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AB238246

Anti-CTGF antibody - C-terminal

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(2 제품이 사용된 논문 )

Goat Polyclonal CTGF antibody. C-terminal. Suitable for ICC/IF and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Human CCN2 aa 300 to C-terminus.

대체 명칭 보기

CTGF, HCS24, IGFBP8, CCN2, CCN family member 2, Cellular communication network factor 2, Connective tissue growth factor, Hypertrophic chondrocyte-specific protein 24, Insulin-like growth factor-binding protein 8, IBP-8, IGF-binding protein 8, IGFBP-8

1 이미지
Immunocytochemistry/ Immunofluorescence - Anti-CTGF antibody - C-terminal (AB238246)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-CTGF antibody - C-terminal (AB238246)

Immunofluorescent analysis of paraformaldehyde-fixed NIH/3T3 (mouse embryo fibroblast cell line) cells, permeabilized with 0.15% Triton, labeling CTGF with ab238246 at 5 μg/ml. Primary incubation time 1 hour followed by an Alexa-Fluor®488 secondary antibody (2 μg/ml). The nuclear stain is DAPI (blue).

Negative control : Non-immunized goat IgG (5 μg/ml) followed by an Alexa-Fluor®488 secondary antibody (2 μg/ml).

주요 정보

Host species

Goat

Clonality

Polyclonal

Isotype

IgG

Carrier free

No

Reacts with

Mouse

Applications

ICC/IF

applications

Immunogen

Synthetic Peptide within Human CCN2 aa 300 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

P29279

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대체품

Primary Antibodies

AB227180

Anti-CTGF antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CTGF antibody (AB227180)

  • 4
  • 1
Primary Antibodies

AB125943

Anti-CTGF antibody

BOND RX™ Validated

Immunocytochemistry/ Immunofluorescence - Anti-CTGF antibody (AB125943)

  • 0
  • 0
Primary Antibodies

AB6992

Anti-CTGF antibody

Immunohistochemistry (Frozen sections) - Anti-CTGF antibody (AB6992)

  • 4
  • 29
Primary Antibodies

AB209780

Anti-CTGF antibody [EPR20728]

20ul selling size|KO Validated|RabMAb|Recombinant

Immunoprecipitation - Anti-CTGF antibody [EPR20728] (AB209780)

  • 0
  • 0
Primary Antibodies

AB231824

Anti-CTGF antibody [EPR20728] - BSA and Azide free

KO Validated|RabMAb|Recombinant

Immunoprecipitation - Anti-CTGF antibody [EPR20728] - BSA and Azide free (AB231824)

  • 0
  • 0
Primary Antibodies

AB5097

Anti-CTGF antibody

Immunocytochemistry - Anti-CTGF antibody (AB5097)

  • 4
  • 8

보완 제품

Assay Kits

AB261851

Human CTGF ELISA kit

Recombinant|SimpleStep

ELISA - Human CTGF ELISA kit (AB261851)

  • 0
  • 0
Primary Antibodies

AB308463

Anti-CPLX3 antibody [EPR28433-43]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|Advanced Validation

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CPLX3 antibody [EPR28433-43] (AB308463)

  • 0
  • 0
Primary Antibodies

AB284387

Anti-BMP2 antibody [EPR24209-61]

20ul selling size|RabMAb|Recombinant

Flow Cytometry (Intracellular) - Anti-BMP2 antibody [EPR24209-61] (AB284387)

  • 0
  • 0
Primary Antibodies

AB228592

Anti-CYR61/CCN1 antibody

Immunocytochemistry/ Immunofluorescence - Anti-CYR61/CCN1 antibody (AB228592)

  • 0
  • 0
Primary Antibodies

AB252979

Anti-GDF6 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GDF6 antibody (AB252979)

  • 0
  • 0
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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "5 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Pig": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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특성 및 보관 정보

제형
Liquid
Purification 테크닉
Affinity purification Immunogen
Purification 관련 사항
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
보관 버퍼
pH: 7.3 Preservative: 0.02% Sodium azide Constituents: Tris buffered saline, 0.5% BSA
배송 시 보관 조건
Blue Ice
적절한 단기 보관 기간
1-2 weeks
적절한 단기 보관 조건
+4°C
적절한 장기 보관 조건
-20°C
분주 정보
Upon delivery aliquot
보관 정보
Avoid freeze / thaw cycle
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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CTGF also known as Connective Tissue Growth Factor is a significant protein in the CCN family involved in regulating various cellular functions. CTGF has a molecular weight of approximately 36-38 kDa. It is highly expressed in tissues such as the skin kidney and vascular tissues. This protein is secreted and can be found in the extracellular matrix where it interacts with other cellular components to mediate its effects.
Biological function summary

Connective Tissue Growth Factor plays an important role in cell adhesion proliferation and differentiation. It operates as an independent protein but can also be part of the extracellular matrix structure. CTGF functions as a mediator in the interaction between cells and their surrounding environment influencing processes such as angiogenesis and wound healing through these interactions.

Pathways

CTGF fits into the TGF-beta and Wnt signaling pathways where it helps modulate cellular responses to external stimuli. It interacts with proteins like fibronectin and integrins within these pathways enhancing cellular communication and response. These pathways are fundamental for both development and pathological conditions showing CTGF's influence on various biological processes.

CTGF shows a strong connection with fibrosis and cancer. In fibrotic conditions the CTGF protein interacts with collagen and fibronectin leading to excessive deposition in tissues. In cancers CTGF may promote tumor progression by facilitating angiogenesis and promoting invasive behaviors in tumors. These interactions highlight CTGF's role as a target for therapeutic strategies aimed at treating these diseases.
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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:
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타겟 정보

Major connective tissue mitoattractant secreted by vascular endothelial cells. Promotes proliferation and differentiation of chondrocytes. Is involved in the stimulation of osteoblast differentiation and has a critical role in osteogenesis (PubMed : 39414788). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells. Enhances fibroblast growth factor-induced DNA synthesis.
See full target information CCN2
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제품이 사용된 논문 (2)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Frontiers in immunology 14:1162669 PubMed37207208

2023

Naproxen chemoprevention induces proliferation of cytotoxic lymphocytes in Lynch Syndrome colorectal mucosa.

Applications

Unspecified application

Species

Unspecified reactive species

Charles M Bowen,Nan Deng,Laura Reyes-Uribe,Edwin Roger Parra,Pedro Rocha,Luisa M Solis,Ignacio I Wistuba,Valerie O Sepeda,Lana Vornik,Marjorie Perloff,Eva Szabo,Asad Umar,Krishna M Sinha,Powel H Brown,Eduardo Vilar

Frontiers in aging neuroscience 14:853320 PubMed35450058

2022

Age-Related Inflammation and Oxidative Stress in the Cochlea Are Exacerbated by Long-Term, Short-Duration Noise Stimulation.

Applications

Unspecified application

Species

Unspecified reactive species

Verónica Fuentes-Santamaría,Juan Carlos Alvarado,Susana Mellado,Pedro Melgar-Rojas,María Cruz Gabaldón-Ull,José J Cabanes-Sanchis,José M Juiz
제품이 사용된 논문 모두 보기
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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.
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