AB243696

Anti-CP110 antibody

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(4 제품이 사용된 논문 )

Rabbit Polyclonal CP110 antibody. Suitable for IHC-P, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Recombinant Fragment Protein within Human CCP110 aa 250-450.

대체 명칭 보기

CEP110, CP110, KIAA0419, CCP110, Centriolar coiled-coil protein of 110 kDa, Centrosomal protein of 110 kDa, Cep110

5 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CP110 antibody (AB243696)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CP110 antibody (AB243696)

Negative control :

Formalin-fixed, paraffin-embedded human skeletal muscle tissue stained for CP110 using ab243696 at 1/200 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CP110 antibody (AB243696)

Formalin-fixed, paraffin-embedded human placenta tissue stained for CP110 using ab243696 at 1/200 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-CP110 antibody (AB243696)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-CP110 antibody (AB243696)

Paraformaldehyde-fixed, Triton X-100 permeabilized U-251 MG (human brain glioma cell line) cells labeling CP110 (Green) with ab243696 at 4 μg/mL in ICC/IF analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CP110 antibody (AB243696)

Formalin-fixed, paraffin-embedded human kidney tissue stained for CP110 using ab243696 at 1/200 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CP110 antibody (AB243696)

Formalin-fixed, paraffin-embedded human testis tissue stained for CP110 using ab243696 at 1/200 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Human

Applications

IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human CCP110 aa 250-450. The exact immunogen used to generate this antibody is proprietary information.

O43303

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p>Fixation/Permeabilization: PFA/Triton X-100.</p>" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Immunogen

보관 버퍼

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CP110 also known as centrosomal protein 110 is a critical component involved in centriole duplication spindle pole organization and ciliogenesis. It has a molecular weight of approximately 110 kDa. This protein is expressed in various tissues but shows higher expression in those with active cell division cycles such as embryonic tissues and cancer cell lines. As a centrosomal protein CP110 localizes to the centrosome an important cellular structure that manages microtubule organization and cell cycle progression.

Biological function summary

CP110 interacts with several other proteins to regulate centrosome function and cell division. It is a part of the centriole duplication complex which is essential for proper ciliogenesis and cell cycle control. CP110 caps the mother centriole and prevents the formation of cilia when the cell is in a dividing state therefore playing a role in the balance between cell division and the formation of cilia which contribute to cellular signaling and sensory functions.

Pathways

The centriole duplication and ciliogenesis processes involve CP110 as it interacts with pathways such as the cell cycle and the Sonic Hedgehog signaling pathway. CP110 partners with proteins like CEP97 and CEP290 to manage the length of centrioles and assist in the timely progression of the cell cycle. The regulation by CP110 ensures that centrosome duplication happens correctly preventing errors that might lead to cell division abnormalities.

CP110 has connections to ciliopathies and cancer. In ciliopathies where cilia formation is compromised impaired CP110 regulation can lead to disorders like Bardet-Biedl syndrome. In cancer overexpression or misregulation of CP110 may result in aberrant cell division and tumorigenesis. Another protein Cyclin-dependent kinase 2 (CDK2) plays a role in cell cycle regulation and works closely with CP110 indicating that disturbances in this interaction could also contribute to these diseases.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Necessary for centrosome duplication at different stages of procentriole formation. Acts as a key negative regulator of ciliogenesis in collaboration with CEP97 by capping the mother centriole thereby preventing cilia formation (PubMed : 17681131, PubMed : 17719545, PubMed : 23486064, PubMed : 30375385, PubMed : 35301795). Also involved in promoting ciliogenesis. May play a role in the assembly of the mother centriole subdistal appendages (SDA) thereby effecting the fusion of recycling endosomes to basal bodies during cilia formation (By similarity). Required for correct spindle formation and has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CETN2 (PubMed : 16760425).

See full target information CCP110

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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Cell communication and signaling : CCS 22:348 PubMed38961488

2024

TonEBP inhibits ciliogenesis by controlling aurora kinase A and regulating centriolar satellite integrity.

Applications

Unspecified application

Species

Unspecified reactive species

Batchingis Chinbold,Hyug Moo Kwon,Raekil Park

Life science alliance 6: PubMed36384894

2022

GPER1 links estrogens to centrosome amplification and chromosomal instability in human colon cells.

Applications

Unspecified application

Species

Unspecified reactive species

Miriam Bühler,Jeanine Fahrländer,Alexander Sauter,Markus Becker,Elisa Wistorf,Matthias Steinfath,Ailine Stolz

Cells 10: PubMed34685691

2021

The SZT2 Interactome Unravels New Functions of the KICSTOR Complex.

Applications

Unspecified application

Species

Unspecified reactive species

Cecilia Cattelani,Dominik Lesiak,Gudrun Liebscher,Isabel I Singer,Taras Stasyk,Moritz H Wallnöfer,Alexander M Heberle,Corrado Corti,Michael W Hess,Kristian Pfaller,Marcel Kwiatkowski,Peter P Pramstaller,Andrew A Hicks,Kathrin Thedieck,Thomas Müller,Lukas A Huber,Mariana Eca Guimaraes de Araujo

Anesthesiology 121:79-88 PubMed24589481

2014

Disruption of hippocampal neuregulin 1-ErbB4 signaling contributes to the hippocampus-dependent cognitive impairment induced by isoflurane in aged mice.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Min Li,Fan Su,Mu-Huo Ji,Guang-Fen Zhang,Li-Li Qiu,Min Jia,Jun Gao,Zhongcong Xie,Jian-Jun Yang

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CP110 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CP110 antibody (AB243696)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CP110 antibody (AB243696)

Immunocytochemistry/ Immunofluorescence - Anti-CP110 antibody (AB243696)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CP110 antibody (AB243696)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CP110 antibody (AB243696)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (4)

Product promise