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AB126295

Anti-COQ4 antibody

2

(1 리뷰)

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(1 출판물)

Rabbit Polyclonal COQ4 antibody. Suitable for IHC-P, WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human COQ4 aa 100-200.

대체 명칭 보기

CGI-92, COQ4, 4-hydroxy-3-methoxy-5-polyprenylbenzoate decarboxylase, Coenzyme Q biosynthesis protein 4 homolog

5 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COQ4 antibody (AB126295)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COQ4 antibody (AB126295)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human duodenum tissue labelling COQ4 with ab126295 at 1/1000 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COQ4 antibody (AB126295)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COQ4 antibody (AB126295)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human skeletal muscle tissue labelling COQ4 with ab126295 at 1/1000 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COQ4 antibody (AB126295)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COQ4 antibody (AB126295)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human fallopian tube tissue labelling COQ4 with ab126295 at 1/1000 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COQ4 antibody (AB126295)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COQ4 antibody (AB126295)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human small intestine tissue labelling COQ4 with ab126295 at 1/1000 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COQ4 antibody (AB126295)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COQ4 antibody (AB126295)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human liver tissue labelling COQ4 with ab126295 at 1/1000 dilution. Heat mediated antigen retrieval performed with citrate buffer pH 6 before commencing with IHC staining protocol.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Fragment Protein within Human COQ4 aa 100-200. The exact immunogen used to generate this antibody is proprietary information.

Q9Y3A0

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보완 제품

Primary Antibodies

AB14734

Anti-VDAC1/Porin + VDAC3 antibody [20B12AF2] - Mitochondrial Loading Control

Lab Essentials|KO Validated

Western blot - Anti-VDAC1/Porin + VDAC3 antibody [20B12AF2] - Mitochondrial Loading Control (AB14734)

  • 5
  • 52
Primary Antibodies

AB181053

Anti-G-CSF antibody [EPR3203(N)(B)]

20ul selling size|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-G-CSF antibody [EPR3203(N)(B)] (AB181053)

  • 4
  • 1
Primary Antibodies

AB214039

Anti-Transferrin Receptor antibody [EPR20584]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Transferrin Receptor antibody [EPR20584] (AB214039)

  • 5
  • 1
Primary Antibodies

AB14730

Anti-ATPB antibody [3D5] - Mitochondrial Marker

Lab Essentials

Western blot - Anti-ATPB antibody [3D5] - Mitochondrial Marker (AB14730)

  • 5
  • 43
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/1000 - 1/2500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "0.04-0.4 µg/mL", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
보관 버퍼
pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

COQ4 also known as Coenzyme Q4 homologue is a protein that plays an important role in the biosynthesis of coenzyme Q10 (CoQ10) a vital component of the electron transport chain in mitochondria. COQ4 has a molecular mass of approximately 27.5 kDa. It is mainly expressed in tissues with high energy demands like the heart liver and skeletal muscle. COQ4 is important in maintaining mitochondrial function due to its involvement in the production of CoQ10.
Biological function summary

COQ4 associates with the mitochondrial inner membrane and forms part of the multi-subunit complex known as the CoQ biosynthesis complex. This complex is responsible for the stepwise synthesis of CoQ10 which acts as an electron carrier and antioxidant. By participating in this complex COQ4 contributes to cellular respiration and energy production. Its function ensures the stability and assembly of the complex highlighting its essential role in the biochemical pathway of CoQ10 biosynthesis.

Pathways

COQ4 is involved in the oxidative phosphorylation pathway critical for ATP production in eukaryotic cells. It interlinks with the mevalonate pathway as the biosynthesis of CoQ10 shares intermediates derived from this pathway. The protein also works in conjunction with other components of the CoQ biosynthesis complex including COQ3 COQ6 and COQ7 to fulfill its function in mitochondrial electron transport and energy metabolism.

COQ4 mutations and deficiencies have been linked to coenzyme Q10 deficiency syndromes and mitochondrial complex I deficiency. Such conditions can lead to a wide range of symptoms including encephalomyopathy myopathy and organ dysfunction. COQ4's malfunction affects energy production in cells particularly in tissues with high energy requirements. Its connection to other proteins in the CoQ10 biosynthesis pathway such as COQ2 and COQ9 further emphasizes its significance in maintaining cellular energy balance and preventing related disorders.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Lyase that catalyzes the C1-decarboxylation of 4-hydroxy-3-methoxy-5-(all-trans-decaprenyl)benzoic acid into 2-methoxy-6-(all-trans-decaprenyl)phenol during ubiquinone biosynthesis.
See full target information COQ4
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

PloS one 12:e0186247 PubMed29190290

2017

Skeletal muscle mitochondrial bioenergetics and associations with myostatin genotypes in the Thoroughbred horse.

Applications

Unspecified application

Species

Unspecified reactive species

Mary F Rooney,Richard K Porter,Lisa M Katz,Emmeline W Hill
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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