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AB236378

Anti-CRLF3 antibody [OTI2H3]

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Mouse Monoclonal CRLF3 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CRLF3.

대체 명칭 보기

CREME9, CRLM9, CYTOR4, P48, CRLF3, Cytokine receptor-like factor 3, Cytokine receptor-like molecule 9, Cytokine receptor-related protein 4, Type I cytokine receptor-like factor p48, CREME-9

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRLF3 antibody [OTI2H3] (AB236378)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CRLF3 antibody [OTI2H3] (AB236378)

Paraffin-embedded human spleen tissue stained for CRLF3 with ab236378 at a 1/500 dilution in immunohistochemical analysis.

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI2H3

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

IHC-P, WB

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CRLF3.

Q8IUI8

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보완 제품

Proteins & Peptides

AB162534

Recombinant Human CRLF3 protein (GST tag N-Terminus)

SDS-PAGE - Recombinant Human CRLF3 protein (GST tag N-Terminus) (AB162534)

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Primary Antibodies

AB155335

Anti-ROX antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ROX antibody (AB155335)

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Assay Kits

AB253778

Human GAPDH Antibody Pair - BSA and Azide free

RabMAb|Recombinant

Sandwich ELISA - Human GAPDH Antibody Pair - BSA and Azide free (AB253778)

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Primary Antibodies

AB307891

Anti-SUZ12 antibody [EPR26230-82]

BOND RX™ Validated|RabMAb|20ul selling size|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-SUZ12 antibody [EPR26230-82] (AB307891)

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/500", "IHCP-species-notes": "<p>Heat-induced epitope retrieval by 1 mM EDTA in 10 mM Tris buffer (pH 8.5) at 120°C for 3 minutes.</p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
Purification 관련 사항
Purified from cell culture supernatant.
보관 버퍼
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CRLF3 also known as Cytokine Receptor-Like Factor 3 is a protein that acts within the cytokine receptor family. This target is involved in transmitting signals through the cell membrane. CRLF3 has a mass of approximately 50 kDa. Expression of CRLF3 occurs in a variety of tissues indicating its widespread role in cellular communication. The receptor plays a role in cytokine signaling which influences immune responses and cellular growth processes.
Biological function summary

CRLF3 contributes significantly to immune system function and neurodevelopment. It participates in forming receptor complexes necessary for signal transduction impacting various physiological processes. Studies have shown that CRLF3 participates in neuroimmune pathways linking neural and immune system activities. Researchers often explore its mechanism alongside related receptors such as those in the interleukin receptor family to fully understand its broad biological impact.

Pathways

Cytokine signaling pathways prominently involve CRLF3. Particularly it is part of the JAK-STAT signaling pathway which is important for mediating responses to various cytokines and growth factors. CRLF3 interacts with other signaling proteins including JAK kinases and STAT transcription factors to relay signals from external stimuli to the cell's interior influencing gene expression and affecting cellular responses.

Scientists have recognized connections between CRLF3 and neurological disorders. Research indicates that altered CRLF3 function may contribute to diseases such as multiple sclerosis and epilepsy. Furthermore its interaction with proteins relevant to immune response and neural signaling suggests potential roles in these conditions. Understanding CRLF3's involvement in these disorders could offer valuable insights into possible therapeutic strategies.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

May play a role in the negative regulation of cell cycle progression.
See full target information CRLF3
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of translational medicine 23:805 PubMed40682116

2025

Sinensetin serves as an AMPK activator to inhibit RANKL-induced osteoclastogenesis via osteoclast cytoskeleton reorganization.

Applications

Unspecified application

Species

Unspecified reactive species

Yijie Gao,Rui Zhou,Xixi Lin,Zhijuan Liu,Yuangang Su,Haoyu Lian,Bin Lin,Xiaofei Ding,Shijie Liao,Xiangde Li,Jinmin Zhao,Jiake Xu,Ren Xu,Qian Liu,Fangming Song
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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