AB76015

Anti-CTNNA2 antibody [EPR1795]

Name: Anti-CTNNA2 antibody [EPR1795]
Brand: Abcam Limited
SKU: AB76015
Rating: 5 (1 reviews)

RabMAb
Recombinant
각 태그의 뜻

(1 리뷰)

(4 제품이 사용된 논문 )

Rabbit Recombinant Monoclonal CTNNA2 antibody. Suitable for WB and reacts with Mouse samples. Cited in 4 publications.

1 이미지

Unknown

Western blot - Anti-CTNNA2 antibody [EPR1795] (AB76015)

All lanes:

Western blot - Anti-CTNNA2 antibody [EPR1795] (ab76015) at 1/2000 dilution

All lanes:

mouse brain lysate at 10 µg

Secondary

All lanes:

Goat anti-rabbit HRP at 1/2000 dilution

Predicted band size: 105 kDa

Observed band size: 102 kDa

false

주요 정보

Host species

Rabbit

Clonality

Monoclonal

Clone number

EPR1795

Isotype

IgG

Carrier free

Reacts with

Mouse

Applications

applications

Immunogen

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity 정보

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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제품 세부 정보

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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특성 및 보관 정보

제형

Liquid

Purification 테크닉

Affinity purification Protein A

보관 버퍼

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

배송 시 보관 조건

Conditional Ambient

적절한 단기 보관 조건

+4°C

적절한 장기 보관 조건

-20°C

분주 정보

Upon delivery aliquot

보관 정보

Avoid freeze / thaw cycle

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추가 정보

This supplementary information is collated from multiple sources and compiled automatically.

CTNNA2 also known as alpha-N-catenin is a protein that plays a mechanical role in cellular adhesion. This protein has a mass of approximately 102 kDa. CTNNA2 localizes at adherens junctions and is expressed in various tissues with a high prominence in the nervous system. It connects the actin cytoskeleton to cadherin complexes facilitating cell-cell interactions that are essential for maintaining tissue integrity.

Biological function summary

CTNNA2 contributes significantly to cellular signaling and structural maintenance. It forms part of the cadherin-catenin complex important in linking cadherins to the actin cytoskeleton. This complex supports the stability and function of cellular junctions enabling communication between cells and influencing cell shape and polarity. The protein's role in the nervous system suggests its involvement in synaptic connectivity and plasticity.

Pathways

CTNNA2 participates in the Wnt signaling and the actin cytoskeleton regulation pathways. These pathways are vital for cellular growth differentiation and motility. In the Wnt signaling pathway CTNNA2 interacts with beta-catenin to regulate gene transcription and cell fate decisions. Its involvement in actin cytoskeleton regulation implicates it in coordination with actin filament dynamics sharing relations with actin-binding proteins like alpha-actinin.

CTNNA2 has connections with neurological disorders such as autism and intellectual disability. Alterations in its function or expression can disrupt neural development and synaptic function leading to cognitive impairments. Additionally CTNNA2 links to other proteins implicated in these conditions such as beta-catenin which is known to affect neural development and psychiatric conditions.

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제품 프로토콜

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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타겟 정보

May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system (By similarity). Required for proper regulation of cortical neuronal migration and neurite growth (PubMed : 30013181). It acts as a negative regulator of Arp2/3 complex activity and Arp2/3-mediated actin polymerization (PubMed : 30013181). It thereby suppresses excessive actin branching which would impair neurite growth and stability (PubMed : 30013181). Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity).

See full target information CTNNA2

대체 명칭 보기

CAPR, CTNNA2, Catenin alpha-2, Alpha N-catenin, Alpha-catenin-related protein

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제품이 사용된 논문 (4)

Recent publications for all applications. Explore the 전체 목록 and refine your search

Communications biology 8:1 PubMed39747445

2025

Fortilin binds CTNNA3 and protects it against phosphorylation, ubiquitination, and proteasomal degradation to guard cells against apoptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Mari Nakashima,Decha Pinkaew,Uttariya Pal,Fei Miyao,Hanna Huynh,Lena Tanaka,Ken Fujise

Journal of molecular endocrinology 64:43-52 PubMed31786540

2019

miR-183-5p regulates uterine receptivity and enhances embryo implantation.

Applications

Unspecified application

Species

Unspecified reactive species

Rubab Akbar,Kamran Ullah,Tanzil Ur Rahman,Yi Cheng,Hai-Yan Pang,Lu-Yang Jin,Qi-Jing Wang,He-Feng Huang,Jian-Zhong Sheng

DNA and cell biology 38:151-161 PubMed30526004

2018

Novel-miR-4885 Promotes Migration and Invasion of Esophageal Cancer Cells Through Targeting CTNNA2.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Song,Peng Zhang,Mengxin Liu,Ming Xie,Zhikui Gao,Xianghu Wang,Tian Wang,Jiechen Yin,Ran Liu

PloS one 8:e84354 PubMed24391944

2013

Impaired function of the blood-testis barrier during aging is preceded by a decline in cell adhesion proteins and GTPases.

Applications

Species

Rat

Catriona Paul,Bernard Robaire

제품이 사용된 논문 모두 보기

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Product promise

저희는 고품질 시약으로 고객님의 연구를 서포트하고자 최선을 다하고 있으며, 모든 단계에서 함께 하겠습니다. 만약 제품이 기대한 성능을 보이지 않을 경우에도 Product Promise로 보호받으실 수 있습니다.

자세한 내용은 이용 약관을 확인해 주세요.

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-CTNNA2 antibody [EPR1795]

Western blot - Anti-CTNNA2 antibody [EPR1795] (AB76015)

관련 conjugated 항체와 다양한 조성의 항체 (1)

주요 정보

Host species

Clonality

Clone number

Isotype

Carrier free

Reacts with

Applications

Immunogen

보완 제품

Primary Antibodies

Primary Antibodies

Primary Antibodies

Proteins & Peptides

Reactivity 정보

제품 세부 정보

특성 및 보관 정보

제형

Purification 테크닉

보관 버퍼

배송 시 보관 조건

적절한 단기 보관 조건

적절한 장기 보관 조건

분주 정보

보관 정보

추가 정보

Biological function summary

Pathways

제품 프로토콜

타겟 정보

대체 명칭 보기

제품이 사용된 논문 (4)

Product promise