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AB68310

Anti-COSMC antibody

5

(3 리뷰들)

|

(1 출판물)

Mouse Polyclonal COSMC antibody. Carrier free. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human C1GALT1C1.
1 이미지
Western blot - Anti-COSMC antibody (AB68310)
  • WB

Unknown

Western blot - Anti-COSMC antibody (AB68310)

All lanes:

Western blot - Anti-COSMC antibody (ab68310) at 1/500 dilution

All lanes:

human liver tissue lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 36 kDa

Observed band size: 32 kDa

false

주요 정보

Host species

Mouse

Clonality

Polyclonal

Isotype

IgG

Carrier free

Yes

Reacts with

Human

Applications

WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human C1GALT1C1.

Q96EU7

Specificity

This antibody is reactive against mammalian transfected lysate.

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대체품

Primary Antibodies

AB229831

Anti-COSMC antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COSMC antibody (AB229831)

  • 0
  • 0

보완 제품

Primary Antibodies

AB124296

Anti-Ceramide glucosyltransferase antibody

Western blot - Anti-Ceramide glucosyltransferase antibody (AB124296)

  • 0
  • 0
Primary Antibodies

AB180578

Anti-MGAT1 antibody [EPR14247]

RabMAb|Recombinant|20ul selling size

Western blot - Anti-MGAT1 antibody [EPR14247] (AB180578)

  • 5
  • 5
Primary Antibodies

AB237734

Anti-C1GALT1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-C1GALT1 antibody (AB237734)

  • 0
  • 0
Primary Antibodies

AB183497

Anti-VSV-G tag antibody [EPR12997]

RabMAb|Recombinant|Lab Essentials

Western blot - Anti-VSV-G tag antibody [EPR12997] (AB183497)

  • 4
  • 2
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
보관 버퍼
pH: 7.4 Constituents: PBS
배송 시 보관 조건
Blue Ice
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

COSMC also known as "core 1 β3-Gal-T-specific molecular chaperone" is a molecular chaperone that plays a significant role in the proper formation of glycoproteins. It has a mass of approximately 55 kDa and is primarily expressed in the endoplasmic reticulum (ER). COSMC assists in ensuring the stability and activity of the T-synthase enzyme which is important for the O-glycosylation process in cells.
Biological function summary

This target ensures accurate glycan biosynthesis by acting as a proper folding assistant for its enzyme partner T-synthase. As part of this functional duo COSMC does not operate alone but facilitates a complex where proper protein folding and expression are necessary. Without COSMC's guidance T-synthase becomes inactive resulting in improper glycosylation patterns that can affect cellular functionality and communication.

Pathways

COSMC-related activities are important in the O-glycan biosynthesis pathway which is important for the production of mucins and other glycoproteins involved in cell signaling and adhesion. This chaperone also interacts with proteins in the Golgi apparatus where it supports the biosynthetic pathway of type 1 and type 2 core structures. COSMC's interaction ensures accurate protein glycosylation which impacts several cellular processes.

Faulty COSMC function is linked to Tn syndrome where improper glycan synthesis leads to an accumulation of specific glycoprotein types that can disrupt normal cellular behavior. Aberrant glycan structures resulting from COSMC mutations also connect it to cancer progression as it relates to altered cell surface antigens. This protein's function or malfunction within these contexts highlights the potential connections with other proteins such as T-synthase in glycan-related diseases.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Probable chaperone required for the generation of 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins. Probably acts as a specific molecular chaperone assisting the folding/stability of core 1 beta-3-galactosyltransferase (C1GALT1).
See full target information C1GALT1C1

대체 명칭 보기

COSMC, HSPC067, MSTP143, UNQ273/PRO310, C1GALT1C1, C1GALT1-specific chaperone 1, C38H2-like protein 1, Core 1 beta3-galactosyltransferase-specific molecular chaperone, C38H2-L1, C1Gal-T2, C1GalT2, Core 1 beta3-Gal-T2
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in molecular neuroscience 15:881571 PubMed35592111

2022

Contributes to the Regulation of Developmental Myelination in the Central Nervous System.

Applications

Unspecified application

Species

Unspecified reactive species

Jenica Acheta,Jiayue Hong,Haley Jeanette,Simrandeep Brar,Anish Yalamanchili,M Laura Feltri,M Chiara Manzini,Sophie Belin,Yannick Poitelon
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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