Immunogen

Recombinant Fragment Protein within Human SLC31A2 aa 1-100. The exact immunogen used to generate this antibody is proprietary information.

O15432

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보완 제품

Primary Antibodies

AB235306

Anti-TZFP/ZBTB32 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TZFP/ZBTB32 antibody (AB235306)

  • 0
  • 0
Primary Antibodies

AB234832

Anti-ZMPSTE24 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ZMPSTE24 antibody (AB234832)

  • 0
  • 0
Primary Antibodies

AB89117

Anti-SLC25A3/PHC antibody

Immunocytochemistry/ Immunofluorescence - Anti-SLC25A3/PHC antibody (AB89117)

  • 0
  • 0
Primary Antibodies

AB154193

Anti-Von Willebrand Factor antibody [EPSISR15]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Von Willebrand Factor antibody [EPSISR15] (AB154193)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity greater than 95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

COPT2 also known as COPTI or Copper Transporter 2 functions mechanically as a transporter protein responsible for moving copper ions across cell membranes. It facilitates the import of essential copper ions into the cells integral for various cellular processes. The mass of COPT2 is approximately 27 kilodaltons. It is mainly expressed in the liver kidneys and brain where cells demand efficient copper ion regulation.
Biological function summary

COPT2 plays an important role in maintaining copper homeostasis within the body allowing proper cellular functions that require copper-dependent enzymes. COPT2 is not part of a protein complex but its significance lies in its singular ability to enhance cellular uptake of copper ions. Copper-dependent enzymes such as cytochrome c oxidase and superoxide dismutase rely on COPT2's function to maintain optimal activity within the cell.

Pathways

COPT2 is directly involved in the copper regulation pathway ensuring that cells receive sufficient copper ions for enzymatic activities. This pathway also interacts with metallothioneins which are proteins responsible for metal detoxification and storage. COPT2's function complements other copper transport proteins like ATP7A and ATP7B which help in exporting and distributing copper within the body.

Disturbances in COPT2 function contribute to conditions such as Wilson's disease and Menkes disease. Wilson's disease results from copper accumulation due to impaired copper transport while Menkes disease involves defective copper absorption. COPT2 works alongside proteins like ATP7B in Wilson's disease and ATP7A in Menkes disease highlighting its important involvement in managing copper ion levels and maintaining cellular health.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Does not function as a copper(1+) importer in vivo (By similarity). However, in vitro functions as a low-affinity copper(1+) importer (PubMed : 17617060, PubMed : 17944601). Regulator of SLC31A1 which facilitates the cleavage of the SLC31A1 ecto-domain or which stabilizes the truncated form of SLC31A1 (Truncated CTR1 form), thereby drives the SLC31A1 truncated form-dependent endosomal copper export and modulates the copper and cisplatin accumulation via SLC31A1 (By similarity).
See full target information SLC31A2
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

International journal of biological sciences 20:1045-1063 PubMed38322121

2024

The homeoprotein HOXB2 limits triple-negative breast carcinogenesis via extracellular matrix remodeling.

Applications

Unspecified application

Species

Unspecified reactive species

Ji Hoon Oh,Clara Yuri Kim,Da Som Jeong,Yu Cheon Kim,Myoung Hee Kim,Je-Yoel Cho
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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