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AB236379

Anti-CTDSP2 antibody [OTI7F5]

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Mouse Monoclonal CTDSP2 antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human CTDSP2.

대체 명칭 보기

NIF2, OS4, SCP2, CTDSP2, Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2, Nuclear LIM interactor-interacting factor 2, Protein OS-4, Small C-terminal domain phosphatase 2, Small CTD phosphatase 2, NLI-interacting factor 2

1 이미지
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CTDSP2 antibody [OTI7F5] (AB236379)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CTDSP2 antibody [OTI7F5] (AB236379)

Paraffin-embedded human ovary adenocarcinoma tissue stained for CTDSP2 with ab236379 at a 1/150 dilution in immunohistochemical analysis.

주요 정보

Host species

Mouse

Clonality

Monoclonal

Clone number

OTI7F5

Isotype

IgG1

Carrier free

No

Reacts with

Human

Applications

WB, IHC-P

applications

Immunogen

Recombinant Full Length Protein corresponding to Human CTDSP2.

O14595

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보완 제품

Primary Antibodies

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Anti-SA1 antibody [EPR26227-76]

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  • 0
  • 0
Primary Antibodies

AB133497

Anti-Flotillin 1 antibody [EPR6041]

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Primary Antibodies

AB134045

Anti-CD63 antibody [EPR5702] - Late Endosome Marker

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD63 antibody [EPR5702] - Late Endosome Marker (AB134045)

  • 3
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Primary Antibodies

AB275377

Anti-ALIX antibody [EPR23653-32]

20ul selling size|RabMAb|Recombinant|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-ALIX antibody [EPR23653-32] (AB275377)

  • 5
  • 2
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/150", "IHCP-species-notes": "<p>Heat-induced epitope retrieval by 1 mM EDTA in 10 mM Tris buffer (pH 8.5) at 120°C for 3 minutes.</p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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제품 세부 정보

Clone OTI7F5 (formerly 7F5).
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification
Purification 관련 사항
Purified from cell culture supernatant.
보관 버퍼
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 1% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CTDSP2 also known as CTD Small Phosphatase 2 plays a role in regulating transcription processes by dephosphorylating the C-terminal domain of RNA polymerase II. This protein has a molecular mass around 33 kDa and is expressed in various tissues including the brain and testis. It possesses phosphoserine and phosphothreonine phosphatase activity which is central to its mechanical function in controlling transcriptional elongation and processing.
Biological function summary

CTDSP2 acts by modulating transcription elongation and RNA processing. It forms part of a complex involving other CTD phosphatases ensuring precise regulation of RNA polymerase II activity. This function implies that CTDSP2 participates in managing the transcription cycle and impacts RNA synthesis critical for gene expression and cellular function.

Pathways

CTDSP2 connects to the RNA polymerase II transcription cycle specifically affecting the transcriptional regulation pathway. It functions alongside associated phosphatases like CTDSP1 and CTDSP3 orchestrating the phosphorylation state of RNA polymerase II. These interactions highlight CTDSP2's integration in the fine-tuning of RNA synthesis impacting gene expression fidelity and cellular responses.

Aberrant activity of CTDSP2 associates with neurodegenerative diseases and cancer. Dysregulation in its expression or function often disrupts cellular transcription equilibrium connecting to proteins such as p53 in cancer pathways where it might influence tumor suppressor activities. Similarly CTDSP2 can impact neurodegenerative diseases through pathways involving amyloid precursor proteins showcasing its implication in brain functionality and pathology.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residue repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells. May contribute to the development of sarcomas.
See full target information CTDSP2
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제품이 사용된 논문 (1)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Journal of translational medicine 23:805 PubMed40682116

2025

Sinensetin serves as an AMPK activator to inhibit RANKL-induced osteoclastogenesis via osteoclast cytoskeleton reorganization.

Applications

Unspecified application

Species

Unspecified reactive species

Yijie Gao,Rui Zhou,Xixi Lin,Zhijuan Liu,Yuangang Su,Haoyu Lian,Bin Lin,Xiaofei Ding,Shijie Liao,Xiangde Li,Jinmin Zhao,Jiake Xu,Ren Xu,Qian Liu,Fangming Song
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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