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AB237627

Anti-CPNE4 antibody

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Rabbit Polyclonal CPNE4 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Mouse, Rat, Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human CPNE4 aa 1 to C-terminus.

대체 명칭 보기

Copine-4, Copine IV, Copine-8, CPNE4

3 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CPNE4 antibody (AB237627)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CPNE4 antibody (AB237627)

Paraffin-embedded human brain tissue stained for CPNE4 using ab237627 at 1/100 dilution in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CPNE4 antibody (AB237627)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CPNE4 antibody (AB237627)

Paraffin-embedded human prostate tissue stained for CPNE4 using ab237627 at 1/100 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-CPNE4 antibody (AB237627)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-CPNE4 antibody (AB237627)

A549 (human lung carcinoma cell line) cells stained for CPNE4 (green) using ab237627 at 1/100 dilution in ICC/IF, followed by Alexa Fluor 488® conjugated Goat Anti-Rabbit IgG (H+L).

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse, Rat, Human

Applications

WB, IHC-P, ICC/IF

applications

Immunogen

Recombinant Fragment Protein within Human CPNE4 aa 1 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q96A23

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보완 제품

Primary Antibodies

AB93618

Anti-TRP 7 antibody [N64A/36]

Immunocytochemistry/ Immunofluorescence - Anti-TRP 7 antibody [N64A/36] (AB93618)

  • 0
  • 0
Primary Antibodies

AB122400

Anti-NEURL1B antibody

Immunocytochemistry/ Immunofluorescence - Anti-NEURL1B antibody (AB122400)

  • 4
  • 1
Primary Antibodies

AB185102

Anti-TBC1D2B antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-TBC1D2B antibody (AB185102)

  • 0
  • 0
Primary Antibodies

AB167678

Anti-UMOD antibody

Immunocytochemistry/ Immunofluorescence - Anti-UMOD antibody (AB167678)

  • 1
  • 1
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/50 - 1/200", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/5000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "guaranteed", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Protein G
Purification 관련 사항
Purity greater than 95%.
보관 버퍼
pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CPNE4 also known as Copine-4 is a calcium-dependent phospholipid-binding protein. It weighs approximately 66 kDa and plays a role in cellular mechanisms by mediating membrane trafficking processes. CPNE4 is expressed in various tissues with significant presence in the brain indicating its potential role in neurological functions. It acts as a binding partner interacting with phospholipids in a calcium-dependent manner contributing to intra-cellular signaling and vesicle fusion.
Biological function summary

This protein assists in modulating membrane-associated processes and is believed to participate in synaptic plasticity because of its membrane-binding capabilities. CPNE4 could be part of molecular complexes involved in synaptic structuring and function. Evidence suggests it works in conjunction with other proteins involved in neuronal signaling though the exact complexes remain to be fully identified. Its role in membrane dynamics is essential for cellular communication and signaling.

Pathways

CPNE4 engages in pathways such as phosphatidylinositol signaling and synaptic vesicle transport. These pathways are important for ensuring proper neuronal communication and neurotransmitter release. CPNE4 interacts with various proteins within these pathways including kinases and synaptic proteins which together orchestrate complex signaling cascades. Its involvement in these pathways suggests it plays a part in regulating neuronal excitability and synaptic efficacy.

Researchers connect CPNE4 with neurodegenerative conditions and epilepsy due to its influence on synaptic function and brain tissue expression. Studies point to altered CPNE4 activity impacting neuronal stability potentially leading to the progression of such disorders. It may interact with proteins like tau in neurodegenerative diseases where tau pathology disrupts CPNE4-associated pathways exacerbating disease symptoms. Further understanding of CPNE4's role could prove essential in developing therapeutic strategies for these conditions.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.
See full target information CPNE4
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Nature neuroscience 24:19-23 PubMed33318667

2020

Microglial G-dependent dynamics regulate brain network hyperexcitability.

Applications

Unspecified application

Species

Unspecified reactive species

Mario Merlini,Victoria A Rafalski,Keran Ma,Keun-Young Kim,Eric A Bushong,Pamela E Rios Coronado,Zhaoqi Yan,Andrew S Mendiola,Elif G Sozmen,Jae Kyu Ryu,Matthias G Haberl,Matthew Madany,Daniel Naranjo Sampson,Mark A Petersen,Sophia Bardehle,Reshmi Tognatta,Terry Dean,Rosa Meza Acevedo,Belinda Cabriga,Reuben Thomas,Shaun R Coughlin,Mark H Ellisman,Jorge J Palop,Katerina Akassoglou
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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