AB131143

Anti-COX7A2 antibody

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(2 제품이 사용된 논문 )

Rabbit Polyclonal COX7A2 antibody. Suitable for IHC-P, WB and reacts with Human, Rat samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human COX7A2.

대체 명칭 보기

COX7AL, COX7A2, Cytochrome c oxidase subunit VIIa-liver/heart, Cytochrome c oxidase subunit VIIa-L, Cytochrome c oxidase subunit VIIaL

2 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COX7A2 antibody (AB131143)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COX7A2 antibody (AB131143)

Immunohistochemical analysis of paraffin-embedded Human heart tissue labelling COX7A2 with ab131143 at 1/50 dilution.

Unknown

Western blot - Anti-COX7A2 antibody (AB131143)

All lanes:

Western blot - Anti-COX7A2 antibody (ab131143) at 1/500 dilution

Lane 1:

Rat heart cell extract

Lane 2:

Rat heart cell extract with immunising peptide

Predicted band size: 11 kDa,13 kDa,48 kDa,68 kDa,76 kDa,78 kDa,9 kDa

Observed band size: 45 kDa,68 kDa

false

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Rat, Human

Applications

WB, IHC-P

applications

Immunogen

Synthetic Peptide within Human COX7A2. The exact immunogen used to generate this antibody is proprietary information.

P14406

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/50", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.88% Sodium chloride

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

COX7A2 also known as cytochrome c oxidase subunit 7A2 is a component of the cytochrome c oxidase complex found in the inner mitochondrial membrane. This protein has an approximate molecular mass of 9.8 kDa. COX7A2 is expressed in various tissues with notable expression in highly metabolic tissues such as the heart and skeletal muscle. It plays a role in the electron transport chain by participating in the reduction of oxygen to water.

Biological function summary

COX7A2 contributes to the cytochrome c oxidase (complex IV) of the mitochondrial electron transport chain. This complex is important for ATP production through oxidative phosphorylation. COX7A2 forms part of the multi-subunit complex that facilitates efficient transfer of electrons which is essential for mitochondrial energy production. Its function in this complex underlines its importance in maintaining cellular respiration and energy homeostasis.

Pathways

COX7A2 plays an important role in the mitochondrial oxidative phosphorylation pathway. This pathway is essential for ATP production in eukaryotic cells. Another significant pathway involving COX7A2 is the respiratory electron transport pathway. Within these pathways COX7A2 interacts with other cytochrome c oxidase subunits like COX4 and COX5A which help regulate electron transfer and influence overall metabolic activity.

COX7A2 alterations and dysfunctions have been associated with mitochondrial disorders and myopathies. These disorders are often characterized by impaired energy metabolism due to defective oxidative phosphorylation. Within this context changes in COX7A2 expression can influence the functions of other cytochrome c oxidase subunits potentially affecting mitochondrial function and contributing to the pathological state of diseases like mitochondrial encephalomyopathy.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.

See full target information COX7A2

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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Functional & integrative genomics 25:90 PubMed40240625

2025

Identification and mechanistic analysis of shared biomarkers and pathogenesis in acute pancreatitis and sepsis based on differential gene expression and protein interaction networks.

Applications

Unspecified application

Species

Unspecified reactive species

Weina Lu,Yifeng Mao,Shangwen Cai,Qingqing Chen,Panpan Xu,Chenghua Xu,Cheng Zheng,Jian Lan

Glia 73:140-158 PubMed39392208

2024

The role of oligodendrocyte progenitor cells in the spatiotemporal vascularization of the human and mouse neocortex.

Applications

Unspecified application

Species

Unspecified reactive species

Kaiyi Liu,Zhiruo Kang,Min Yang,Fangbing Chen,Mingyang Xia,Wenjuan Dai,Shiyi Zheng,Huiyao Chen,Q Richard Lu,Wenhao Zhou,Yifeng Lin

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-COX7A2 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-COX7A2 antibody (AB131143)

Western blot - Anti-COX7A2 antibody (AB131143)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (2)

Product promise