AB235838

Anti-CRABP1 antibody

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(3 제품이 사용된 논문 )

Rabbit Polyclonal CRABP1 antibody. Suitable for WB, IHC-P and reacts with Mouse, Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CRABP1.

대체 명칭 보기

RBP5, CRABP1, Cellular retinoic acid-binding protein 1, Cellular retinoic acid-binding protein I, CRABP-I

2 이미지

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRABP1 antibody (AB235838)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRABP1 antibody (AB235838)

Paraffin-embedded human thyroid tissue stained for CRABP1 using ab235838 at 1/100 dilution in immunohistochemical analysis.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRABP1 antibody (AB235838)

Paraffin-embedded human breast cancer tissue stained for CRABP1 using ab235838 at 1/100 dilution in immunohistochemical analysis.

주요 정보

Host species

Rabbit

Clonality

Polyclonal

Isotype

IgG

Carrier free

Reacts with

Mouse, Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CRABP1.

P29762

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/20 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chicken": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein G

Purification 관련 사항

Purity >95%.

보관 버퍼

pH: 7.4 Preservative: 0.03% Proclin 300 Constituents: PBS, 50% Glycerol (glycerin, glycerine)

배송 시 보관 조건

Blue Ice

적절한 단기 보관 기간

1-2 weeks

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CRABP1 also known as Cellular Retinoic Acid Binding Protein 1 is a small protein with a molecular mass of around 15 kDa. It mainly binds and transports retinoic acid a metabolite of vitamin A that is important for cell growth and differentiation. CRABP1 is typically expressed in various tissues including the skin eyes and central nervous system. It provides cells with a way to regulate retinoic acid levels acting as a buffer and maintaining proper cellular functioning.

Biological function summary

CRABP1 plays a significant role in modulating the access of retinoic acid to nuclear receptors by controlling its availability in the cell. It is not part of a large protein complex but instead often acts independently to manage intracellular retinoic acid. The protein ensures normal development and maintenance of tissues by influencing gene transcription related to cell differentiation and proliferation. This regulation is important in processes like embryogenesis and skin regeneration.

Pathways

Several intricate signaling cascades involve CRABP1 such as the retinoic acid signaling pathway and the retinoid metabolic pathway. In these pathways CRABP1 directly interacts with proteins like Retinoic Acid Receptors (RARs) to modulate their activity. By regulating retinoic acid levels CRABP1 influences cellular response outcomes which is important for processes like morphogenesis and homeostasis.

CRABP1 has been linked to specific conditions like skin disorders and certain types of cancer. Altered levels of CRABP1 can impact the normal regulation of retinoic acid leading to dysfunctional cell proliferation and differentiation. The protein's interaction with RAR-related proteins plays a role in these diseases where disrupted signaling can result in anomalous cellular behavior contributing to pathological development.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors.

See full target information CRABP1

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제품이 사용된 논문 (3)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Carcinogenesis 46: PubMed40823720

2025

Core transcriptional regulatory circuit-regulated IGF2BP3 stabilizes E2F2 mRNA via m6A modification in neuroblastoma.

Applications

Unspecified application

Species

Unspecified reactive species

Pengcheng Yang,Jianwei Wang,Ziheng Wu,Ran Zhuo,Yanling Chen,Gen Li,Yanfang Tao,Xiaolu Li,Fang Fang,Di Wu,Yang Yang,Hongli Yin,Guanghui Qian,Hairong Wang,Xin Li,Juanjuan Yu,Randong Yang,Yunyun Xu,Zhiheng Li,Lei Shi,Zimu Zhang,Jian Pan,Jian Wang

Molecular carcinogenesis 62:1935-1946 PubMed37642311

2023

Downregulation of cellular retinoic acid binding protein 1 fosters epithelial-mesenchymal transition in thyroid cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Yi-Chiung Hsu,Wen-Chien Huang,Chi-Yu Kuo,Ying-Syuan Li,Shih-Ping Cheng

Frontiers in bioengineering and biotechnology 8:456 PubMed32500067

2020

Optimisation of a Novel Bio-Substrate as a Treatment for Atrophic Age-Related Macular Degeneration.

Applications

Unspecified application

Species

Unspecified reactive species

Rachel McCormick,Ian Pearce,Stephen Kaye,Atikah Haneef

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

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Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CRABP1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRABP1 antibody (AB235838)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRABP1 antibody (AB235838)

주요 정보

Host species

Clonality

Isotype

Carrier free

Reacts with

Applications

Immunogen

대체품

Primary Antibodies

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Assay Kits

Reactivity 정보

특성 및 보관 정보

제형

Purification 테크닉

Purification 관련 사항

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 기간

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

제품이 사용된 논문 (3)

Product promise